Photoprotective Effects of Phytochemicals on Blue Light-Induced Retinal Damage: Current Evidence and Future Perspectives

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 331 - 331

Published: Jan. 17, 2025

The widespread use of light-emitting diodes (LEDs) has increased blue light (BL) exposure, raising concerns about its potential adverse effects on ocular health. Prolonged exposure to BL been implicated in the pathogenesis various retinal disorders, including age-related macular degeneration (AMD), primarily through mechanisms involving oxidative stress and inflammation mediated by overproduction reactive oxygen species (ROS). This review synthesizes current evidence photoprotective properties dietary bioactive compounds, (e.g., anthocyanins, curcumin, quercetin, myricetin, resveratrol), with a focus their mitigate BL-induced damage. Accumulating research suggests that antioxidants, particularly polyphenols, may offer benefits. These phytochemicals act neutralizing ROS enhancing retina's endogenous antioxidant capacity. Based these findings, this advocates for food-first approach future investigations, emphasizing development evidence-based recommendations bolster health risk BL-related diseases. Considering lack empirical clinical studies examining impact human health, field hazard should prioritize two key approaches: conducting large-scale epidemiological surveys implementing trials functional ingredients have demonstrated beneficial against photodamage preclinical animal studies.

Language: Английский

Beneficial Effect of Rebamipide Eye Drops on Blue Light-Induced Oxidative Damage in the Ocular Surface

Journal of Ocular Pharmacology and Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Purpose: We evaluated the capacity of rebamipide (REB) to alleviate corneal epithelial damage induced via blue light (BL) exposure. Methods: Eight-week-old C57BL/6 mice were exposed BL (410 nm, 100 J) twice daily for 10 days. The randomly divided into 5 groups: 1 untreated and 4 groups receiving exposure ± different topical treatments: alone, carboxymethylcellulose, 5% N-acetylcysteine, REB. Reactive oxygen species (ROS) levels assessed, Bcl-2-associated X protein (BAX) was analyzed. Apoptotic cells detected, inflammatory cytokine [tumor necrosis factor-alpha (TNF-α) interleukin-6 (IL-6)] measured using enzyme-linked immunosorbent assay (ELISA), histopathological changes in cornea hematoxylin eosin (H&E) staining. Results: REB group demonstrated significantly lower exposure-induced ROS (P < 0.01) BAX expression than group. number Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) positive 0.01). Furthermore, ELISA analysis revealed reduced TNF-α IL-6 relative Hematoxylin staining showed preservation thickness. Conclusions: Rebamipide alleviated BL-induced oxidative ocular surfaces by reducing levels, inhibiting apoptosis, suppressing expression.

Language: Английский