Mind your step: social cerebellum in interactive navigation DOI Creative Commons
Meijia Li, Min Pu, Kris Baetens

et al.

Social Cognitive and Affective Neuroscience, Journal Year: 2022, Volume and Issue: 18(1)

Published: July 22, 2022

The posterior cerebellum contributes to dynamic social cognition by building representations and predictions about sequences in which interactions typically take place. However, the extent violations of prior expectations during human interaction activate remains largely unknown. present study examined inconsistent actions, violate desired goal outcomes, using a navigation paradigm protagonist presented gift another agent that was liked or not. As an analogous non-social control condition, pen transported via assembly line filled with ink matched pen's cap Participants (n = 25) were required memorize subsequently reproduce sequence protagonist's trajectory. hypothesized, expectation (vs non-social) sequencing associated activation (Crus 1/2) other cortical mentalizing regions. In contrast, social) recruited cerebellar lobules IV-V, action observation network navigation-related parahippocampal gyrus. There little effect comparison non-sequencing where participants only had observe findings provide further evidence involvement signaling inconsistencies outcomes goal-directed navigation.

Language: Английский

Life Detection From Biological Motion DOI Creative Commons
Nikolaus F. Troje, Dorita H. F. Chang

Current Directions in Psychological Science, Journal Year: 2023, Volume and Issue: 32(1), P. 26 - 32

Published: Feb. 1, 2023

Life motion, the active movements of people and other animals, contains a wealth information that is potentially accessible to visual system an observer. Biological-motion point-light displays have been widely used study both contained in life motion stimuli mechanisms make use it. Biological conveys motion-mediated dynamic shape, which turn can be for identification recognition agent, but it also local invariants humans animals as general detection signals presence agents environment. Here, we review recent research on behavioral, neurophysiological, genetic aspects this life-detection discuss its functional significance light earlier hypotheses.

Language: Английский

Citations

22
Social and emotional learning in the cerebellum DOI
Frank Van Overwalle

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(12), P. 776 - 791

Published: Oct. 21, 2024

Language: Английский

Citations

9
Intermittent Theta Burst Stimulation Over Cerebellum Facilitates Neurological Recovery in Poststroke Depression via the cAMP/PKA/CREB Pathway DOI
Xue Yang, Tao Gui, Shuxian Zhang

et al.

Stroke, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

BACKGROUND: Stroke causes somatic dysfunction and psychological disorders, leading to poststroke depression (PSD). This study investigates mood alterations in PSD models via cerebellar intermittent theta burst stimulation (iTBS). METHODS: animal were developed using middle cerebral artery occlusion chronic unpredictable mild stress procedures. underwent iTBS with different pulse numbers. Neurological recovery was evaluated open-field test, sucrose preference forced swimming balance beam test. Golgi hematoxylin-eosin staining assessed neuronal repair, while quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay (ELISA), immunofluorescence, Western blotting effects on BDNF (brain-derived neurotrophic factor), hypothalamic-pituitary-adrenal axis factors, the cAMP/PKA (protein kinase A)/CREB (cAMP-response element–binding protein) pathway. The first determined of intensities neurological rats. Second, cAMP/PKA/CREB pathway verified adenoviral blockade PKA CREB at iTBS-1800. RESULTS: showed decreased vertical movement, locomotor distance, increased immobility time test score, which reversed by iTBS. dendritic length spine density Purkinje cells, alleviated damage multiple brain regions, enhanced synthesis. It also regulated adrenocorticotropic hormone, cortisol, GR (glucocorticoid receptor) expression, activated CONCLUSIONS: Cerebellar improves activating cAMP-PKA/CREB pathway, increasing BDNF, reducing hyperactivity, suggesting potential for human treatment.

Language: Английский

Citations

1
Non-invasive brain stimulation for patients and healthy subjects: Current challenges and future perspectives DOI Creative Commons
F. Mattioli, Valerio Maglianella,

Sara D'Antonio

et al.

Journal of the Neurological Sciences, Journal Year: 2023, Volume and Issue: 456, P. 122825 - 122825

Published: Dec. 10, 2023

Non-invasive brain stimulation (NIBS) techniques have a rich historical background, yet their utilization has witnessed significant growth only recently. These encompass transcranial electrical and magnetic stimulation, which were initially employed in neuroscience to explore the intricate relationship between behaviour. However, they are increasingly finding application research contexts as means address various neurological, psychiatric, neurodegenerative disorders. This article aims fulfill two primary objectives. Firstly, it seeks showcase current state of art clinical NIBS, highlighting how can improve complement existing treatments. Secondly, provides comprehensive overview NIBS augmenting function healthy individuals, thereby enhancing performance. Furthermore, delves into points convergence divergence these techniques. It also addresses challenges future prospects associated with from ethical standpoints.

Language: Английский

Citations

15
The Involvement of the Posterior Cerebellum in Reconstructing and Predicting Social Action Sequences DOI
Frank Van Overwalle, Min Pu, Qianying Ma

et al.

