Сенсорные системы, Journal Year: 2023, Volume and Issue: 37(3), P. 205 - 217
Published: July 1, 2023
Language: Английский
Investigative Ophthalmology & Visual Science, Journal Year: 2024, Volume and Issue: 65(12), P. 20 - 20
Published: Oct. 15, 2024
Age-related macular degeneration (AMD) stands as a leading cause of severe visual impairment and blindness among the elderly globally. As multifactorial disease, AMD's pathogenesis is influenced by genetic, environmental, age-related factors, with lipid metabolism abnormalities complement system dysregulation playing critical roles. This review delves into recent advancements in understanding intricate interaction between these two crucial pathways, highlighting their contribution to disease's progression through chronic inflammation, drusen formation, retinal pigment epithelium dysfunction. Importantly, emerging evidence points dysregulated profiles, particularly alterations high-density lipoprotein levels, oxidized deposits, intracellular lipofuscin accumulation, exacerbating factors that enhance activation subsequently amplify tissue damage AMD. Furthermore, genetic studies have revealed significant associations AMD specific genes involved transport regulation, shedding light on disease susceptibility underlying mechanisms. The further explores clinical implications findings, advocating for novel therapeutic approach integrates modulators inhibitors. By concurrently targeting dual-targeted holds promise significantly improving outcomes patients, heralding new horizon management treatment.
Language: Английский
Citations
4
Experimental Eye Research, Journal Year: 2025, Volume and Issue: 252, P. 110270 - 110270
Published: Feb. 7, 2025
Language: Английский
Citations
0
Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown, P. 259 - 263
Published: Jan. 1, 2025
Language: Английский
Citations
0
Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 215 - 215
Published: Feb. 13, 2025
Ferroptosis, an iron-dependent form of non-apoptotic cell death, is regulated by a complex network involving lipid metabolism, iron homeostasis, and the oxidative-reductive system, with accumulation peroxidation as key drivers. Mitochondrial dysfunction ROS overproduction often underlie pathogenesis mitochondrial diseases, for which treatment options are limited, emphasizing need novel therapies. In this study, we investigated whether polydatin nicotinamide could reverse ferroptosis-related pathological features in cellular models derived from patients pathogenic GFM1 variants. Mutant fibroblasts showed increased lipofuscin accumulation, altered expression metabolism-related proteins, elevated peroxidation, heightened susceptibility to erastin-induced ferroptosis. Treatment effectively corrected these alterations reduced induced neurons. Furthermore, chloramphenicol control cells mimicked mutant phenotype, suggesting that changes linked protein synthesis defect characteristic Notably, adding vitamin E co-treatment resulted reduction minimum effective concentration, potential benefits its inclusion. conclusion, combination polydatin, nicotinamide, represent promising therapeutic option disorders caused
Language: Английский
Citations
0
Survey of Ophthalmology, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Diagnostics, Journal Year: 2024, Volume and Issue: 14(7), P. 764 - 764
Published: April 3, 2024
The imagistic evaluation of non-neovascular age-related macular degeneration (AMD) is crucial for diagnosis, monitoring progression, and guiding management the disease. Dry AMD, characterized primarily by presence drusen retinal pigment epithelium atrophy, requires detailed visualization structure to assess its severity progression. Several imaging modalities are pivotal in including optical coherence tomography, fundus autofluorescence, or color photography. In context emerging therapies geographic like pegcetacoplan, it critical establish baseline status disease, monitor development expansion evaluate retina’s response potential treatments clinical trials. present review, while initially providing a comprehensive description pathophysiology involved aims offer an overview employed AMD. Special emphasis placed on assessment progression biomarkers as discerned through tomography. As landscape AMD treatment continues evolve, advanced techniques will remain at forefront, enabling clinicians most effective tailored their patients.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13099 - 13099
Published: Aug. 23, 2023
It is known that during the process of aging, there a significant decrease in number melanosomes retinal pigment epithelium (RPE) cells human eye. Melanosomes act as screening pigments RPE and are fundamentally important for protection against free radicals generated by light. A loss or change quality melanin can lead to development senile pathologies aggravation various diseases. We have previously shown interaction between superoxide results oxidative degradation with formation water-soluble fluorescent products. In present study, we show, using fluorescence analysis, HPLC, mass spectrometry, visible light irradiation on melanolipofuscin granules isolated from eye products melanin, which was contrast lipofuscin irradiation. The these occurs result radicals, part granule. identified both composition irradiated were not but were, instead, oxidized radicals. light, ions could be associated applying principal component analysis time-of-flight secondary ion spectrometry (ToF-SIMS) data. Degradation intact also possible; however, this requires significantly higher intensities than granules. concluded concentration age due its reactive oxygen species lipofuscin, granules, under action
Language: Английский
Citations
7
Биофизика, Journal Year: 2024, Volume and Issue: 69(2), P. 257 - 263
Published: June 21, 2024
Language: Английский
Citations
1
Experimental Eye Research, Journal Year: 2024, Volume and Issue: 249, P. 110142 - 110142
Published: Oct. 28, 2024
Language: Английский
Citations
1
FEBS Journal, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 24, 2024
Photodamage to the outer segments of photoreceptor cells and their impaired utilization by retinal pigment epithelium (RPE) contribute development age‐related macular degeneration (AMD) leading blindness. Degeneration RPE is triggered reactive oxygen species (ROS) produced photochemical reactions involving bisretinoids, by‐products visual cycle, which accumulate in discs lipofuscin granules RPE. Carotenoids, natural antioxidants with high potential efficacy against a wide range ROS, may protect cytotoxic properties lipofuscin. To solve problem hydrophobicity carotenoids increase bioaccessibility, specialized proteins can ensure targeted delivery affected tissues. In this study, we present new capabilities recombinant water‐soluble protein AstaP from Coelastrella astaxanthina Ki‐4 (Scenedesmaceae) for protein‐mediated carotenoid demonstrate how zeaxanthin suppresses oxidative stress lipofuscin‐enriched model cells. complex effectively scavenge various ROS (singlet oxygen, free radical cations, hydrogen peroxide) previously reported be generated AMD. addition, explore optimizing structure enhance its thermal stability resistance proteolytic activity ocular media. This optimization aims maximize prevention degenerative changes
Language: Английский
Citations
1