Programming of a Portable Digital Monitoring System-Integrated DNA Aptamer Reversely Regulated Oxidase-Like Nanozyme for Real-Time Dynamic Analysis of Atmospheric Perfluorooctanoic Acid DOI

Chao Nie,

Jiaxu Shui,

Liang Huang

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(33), P. 13512 - 13521

Published: Aug. 7, 2024

Timely and efficient analysis of the fluorinated per- polyfluoroalkyl substances (PFAS) in an atmospheric environment is critical to environmental pollution traceability, early warnings, governance. Here, a portable, reliable, intelligent digital monitoring device for onsite real-time dynamic perfluorooctanoic acid (PFOA) proposed. The sensing mechanism attributed oxidase-like activity PtCoNPs@g-C3N4 that reversely regulated by surface modification PFOA-recognizable DNA aptamer, engineering PFOA-activated nanozyme (Apt-PtCoNPs@g-C3N4) combine nonfluorescence o-phenylenediamine (OPD) as dual-modality response system. present PFOA interacts with its aptamer dissociates from Apt-PtCoNPs@g-C3N4, restoring oxidize OPD into yellow fluorescence 2,3-diphenylaniline (DAP), thereby observing PFOA-triggered colorimetric well change. Then, hydrogel kit-programmed Apt-PtCoNPs@g-C3N4 + system used sensitive element incorporate this homemade portable device, automatically gathering processing image gray values our self-weaving software, ultimately realizing surrounding fluorochemical production plant. This work provides direction theoretical foundation designing screening devices cater other contaminants detection requirements.

Language: Английский

Highly electrostatic cellulose acetate materials assisted by copper ion coordination for air filtration DOI
Ning Yan, Ting Gao, Huayi Li

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159848 - 159848

Published: Jan. 1, 2025

Language: Английский

Citations

2
Per- and poly-fluoroalkyl substances (PFAS) effects on lung health: a perspective on the current literature and future recommendations DOI Creative Commons
Megan E. Solan, Jinah Park

Frontiers in Toxicology, Journal Year: 2024, Volume and Issue: 6

Published: July 18, 2024

Per- and poly-fluoroalkyl substances (PFAS) are a broad class of synthetic compounds widely used in commercial applications. The persistent nature PFAS the environment has earned them epithet “forever chemicals.” Concerns arise from widespread exposure to occupational, household, environmental sources. This use is particularly concerning, as emerging epidemiological evidence highlights their adverse effects on lung health. Such impacts include impaired fetal development, reduced immune function children, potential links cancer. Both vivo vitro studies illuminate mechanisms underlying such health outcomes subsequent inhalation exposure, which may immunomodulation, oxidative stress, disruptions epithelial barriers. However, evidence-based information focusing PFAS-mediated injury lacking. Additionally, discrepancies between data collected animal highlight need for improved approaches better understand toxicity results exposure. To address these gaps, we recommend leveraging route-to-route extrapolation risk assessment, prioritizing research understudied PFAS, adopting physiologically relevant, high-throughput approaches. These strategies aimed at enhancing our understanding effects, aiding more informed management decisions. In this review, summarize current literature emphasizing its health, through inhalation. We then discuss knowledge tissue- cellular-level caused by PFAS.

Language: Английский

Citations

4
Detecting Perfluorooctanoic Acid in Environmental Water Samples by Design of a Novel and Efficient Photoelectrochemical Sensing Platform DOI
Ruoxi He,

Linlin Zhao,

Wenjun Yan

et al.

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Contrapose the frequent occurrence of perfluorooctanoic acid (PFOA) in environment and serious threat to human health, it is urgent establish effective analytical methods for monitoring PFOA levels environment. In this work, a novel efficient PEC sensing platform was developed detection based on CuSe/CdSe/TiO2 nanotube arrays (NTs) composites as photoactive material anti-PFOA aptamer biorecognition element. First, CdSe quantum dots (QDs) with narrow band gap were decorated TiO2 NTs surface. Furthermore, p-n heterojunction structure designed through modifying p-type semiconductor CuSe QDs-decorated NTs. The as-prepared greatly enhanced visible light absorption promoted charge separation, exhibiting good activity. Attributed specific recognition molecules immobilized toward PFOA, formed PFOA-aptamer complexes introduced significant steric hindrance at interface, thereby impeding electron transfer reducing photocurrent density, variation density enabled quantitative determination PFOA. constructed has high sensitivity specificity limit 0.053 pg/L. performance sensor various environmental water samples studied, yielding satisfactory results. Therefore, simple technique been established, providing new solution highly sensitive

Language: Английский

Citations

0
Increased perfluorooctanoic acid accumulation facilitates the migration and invasion of lung cancer cells via remodeling cell mechanics DOI Creative Commons
Jie Mei, Jipeng Jiang,

Zhao Li

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(51)

Published: Dec. 12, 2024

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are widely used in industrial household products, raising serious concerns due to their environmental persistence mobility. Epidemiological studies have reported potential carcinogenic risks of PFAS based on widespread occurrence population exposure. In this study, we observed that perfluorooctanoic acid (PFOA), a common PFAS, functions as mechanical regulator lung cancer cells. PFOA exposure reduces cell stiffness, thereby decreasing adhesion enhancing immune evasion, ultimately exacerbating tumor metastasis. various models, more aggressive metastases been the group. Additionally, serum levels patients with advanced adenocarcinoma were significantly higher than those early-stage disease. Mechanistically, interaction between transmembrane integrins cells triggers changes cellular properties, leading reorganization cytoskeleton, activation intracellular FAK-PI3K-Akt signaling pathway. Our findings demonstrate individuals adenocarcinoma, can increase risk metastasis even at daily levels.

Language: Английский

Citations

2
Programming of a Portable Digital Monitoring System-Integrated DNA Aptamer Reversely Regulated Oxidase-Like Nanozyme for Real-Time Dynamic Analysis of Atmospheric Perfluorooctanoic Acid DOI

Chao Nie,

Jiaxu Shui,

Liang Huang

et al.

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(33), P. 13512 - 13521

Published: Aug. 7, 2024

Timely and efficient analysis of the fluorinated per- polyfluoroalkyl substances (PFAS) in an atmospheric environment is critical to environmental pollution traceability, early warnings, governance. Here, a portable, reliable, intelligent digital monitoring device for onsite real-time dynamic perfluorooctanoic acid (PFOA) proposed. The sensing mechanism attributed oxidase-like activity PtCoNPs@g-C3N4 that reversely regulated by surface modification PFOA-recognizable DNA aptamer, engineering PFOA-activated nanozyme (Apt-PtCoNPs@g-C3N4) combine nonfluorescence o-phenylenediamine (OPD) as dual-modality response system. present PFOA interacts with its aptamer dissociates from Apt-PtCoNPs@g-C3N4, restoring oxidize OPD into yellow fluorescence 2,3-diphenylaniline (DAP), thereby observing PFOA-triggered colorimetric well change. Then, hydrogel kit-programmed Apt-PtCoNPs@g-C3N4 + system used sensitive element incorporate this homemade portable device, automatically gathering processing image gray values our self-weaving software, ultimately realizing surrounding fluorochemical production plant. This work provides direction theoretical foundation designing screening devices cater other contaminants detection requirements.

Language: Английский

Citations

0