Micro(nano)plastics: invisible compounds with a visible impact DOI Creative Commons
Prabhakar Sharma, Prateek Sharma

F1000Research, Journal Year: 2024, Volume and Issue: 13, P. 69 - 69

Published: Jan. 15, 2024

The plastic related research has been an epicentre in recent times. The presence and spread of micro (nano) plastics (MNPs) are well-known the terrestrial aquatic environment. However, focus on fate remediation MNP soil groundwater is limited. bioaccumulation ingested MNPs remain unknown within digestive tract animals. There also a significant knowledge gap understanding ubiquitous organic environmental pollutants with biological systems. Reducing consumption, improving waste management practices, developing environmentally friendly alternatives some key steps needed to address pollution. For better handling protect environment from these invisible substances, policymakers researchers urgently need monitor map contamination groundwater.

Language: Английский

Biotechnological methods to remove microplastics: a review DOI Open Access

Uttpal Anand,

Satarupa Dey, Elza Bontempi

et al.

Environmental Chemistry Letters, Journal Year: 2023, Volume and Issue: 21(3), P. 1787 - 1810

Published: Feb. 8, 2023

Language: Английский

Citations

144
Micro- and Nanoplastics Breach the Blood–Brain Barrier (BBB): Biomolecular Corona’s Role Revealed DOI Creative Commons
Verena Kopatz, Kevin Wen,

Tibor Kovács

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(8), P. 1404 - 1404

Published: April 19, 2023

Humans are continuously exposed to polymeric materials such as in textiles, car tires and packaging. Unfortunately, their break down products pollute our environment, leading widespread contamination with micro- nanoplastics (MNPs). The blood–brain barrier (BBB) is an important biological that protects the brain from harmful substances. In study we performed short term uptake studies mice orally administered polystyrene micro-/nanoparticles (9.55 µm, 1.14 0.293 µm). We show nanometer sized particles—but not bigger particles—reach within only 2 h after gavage. To understand transport mechanism, coarse-grained molecular dynamics simulations on interaction of DOPC bilayers a nanoparticle presence absence various coronae. found composition biomolecular corona surrounding plastic particles was critical for passage through BBB. Cholesterol molecules enhanced these contaminants into membrane BBB, whereas protein model inhibited it. These opposing effects could explain passive brain.

Language: Английский

Citations

140
Nanoplastic occurrence, transformation and toxicity: a review DOI

Thilakshani Atugoda,

Hansika Piyumali,

Hasintha Wijesekara

et al.

Environmental Chemistry Letters, Journal Year: 2022, Volume and Issue: 21(1), P. 363 - 381

Published: Aug. 28, 2022

Language: Английский

Citations

94
Gross Negligence: Impacts of Microplastics and Plastic Leachates on Phytoplankton Community and Ecosystem Dynamics DOI

C. Amaneesh,

Shankari Anna Balan,

P. Silpa

et al.

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 57(1), P. 5 - 24

Published: Dec. 19, 2022

Plastic debris is an established environmental menace affecting aquatic systems globally. Recently, microplastics (MP) and plastic leachates (PL) have been detected in vital human organs, the vascular system, vitro animal studies positing severe health hazards. MP PL found every conceivable ecosystem─from open oceans deep sea floors to supposedly pristine glacier lakes snow covered mountain catchment sites. Many documented impacts on a variety of organisms, whereby some exclusively focus microorganisms. Yet, specific primary producers not systematically analyzed. Therefore, this review focuses threats posed by MP, PL, associated chemicals phytoplankton, their comprehensive at organismal, community, ecosystem scales, endogenous amelioration. Studies MP- PL-impacted individual phytoplankton species reveal production reactive oxygen species, lipid peroxidation, physical damage thylakoids, other physiological metabolic changes, followed homo- heteroaggregations, ultimately eventuating decreased photosynthesis productivity. Likewise, analyses microbial community plastisphere show radically different profile compared surrounding planktonic diversity. The also enriches multidrug-resistant bacteria, cyanotoxins, pollutants, accelerating succession, changing microbiome, thus, diversity evolution. These cellular scales manifest changed dynamics with widespread bottom-up top-down effects biodiversity food web interactions. adverse effects─through altered nutrient cycling─have "knock-on" biogeochemical cycles greenhouse gases. Consequently, these affect provisioning regulating services. Our citation network (CNA) further demonstrate dire all trophic levels, thereby unsettling stability CNA points several emerging nodes indicating combined toxicity hazards phytoplankton. Taken together, our study shows that ecotoxicity particles placed ecosystems peril.

