Human Brain Mapping,
Journal Year:
2024,
Volume and Issue:
45(18)
Published: Dec. 15, 2024
The
posterior
cerebellum
and
anterior
basal
ganglia
are
critical
subcortical
structures
for
learning
identifying
dynamic
action
sequences,
in
concert
with
the
neocortex.
present
analysis
investigates
role
of
sequences
during
social
mentalizing,
termed
here
or
sequential
mentalizing.
Although
mentalizing
was
extensively
investigated
last
decade,
were
long
ignored.
We
conducted
an
activation
likelihood
estimation
coordinate-based
meta-analysis
tasks
(with
485
participants
17
studies).
These
required
to
make
inferences
ranging
from
low-level
goals
high-level
beliefs
traits,
while
either
memorizing,
generating
predicting
temporal
actions
involved
(i.e.,
sequencing
condition),
not
non-sequencing
control
did
so
nonsocial
objects
condition).
also
occasionally
included
inconsistencies
behavior.
Results
revealed
that
exhibited
a
preference
social,
sequencing,
inconsistent
information,
showed
inconsistency,
without
general
input.
Meta-analytic
connectivity
further
evidence
coactivation
between
areas
cerebellum,
cerebral
work
underscores
about
sequences.
NeuroImage Clinical,
Journal Year:
2024,
Volume and Issue:
41, P. 103582 - 103582
Published: Jan. 1, 2024
Converging
evidence
points
to
impairments
of
the
predictive
function
exerted
by
cerebellum
as
one
causes
social
cognition
deficits
observed
in
patients
with
cerebellar
disorders.
We
tested
neurorestorative
effects
transcranial
direct
current
stimulation
(ctDCS)
on
use
contextual
expectations
interpret
actions
occurring
ambiguous
sensory
sceneries
a
sample
adolescents
and
young
adults
congenital,
non-progressive
malformation
(CM).
administered
an
action
prediction
task
which,
implicit-learning
phase,
probability
co-occurrence
between
elements
was
manipulated
form
either
strongly
or
moderately
informative
expectations.
Subsequently,
testing
we
probed
these
for
predicting
(i.e.,
temporally
occluded)
actions.
In
sham-controlled,
within-subject
design,
participants
received
anodic
sham
ctDCS
during
task.
Anodic
ctDCS,
compared
sham,
improved
patient's
ability
predict
unfolding
embedded
moderately,
but
not
strongly,
contexts.
These
findings
corroborate
role
using
previously
learned
associations
events
document
efficacy
boost
congenital
malformation.
The
study
encourages
further
exploration
tool
neurorehabilitation
abilities
neurological,
neuropsychiatric,
neurodevelopmental
disorders
featured
macro-
micro-structural
alterations
cerebellum.
Neurological Sciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
Abstract
Objectives
Ataxia
is
a
common
symptom
in
patients
with
Cerebellar
subtype
of
Multiple
system
atrophy
(MSA-C),
but
effective
treatments
remain
elusive.
The
present
study
aims
to
investigate
whether
repetitive
transcranial
magnetic
stimulation
(rTMS)
over
the
bilateral
cerebellum
could
relieve
ataxia
MSA-C.
Patients
and
methods
This
single-center,
randomized
double-blind
trial.
26
MSA-C
were
randomly
divided
into
experimental
group
control
group.
underwent
both
for
10
consecutive
days,
while
was
given
sham
rTMS.
participants
clinical
assessments
at
baseline
(T0),
three
follow-up
timepoints,
that
is,
immediately
after
tenth
treatment
session
(T1),
2
weeks
(T2),
4
(T3)
T1.
Scale
Assessment
Rating
scores
(SARA)
used
as
primary
outcome
measure,
Fatigue
Severity
Scale-9
(FSS-9),
Hamilton
Anxiety
(HAMA)
Depression
Scale-24
(HAMD-24)
secondary
outcomes.
Results
Two-way
repeated
ANOVAs
showed
significant
×
time
interactions
among
SARA
(p
<
0.001),
FSS-9
HAMA
0.001)
HAMD-24
0.001).
