Gels,
Journal Year:
2024,
Volume and Issue:
10(11), P. 693 - 693
Published: Oct. 25, 2024
Hydrogels
are
known
for
their
high
water
retention
capacity
and
biocompatibility
have
become
essential
materials
in
tissue
engineering
drug
delivery
systems.
This
review
explores
recent
advancements
hydrogel
technology,
focusing
on
innovative
types
such
as
self-healing,
tough,
smart,
hybrid
hydrogels,
each
engineered
to
overcome
the
limitations
of
conventional
hydrogels.
Self-healing
hydrogels
can
autonomously
repair
structural
damage,
making
them
well-suited
applications
dynamic
biomedical
environments.
Tough
designed
with
enhanced
mechanical
properties,
enabling
use
load-bearing
cartilage
regeneration.
Smart
respond
external
stimuli,
including
changes
pH,
temperature,
electromagnetic
fields,
ideal
controlled
release
tailored
specific
medical
needs.
Hybrid
made
from
both
natural
synthetic
polymers,
combine
bioactivity
resilience,
which
is
particularly
valuable
complex
tissues.
Despite
these
innovations,
challenges
optimizing
biocompatibility,
adjusting
degradation
rates,
scaling
up
production
remain.
provides
an
in-depth
analysis
emerging
technologies,
highlighting
transformative
potential
while
outlining
future
directions
development
applications.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(19), P. 14757 - 14757
Published: Sept. 29, 2023
In
recent
years,
Solution
Blow
Spinning
(SBS)
has
emerged
as
a
new
technology
for
the
production
of
polymeric,
nanocomposite,
and
ceramic
materials
in
form
nano
microfibers,
with
similar
features
to
those
achieved
by
other
procedures.
The
advantages
SBS
over
spinning
methods
are
fast
generation
fibers
simplicity
experimental
setup
that
opens
up
possibility
their
on-site
production.
While
producing
large
number
nanofibers
short
time
is
crucial
factor
large-scale
manufacturing,
situ
generation,
example,
sprayable,
multifunctional
dressings,
capable
releasing
embedded
active
agents
on
wounded
tissue,
or
use
operating
rooms
prevent
hemostasis
during
surgical
interventions,
open
wide
range
possibilities.
interest
this
evident
from
growing
patents
issued
articles
published
last
few
years.
Our
focus
review
biomedicine-oriented
applications
based
collection
most
relevant
scientific
papers
date.
Drug
delivery,
3D
culturing,
regenerative
medicine,
fabrication
biosensors
some
areas
which
been
explored,
frequently
at
proof-of-concept
level.
promising
results
obtained
demonstrate
potential
biomedical
pharmaceutical
fields.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(11), P. 13071 - 13088
Published: May 23, 2024
Peri-implantitis
is
an
excessive
inflammatory
response
induced
by
complex
interactions
between
the
bacteria,
host
immune
system,
and
tissues
around
dental
implant.
Alveolar
bone
resorption
caused
peri-implantitis
a
significant
cause
of
implant
failure.
However,
to
restore
osteogenic
microenvironment,
multifaceted
therapeutic
method
that
simultaneously
encompasses
anti-inflammatory
tissue
regenerative
strategies
indispensable.
In
this
study,
temperature-sensitive
hydrogel
(FMXO)
loaded
with
MXene
MgO
was
used
develop
multifunctional
injectable
MXene-based
hydrogel.
This
could
release
in
irregular
defect
areas
situ
no
toxicity,
either
vitro
or
vivo.
Our
results
showed
FMXO
effectively
inhibited
NF-κB
signaling
pathway
RAW264.7
cells
upregulated
expression
ALP,
Runx2,
OCN
marrow
mesenchymal
stromal
(BMSCs).
Therefore,
exerted
pharmacological
effects
on
inflammation
regeneration.
Moreover,
we
found
FMXO,
when
exposed
near-infrared
(NIR)
light,
exhibited
high
efficacy
against
Porphyromonas
gingivalis,
Fusobacterium
nucleatum,
their
plaque
microorganisms,
which
were
considered
initiating
factors
peri-implantitis.
The
multifunctionality
also
confirmed
immediate
peri-implant
rat
model
vivo,
suggesting
great
potential
for
therapy
clinic.
Engineering,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 1, 2024
Bone
injuries
induced
by
accidents
or
bone-related
disease
have
dramatically
increased
in
the
past
decades.
The
application
of
biomaterials
has
become
an
inextricable
part
treatment
for
new
bone
formation
and
regeneration.
Different
from
traditional
bone-regeneration
materials,
injectable
biomaterials-ranging
bioceramics
to
polymers-have
been
applied
as
a
means
promoting
surgery
with
minimal
intervention
approach.
