Diethyl nitrosamine-induces neurobehavioral deficit, oxido-nitrosative stress in rats' brain: a neuroprotective role of diphenyl diselenide DOI Creative Commons
Solomon E. Owumi, Joseph Chimezie,

Praise Dyap Emmanuel

et al.

BMC Neuroscience, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 25, 2024

Diethylnitrosamine (DEN), a common dietary carcinogen, is associated with neurotoxicity in humans and animals. This study investigated the neuroprotective effects of diphenyl diselenide (DPDS) against DEN-induced male Albino Wistar rats (n = 40). Rats were randomly distributed into cohorts treated as follows: vehicle control (corn oil 2 mL/kg; gavage), DPDS-only (5 mg/kg; gavage) DEN-only (200 single dose i.p.). Also, two other rat pre-treated DPDS (3 or 5 mg/kg) for 15 days (day: 0–15), subsequently administered DEN continuously another 7 days, (days:15–21). Behavioural tests (OFT- using open field test; NORT- novel object recognition FST- forced swimming test Y-maze) conducted from 19–21, followed by biochemical analysis hippocampus prefrontal cortex oxidative stress, inflammation, neurotransmitter metabolic enzyme, histopathology. DEN-treated exhibited decreased locomotor activity, spatial memory function antioxidant increased nitration anxiety, depressive-like behaviour, causing histoarchitectural damage hippocampal cortices. treatment (pre- post-DEN exposure) significantly alleviated these neurotoxic, oxidative, effects, reversed histopathological alterations, improved locomotive cognitive functions. In conclusion, demonstrates potent toxicity, likely through enhanced endogenous capacity that mitigates oxido-nitrative damage. These findings suggest organo-selenium -DPDS- promising chemotherapeutic agent alleviating DEN-mediated maintaining brain health.

Language: Английский

Neurotoxic mechanisms of mycotoxins: Focus on aflatoxin B1 and T-2 toxin DOI
Chao Song, Zixu Wang, Jing Cao

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 356, P. 124359 - 124359

Published: June 12, 2024

Language: Английский

Citations

14
Hesperetin alleviates aflatoxin B1 induced liver toxicity in mice: Modulating lipid peroxidation and ferritin autophagy DOI Creative Commons
Chao Song, Zixu Wang,

Jing Cao

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116854 - 116854

Published: Aug. 13, 2024

One of the ways Aflatoxin B1 damages liver is through ferroptosis. Ferroptosis characterized by build-up lipid peroxides and reactive oxygen species (ROS) due to an excess iron. Dietary supplements have emerged as a promising strategy for treating ferroptosis in liver. The flavonoid component hesperetin, which mostly present citrus fruits, has number pharmacological actions, such those against fibrosis, cancer, hyperglycemia. However, hesperetin's effects mechanisms hepatic are still unknown. In this study, 24 male C57BL/6 J mice were randomly assigned CON, AFB1 (0.45 mg/kg/day), AFB1+ hesperetin treatment groups (40 mg/kg/day). results showed that improved structural damage mouse liver, down-regulated inflammatory factors (Cxcl1, Cxcl2, CD80, F4/80), alleviated fibrosis induced aflatoxin B1. Hesperetin reduced peroxidation iron accumulation up-regulating levels antioxidant enzymes (GPX4, GSH-Px, CAT, T-AOC). It worth noting not only but also maintained dynamic balance ions reducing ferritin autophagy. Mechanistically, ability regulate autophagy depends on PI3K/AKT/mTOR/ULK1 pathway. AFB1-induced HepG2 cells, addition PI3K inhibitor (LY294002) AKT (Miransertib) confirmed regulated pathway inhibit degradation lysosomes. summary, our suggest regulates system inhibits hyperautophagy, thereby mitigate peroxidation. This work provides fresh perspective mechanism behind mice.

Language: Английский

Citations

8
Cellular and molecular mechanisms of aflatoxin B1-mediated neurotoxicity: The therapeutic role of natural bioactive compounds DOI
Isaac A. Adedara, Oluwadarasimi E. Atanda, Camila Sant’Anna Monteiro

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 237, P. 116869 - 116869

Published: Aug. 9, 2023

Language: Английский

Citations

13
Curcumin alleviates AFB1-induced nephrotoxicity in ducks: regulating mitochondrial oxidative stress, ferritinophagy, and ferroptosis DOI
Haiyan Liu, Ying He,

Xinglin Gao

et al.

Mycotoxin Research, Journal Year: 2023, Volume and Issue: 39(4), P. 437 - 451

Published: Oct. 2, 2023

Language: Английский

Citations

12
Antifungal properties of cathelicidin LL-37: current knowledge and future research directions DOI
Mojtaba Memariani, Hamed Memariani

World Journal of Microbiology and Biotechnology, Journal Year: 2023, Volume and Issue: 40(1)

Published: Dec. 7, 2023

Language: Английский

Citations

12
Lutein and Zeaxanthin abated neurobehavioral, neurochemical and oxido-inflammatory derangement in rats intoxicated with aflatoxin B1. DOI
Solomon E. Owumi, Joseph Chimezie, Maryam Salami

et al.