The Cerebellum, Journal Year: 2021, Volume and Issue: 21(5), P. 733 - 741

Published: Oct. 25, 2021

Language: Английский

Citations

30
The Cerebellum Gets Social: Evidence from an Exploratory Study of Cerebellar, Neurodevelopmental, and Psychiatric Disorders DOI Creative Commons
Giusy Olivito, Libera Siciliano, Silvia Clausi

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 309 - 309

Published: Jan. 22, 2023

Social prediction is a key feature of social cognition (SC), function in which the modulating role cerebellum recognized. Accordingly, cerebellar alterations are reported pathologies, neurodevelopmental disorders, and psychiatric conditions that show SC deficits. Nevertheless, to date, no study has directly compared populations representative these three with respect alterations. Therefore, present exploratory aimed compare profiles individuals neurodegenerative disorders (CB), autism (ASD), bipolar disorder type 2 (BD2), or healthy subjects (HS) using battery tests requiring different degrees processing. The patterns gray matter (GM) were among groups voxel-based morphometry. Compared HS, clinical showed common deficits tasks involving moderate high level prediction. behavioral results consistent presence overlapping GM reduction right Crus II, an area notably involved complex processing Although preliminary, deepen highlight transdiagnostic value functioning pathologies aetiologies, forecasting novel possibilities for shared interventions.

Language: Английский

Citations

13
A meta-analysis of non-invasive brain stimulation (NIBS) effects on cerebellar-associated cognitive processes DOI Creative Commons
Rachele Pezzetta, Filippo Gambarota, Vincenza Tarantino

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 157, P. 105509 - 105509

Published: Dec. 13, 2023

Non-invasive brain stimulation (NIBS) techniques, including transcranial magnetic (TMS) and electrical (tES), have provided valuable insights into the role of cerebellum in cognitive processes. However, replicating findings from studies involving cerebellar poses challenges. This meta-analysis investigates impact NIBS on processes associated with cerebellum. We conducted a systematic search analyzed 66 91 experiments healthy adults who underwent either TMS or direct current (tDCS) targeting The results indicate that anodal tDCS applied to medial enhances performance. In contrast, high-frequency disrupts performance when lateral hemispheres employed online protocols. Similarly, low-frequency continuous theta burst (cTBS) diminish offline Moreover, impairs accuracy. By identifying consistent effects moderators modulation, this contributes improving replicability using provides guidance for future research aimed at developing effective interventions

Language: Английский

Citations

13
Mentalizing and narrative coherence in autistic adults: Cerebellar sequencing and prediction DOI Creative Commons
Tom Bylemans, Elien Heleven, Kris Baetens

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 146, P. 105045 - 105045

Published: Jan. 13, 2023

BYLEMANS, T., et al. Mentalizing and narrative coherence in autistic adults: Cerebellar sequencing prediction. NEUROSCI BIOBEHAV REV, 2022. - This review focuses on adults serves 4 purposes: (1) providing an overview of their difficulties regarding mentalizing (understanding others’ mental states) (structured storytelling), (2) highlighting the relations between both skills by examining behavioral observations shared neural substrates, (3) integrated perspective novel diagnostic tools support services, (4) raising awareness adult autism. We suggest that are related at level level. In addition to traditional network, cerebellum probably as important hub cerebral networks implicated coherence. Future autism research services should tackle new questions within a framework social cerebellar (dys)functioning.

Language: Английский

Citations

12
The Therapeutic Potential of Non-Invasive and Invasive Cerebellar Stimulation Techniques in Hereditary Ataxias DOI Creative Commons
Alberto Benussi, Giorgi Batsikadze, Carina França

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(8), P. 1193 - 1193

Published: April 20, 2023

The degenerative ataxias comprise a heterogeneous group of inherited and acquired disorders that are characterized by progressive cerebellar syndrome, frequently in combination with one or more extracerebellar signs. Specific disease-modifying interventions currently not available for many these rare conditions, which underscores the necessity finding effective symptomatic therapies. During past five to ten years, an increasing number randomized controlled trials have been conducted examining potential different non-invasive brain stimulation techniques induce improvement. In addition, few smaller studies explored deep (DBS) dentate nucleus as invasive means directly modulate output, thereby aiming alleviate ataxia severity. this paper, we comprehensively review clinical neurophysiological effects transcranial direct current (tDCS), repetitive magnetic (rTMS), DBS patients hereditary ataxias, well presumed underlying mechanisms at cellular network level perspectives future research.

Language: Английский

Citations

12
Modulating mental state recognition by anodal tDCS over the cerebellum DOI Creative Commons
Silvia Clausi, Michela Lupo, Giulia Funghi

et al.

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: Dec. 30, 2022

Abstract Increasing evidence from neuroimaging and clinical studies has demonstrated cerebellar involvement in social cognition components, including the mentalizing process. The aim of this study was to apply transcranial direct current stimulation (tDCS) modulate excitability investigate role cerebellum plays mental state recognition. Forty-eight healthy subjects were randomly assigned different groups which anodal, cathodal, or sham tDCS (2 mA for 20 min) delivered centering electrode on vermis stimulate posterior portion cerebellum. ability attribute states others tested before after using a digital version 'Reading Mind Eyes test', includes visual perceptive motor stimuli as control conditions. Correct response reaction times (RTs) recorded. results revealed significant reduction RTs between baseline post-stimulation sessions anodal only (Wilcoxon test p = 0.00055), whereas no effect found cathodal conditions stimuli. Overall, our suggests that might selectively improve recognition constitute an effective strategy positively

Language: Английский

Citations

19