Post-hoc
analyses
compared
T0,
activity
improvement
SARA,
T1,
T2
T3,
T1
T2,
no
T3.
Conclusion
rTMS
provide
short-term
improvements
alleviating
symptoms
fatigue,
depression
anxiety,
beneficial
effects
last
more
than
weeks.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 21, 2025
Anxiety
symptoms
occur
more
frequently
during
adolescence
and
early
adulthood,
increasing
the
risk
of
future
anxiety
disorders.
Neuroscientific
research
on
has
primarily
focused
employing
mostly
univariate
approaches,
discounting
large-scale
alterations
brain.
Indeed
adolescents
with
trait
may
display
similar
abnormalities
shown
by
adults
in
brain
regions
ascribed
to
default
mode
network,
associated
self-referential
thinking
rumination-related
processes.
The
present
study
aims
explore
resting-state
connectivity
patterns
a
large
sample
young
individuals.
We
analyzed
rs-fMRI
images
1263
(mean
age
20.55
years)
their
scores
trait.
A
significant
association
between
functional
two
networks
was
found,
some
overlapping
such
as
cingulate
gyrus,
middle
temporal
gyri
precuneus.
Of
note,
higher
anxiety,
lower
within
both
networks,
suggesting
abnormal
processing,
awareness,
emotion
regulation
abilities
high
These
findings
provided
better
understanding
rs-functional
connectivity,
pave
way
for
development
potential
biomarkers
anxiety.
The Cerebellum,
Journal Year:
2025,
Volume and Issue:
24(4)
Published: April 26, 2025
Cerebellar
dysfunction
affects
socio-affective
abilities
beyond
motor
control.
Recent
studies
suggest
that
non-invasive
cerebellar
neurostimulation
can
modulate
social
cognition
networks,
offering
potential
therapeutic
benefits
for
children
with
autism,
ADHD,
and
mood
disorders.
However,
its
application
in
pediatrics
remains
largely
unexplored.
This
review
summarizes
emerging
pediatric
research
on
transcranial
magnetic
stimulation
(TMS)
direct
current
(tDCS).
We
discuss
their
mechanisms,
benefits,
safety
considerations,
highlighting
preliminary
findings
feasibility
effectiveness.
Ethical
concerns
technical
challenges
related
to
neuroanatomy
parameters
are
also
addressed.
While
early
results
promising,
further
clinical
trials
neurophysiological
essential
optimize
protocols
confirm
long-term
efficacy.
Advancing
our
understanding
of
involvement
functions
could
lead
innovative
rehabilitation
strategies
neurodevelopmental
Neuroscience & Biobehavioral Reviews,
Journal Year:
2025,
Volume and Issue:
174, P. 106194 - 106194
Published: May 3, 2025
Though
cortical
changes
in
frontotemporal
dementia
(FTD)
are
well-documented,
the
cerebellum's
role,
closely
linked
to
these
areas,
remains
unclear.
To
provide
evidence
on
cerebellar
involvement
FTD
across
clinical,
genetic,
imaging,
neuropathological,
and
neurophysiological
perspectives.
Additionally,
we
sought
supporting
application
of
non-invasive
brain
stimulation
(NIBS)
for
both
diagnostic
therapeutic
purposes.
We
performed
a
literature
review
using
MEDLINE
(via
PubMed),
Scopus,
Web
Science
databases.
emphasized
specific
regions
which
differentiate
each
subtypes
may
account
some
characteristic
symptoms.
Furthermore,
highlighted
peculiarities
genetic
alterations.
Finally,
outlined
role
cerebellum
pathogenesis.
The
is
critically
involved
spectrum.
Moreover,
it
can
be
speculated
that
modulation,
as
already
shown
other
neurodegenerative
disorders,
could
restore
interneuronal
intracortical
circuits
typically
impaired
patients,
providing
clinical
improvements
fundamental
outcome
measures
trials.