Toxicon, Journal Year: 2025, Volume and Issue: unknown, P. 108345 - 108345

Published: April 1, 2025

Language: Английский

Citations

0
Dietary aflatoxin B1 and antimalarial—a lumefantrine/artesunate—therapy perturbs male rat reproductive function via pro-inflammatory and oxidative mechanisms DOI Creative Commons
Solomon E. Owumi,

Angel O. Umez,

Uche O. Arunsi

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: July 27, 2023

Abstract We investigated the impact of Coartem™ (COA) and aflatoxin B1 (AFB 1 ) on rats’ hypothalamus, epididymis, testis. Male rats were randomly grouped (n = 5 rats) treated: control group (corn oil), AFB (70 µg/kg), COA (5 mg/kg), + 0.035 mg/kg) 0.07 for 28 days. Blood samples collected serum prolactin, testosterone, follicle-stimulating luteinising hormones (FSH LH) assay upon sacrifice. The semen, testes harvested morphological, biochemical, histopathology determination oxidative, inflammation stress, genomic integrity, pathological alterations. Exposure to caused cauda epididymal spermatozoa display low motility, viability, volume, with increased abnormalities. Hormonal disruption ensued in animals exposed alone or together, exemplified by decreased FSH LH levels. Treatment-related reduction biomarkers testicular metabolism—acid alkaline phosphatases, glucose-6-phosphate dehydrogenase, lactate dehydrogenase—were observed. Also, treatment reductions antioxidant (Glutathione total thiols) levels enzyme (Catalase, superoxide dismutase, glutathione peroxidase, glutathione-S-transferase) activities examined organs. At same time, treatment-related increases DNA damage (p53), oxidative stress (xanthine oxidase, reactive oxygen nitrogen species lipid peroxidation), (nitric oxide tumour necrosis factor-alpha), apoptosis (caspase-9, -3) Chronic exposure AFB1 led inflammation, male rats' hypothalamic-reproductive axis, which might potentiate infertility if not contained.

Language: Английский

Citations

8
Epirubicin Treatment Induces Neurobehavioral, Oxido-Inflammatory and Neurohistology Alterations in Rats: Protective Effect of the Endogenous Metabolite of Tryptophan − 3-Indolepropionic Acid DOI
Solomon E. Owumi,

Grace Adebisi

Neurochemical Research, Journal Year: 2023, Volume and Issue: 48(9), P. 2767 - 2783

Published: April 25, 2023

Language: Английский

Citations

4
Eco-friendly synthesis and assessment of chrysin – primed zinc ferrite nanoparticles against vinyl chloride and 2-acetylaminofluorene model of hepatorenal injury in rats DOI Creative Commons

Adedotun F. Adesina,

Adewale Adewuyi, Chiagoziem A. Otuechere

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 7, P. 101524 - 101524

Published: Jan. 1, 2024

Language: Английский

Citations

1
Diethyl nitrosamine-induces neurobehavioral deficit, oxido-nitrosative stress in rats' brain: a neuroprotective role of diphenyl diselenide DOI Creative Commons
Solomon E. Owumi, Joseph Chimezie,

Praise Dyap Emmanuel

et al.

BMC Neuroscience, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 25, 2024

Diethylnitrosamine (DEN), a common dietary carcinogen, is associated with neurotoxicity in humans and animals. This study investigated the neuroprotective effects of diphenyl diselenide (DPDS) against DEN-induced male Albino Wistar rats (n = 40). Rats were randomly distributed into cohorts treated as follows: vehicle control (corn oil 2 mL/kg; gavage), DPDS-only (5 mg/kg; gavage) DEN-only (200 single dose i.p.). Also, two other rat pre-treated DPDS (3 or 5 mg/kg) for 15 days (day: 0–15), subsequently administered DEN continuously another 7 days, (days:15–21). Behavioural tests (OFT- using open field test; NORT- novel object recognition FST- forced swimming test Y-maze) conducted from 19–21, followed by biochemical analysis hippocampus prefrontal cortex oxidative stress, inflammation, neurotransmitter metabolic enzyme, histopathology. DEN-treated exhibited decreased locomotor activity, spatial memory function antioxidant increased nitration anxiety, depressive-like behaviour, causing histoarchitectural damage hippocampal cortices. treatment (pre- post-DEN exposure) significantly alleviated these neurotoxic, oxidative, effects, reversed histopathological alterations, improved locomotive cognitive functions. In conclusion, demonstrates potent toxicity, likely through enhanced endogenous capacity that mitigates oxido-nitrative damage. These findings suggest organo-selenium -DPDS- promising chemotherapeutic agent alleviating DEN-mediated maintaining brain health.

Language: Английский

Citations

1