CMAP prediction and experimental validation of Forskolin as a podocyte protective and anti-proteinuric drug for nephrotoxic serum-treated mice DOI
Weijun Huang, Peng Yu, Xi Zhao

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 116727 - 116727

Published: Dec. 1, 2024

Language: Английский

Production of non-embryogenic synthetic seeds for short-term cold storage and ISSR marker-assisted genetic fidelity analysis of Coleus forskohlii (Willd) Briq. plants DOI

Mahesh Kumar Badhepuri,

Mahender Aileni,

Prabhakar Rao Beeravelli

et al.

Plant Cell Tissue and Organ Culture (PCTOC), Journal Year: 2025, Volume and Issue: 160(2)

Published: Jan. 31, 2025

Language: Английский

Citations

0
Optimization of Agrobacterium-mediated gene transformation using a non-invasive visual reporter gene (RUBY) in Coleus forskohlii (Willd) Briq. DOI Creative Commons

Mahesh Kumar Badhepuri,

Phanikanth Jogam,

Vaishnavi Anumula

et al.

Discover Plants., Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 17, 2025

Language: Английский

Citations

0
Chemopreventive and Anticancer Activity of Selected Triterpenoids in Melanoma DOI Open Access
Natalia Dycha, Magdalena Michalak, Jacek Jachuła

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(10), P. 1625 - 1625

Published: May 11, 2025

Melanoma is one of the most aggressive forms skin cancer, characterized by high metastatic potential and resistance to conventional therapies. Natural compounds, particularly terpenoids, have gained attention for their chemopreventive anticancer properties. These plant-derived compounds exhibit diverse biological activities, e.g., cell viability proliferation inhibition, apoptosis induction, cycle regulation, immune system modulation. The review evaluates current state art on activity lupane- (betulinic acid), oleanane- (oleanolic acid, β-amyrin, escin, hederagenin, glycyrrhetinic ursane-type (ursolic asiatic madecassic α-amyrin) triterpenoids in melanoma, highlighting mechanisms action, therapeutic potential, challenges clinical application.

Language: Английский

Citations

0
Advances in the Structures, Pharmacological Activities, and Biosynthesis of Plant Diterpenoids DOI
Leilei Li,

Jia Fu,

Nan Liu

et al.

Journal of Microbiology and Biotechnology, Journal Year: 2024, Volume and Issue: 34(8), P. 1563 - 1579

Published: June 17, 2024

Language: Английский

Citations

2
Potential Impacts of Dried Green Coleus forskolin Leaves on Changes of Body and Liver Weight, Glucose and Body Temperature, Serum Profiles in Mice DOI Creative Commons
A.A. Mohammed, S. Al-Suwaiegh, S. Al-Suwaiegh

et al.

Indian Journal of Animal Research, Journal Year: 2024, Volume and Issue: Of

Published: Aug. 22, 2024

Background: Forskolin, an active compound extracted from the Coleus forskohlii plant, has a wide range of potential functions including losses body weight, improves diabetes and cardiovascular health. Methods: Thirty sex albino mice, growing adult males females were classified into two groups; control group (G1) fed basal diet versus C. forskolin containing leaves (G2; 1.5%) for four weeks. Changes liver weight recorded. Rectal temperature glucose values determined. In addition, blood samples collected subjected serum biochemistry analysis. Result: The results indicated that caused significant decrease (P less than 0.05) in addition to increase rectal temperature. parameters (total protein, urea nitrogen, creatinine, aspartate aminotransferase alanine transferases, lactate dehydrogenase) changed due compared diet. It could be concluded 1.5% supplementation modulates thermo-tolerance responses, indices metabolites.

Language: Английский

Citations

0
Coleus forskohlii shows anti-psoriatic activity in imiquimod-induced psoriasis rats DOI Creative Commons
Sagarika Majhi, Iti Chauhan, Deepak Kumar

et al.

Asian Pacific Journal of Tropical Biomedicine, Journal Year: 2024, Volume and Issue: 14(9), P. 382 - 390

Published: Sept. 1, 2024

Objective: To evaluate anti-psoriatic activity of Coleus forskohlii in rats with imiquimod-induced psoriasis. Methods: Imiquimod was used to induce psoriasis rats. Body weight, skin thickness, erythema, scaling, spleen and histological alternations were measured assess the effect . Furthermore, an emulgel formulation containing 10% prepared characterized along its ex vivo permeation studies. Results: The had a pH 5.40±0.36, optimum spreadability (31.67±2.08) g/(cms) viscosity (15 966.67±1 274.10) cps, enhanced both rate extent drug through psoriatic skin. In study, quantity permeated (19.18%), deposited (52.38%), remaining donor compartments (28.31%) satisfactory. significantly alleviated by increasing glutathione superoxide dismutase activity, decreasing malondialdehyde nitric oxide levels, alleviating rat Conclusions: can alleviate psoriasis, which may be as therapeutic candidate for treatment

Language: Английский

Citations

0
High-frequency shoot regeneration, assessment of genetic fidelity, and histochemical analysis of forskolin production in Coleus forskohlii Briq DOI
Monisha Mitra, Anamika Das, Mansour Ghorbanpour

et al.

PROTOPLASMA, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 16, 2024

Language: Английский

Citations

0
CMAP prediction and experimental validation of Forskolin as a podocyte protective and anti-proteinuric drug for nephrotoxic serum-treated mice DOI
Weijun Huang, Peng Yu, Xi Zhao

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 116727 - 116727

Published: Dec. 1, 2024

Language: Английский

Citations

0