Language: Английский

Citations

73
Neurotoxicity and endocrine disruption caused by polystyrene nanoparticles in zebrafish embryo DOI Creative Commons
Mónica Torres-Ruíz, Mercedes de Alba González, Mònica Morales

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 874, P. 162406 - 162406

Published: Feb. 23, 2023

Nanoplastics (NP) are present in aquatic and terrestrial ecosystems. Humans can be exposed to them through contaminated water, food, air, or personal care products. Mechanisms of NP toxicity largely unknown the Zebrafish embryo poses an ideal model investigate due its high homology with humans. Our objective study was combine a battery behavioral assays endocrine related gene expression, further explore potential neurotoxic effects on animal behavior. Polystyrene nanoplastics (PSNP) were used evaluate toxicity. neurobehavioral profiles include tail coiling assay, light/dark activity two thigmotaxis anxiety (auditory visual stimuli), startle response - habituation assay auditory stimuli. Results show PSNP accumulated eyes, neuromasts, brain, digestive system organs. inhibited acetylcholinesterase altered endocrine-related expression both thyroid glucocorticoid axes. At whole organism level, we observed behaviors such as increased at lower doses lethargy higher dose, which could variety complex mechanisms ranging from sensory organ central nervous others hormonal imbalances. In addition, hypothetical adverse outcome pathway these effects. conclusion, this provides new understanding into toxic zebrafish embryo, emphasizing critical role disruption effects, improving our their health risks human populations.

Language: Английский

Citations

50
Circularity in polymers: addressing performance and sustainability challenges using dynamic covalent chemistries DOI Creative Commons
Tianwei Yan, Alex H. Balzer, Katie M. Herbert

et al.

Chemical Science, Journal Year: 2023, Volume and Issue: 14(20), P. 5243 - 5265

Published: Jan. 1, 2023

This review provides a multidisciplinary overview of the challenges and opportunities for dynamic covalent chemistry-based macromolecules towards design new, sustainable, recyclable materials circular economy.

Language: Английский

Citations

46
Microplastics role in cell migration and distribution during cancer cell division DOI Creative Commons

Ekaterina Brynzak-Schreiber,

Elisabeth Schögl,

Carolin Bapp

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 353, P. 141463 - 141463

Published: Feb. 27, 2024

Amidst the global plastic pollution crisis, gastrointestinal tract serves as primary entry point for daily exposure to micro- and nanoplastics. We investigated complex dynamics between polystyrene nanoplastics (PS-MNPs) four distinct human colorectal cancer cell lines (HT29, HCT116, SW480, SW620). Our findings revealed a significant size- concentration dependent uptake of 0.25, 1, 10 μm PS-MNPs across all lines, with HCT116 cells exhibiting highest rates. During division, particles were distributed mother daughter cells. Interestingly, we observed no signs elimination from Short-term 0.25 significantly amplified migration, potentially leading pro-metastatic effects. Particles demonstrated high persistence in 2D 3D cultures, accumulation non-proliferating parts spheroids, without interfering proliferation or division. study unveils disturbing fact bioaccumulation MNPs key toxicological traits under REACH (Regulation concerning Registration, Evaluation, Authorisation Restriction Chemicals). observations underscore potential hidden catalysts tumor progression, particularly through enhancing migration possibly fueling metastasis - finding that sheds light on previously underexplored area concern.

Language: Английский

Citations

38
A just world on a safe planet: a Lancet Planetary Health–Earth Commission report on Earth-system boundaries, translations, and transformations DOI Creative Commons
Joyeeta Gupta, Xuemei Bai, Diana Liverman

et al.

The Lancet Planetary Health, Journal Year: 2024, Volume and Issue: 8(10), P. e813 - e873

Published: Sept. 12, 2024

Language: Английский

Citations

35
Impact of nanoplastics on Alzheimer ’s disease: Enhanced amyloid-β peptide aggregation and augmented neurotoxicity DOI

Xiaoli Gou,

Yongchun Fu,

Juan Li

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 465, P. 133518 - 133518

Published: Jan. 13, 2024

Language: Английский

Citations

21
Ingested microplastics: Do humans eat one credit card per week? DOI Creative Commons
Martin Pletz

Journal of Hazardous Materials Letters, Journal Year: 2022, Volume and Issue: 3, P. 100071 - 100071

Published: Nov. 1, 2022

Ingested Microplastic (MP) particles can harm the human body. Estimations of total mass ingested MP correspond to 50 plastic bags per year (Bai et al., 2022), one credit card week (Gruber or a median value 4.1▒μg/week for adults (Mohamed Nor 2021). The first two estimations are based on an analysis (Senathirajah 2021) that predicts mi,MP 0.1–5▒g/week. This work revisits and evaluates this calculation compares its results methods Mohamed al. (2021). Senathirajah combines data averaged particle masses m¯MP from papers reported sizes counts nMP in shellfish, salt, beer, water other detected particles. Combined with estimated weekly consumption those consumables, they compute mi,MP. raises some serious issues way combine obtained sizes. It concludes overestimates by several orders magnitude be considered as rather irrelevant factor toxic effects

Language: Английский

Citations

57