In
this
review,
we
summarize
most
recent
developments
minimally
invasive
implantable
reconstruction
different
ways
achieve
osteogenesis,
focus
on
various
applications
orthopedic
field.
More
specifically,
polymeric
together
their
fracture
healing,
vertebral
body
augmentation,
implant
fixation,
tumor
therapy,
bone-defect-related
infection
are
reviewed
detail.
Recent
progress
multiple
functionalities
bioresponsive
properties
is
also
reviewed.
Finally,
challenges
field
future
directions
clinical
treatment.
Journal of Bioactive and Compatible Polymers,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 13, 2025
The
treatment
of
large
segmental
bone
defects
has
always
been
a
difficult
problem
in
orthopedic
treatment,
which
is
characterized
by
local
microenvironment
with
impaired
blood
supply
and
absolute
or
relatively
insufficient
osteogenic
ability.
In
these
clinical
scenarios,
the
repair
process
often
hindered,
incidence
complications
increased.
Therefore,
obtaining
coordinated
angiogenesis
osteogenesis
will
be
an
effective
strategy.
this
study,
we
incorporated
ophiopogon
D
(OPD)
into
hydrogel
matrix
network
amino
polyethylene
glycol
sodium
alginate
oxide
as
raw
materials
to
construct
injectable
functional
biomaterial
for
promoting
differentiation.
vitro
studies
showed
that
constructed
material
had
satisfactory
injectability
self-healing
properties,
could
continuously
release
OPD
locally,
thus
migration
human
umbilical
vein
endothelial
cells
vitro,
differentiation
marrow
mesenchymal
stem
cells.
After
was
implanted
defect
radius
rabbit
model,
it
enhance
expression
angiogenic
protein,
improve
microenvironment,
accelerate
repair.
This
study
provides
new
strategy
theoretical
basis
design
minimally
invasive
tissue
engineering
defects.
Materials,
Journal Year:
2025,
Volume and Issue:
18(8), P. 1704 - 1704
Published: April 9, 2025
Different
treatments
have
been
proposed
for
morphofunctional
bone
repair;
however,
they
are
not
always
efficient
and
limitations.
In
this
experimental
study,
we
present
matrix
composites
with
a
possible
synergistic
effect
acting
scaffolds
growth
use
of
photobiomodulation
(PBM)
to
accelerate
tissue
repair.
Thus,
the
objective
was
evaluate
PBM
in
repair
long
(tibia)
rats
filled
biomimetic
collagen
matrices
nanohydroxyapatite
heterologous
fibrin
biopolymer
(FB).
Forty-eight
were
distributed
into
eight
groups
(n
=
six
each):
Blood
Clot
(BC),
+
(BCP),
Matrix
(M),
(MP),
Fibrin
Biopolymer
(FB),
(FBP),
FB
(MFB),
(MFBP).
A
2.0
mm
defect
created
proximal
third
left
tibia.
The
BCP,
MP,
FBP,
MFBP
underwent
during
surgery
maintained
twice
week
until
euthanasia
at
42
days.
Microcomputed
tomography
(micro-CT),
histomorphological
histomorphometric
analyses
performed.
Micro-CT
analysis
revealed
that
influenced
cortical
interposition
between
remnant
newly
formed
bone.
Histologically,
no
exacerbated
inflammatory
focus
or
foreign
body-type
granulomatous
reaction
observed
any
group;
vast
collagenous
more
oriented
thicker
spatial
conformation
PBM-treated
groups.
Histomorphometrically,
showed
significantly
higher
values
compared
other
Specifically,
BC
group
presented
mean
density
68.33
±
7.394,
while
BCP
MP
99.83
11.87
99.67
20.58,
respectively
(p
<
0.05).
Qualitative
fibers
indicated
enhanced
organization
maturation
This
study
concluded
association
bones
rats,
biopolymer,
results
contribute
improvement
growth,
together
scaffolds.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(20), P. 11092 - 11092
Published: Oct. 15, 2024
Mineralization
is
a
key
biological
process
that
required
for
the
development
and
repair
of
tissues
such
as
teeth,
bone
cartilage.
Exosomes
(Exo)
are
subset
extracellular
vesicles
(~50–150
nm)
secreted
by
cells
contain
genetic
material,
proteins,
lipids,
nucleic
acids,
other
substances
have
been
extensively
researched
oral
tissue
regeneration.
However,
Exo-free
biomaterials
or
exosome
treatments
exhibit
poor
bioavailability
lack
controlled
release
mechanisms
at
target
site
during
By
encapsulating
Exos
into
like
hydrogels,
these
disadvantages
can
be
mitigated.
Several
engineering
approaches,
those
wound
healing
processes
in
diabetes
mellitus,
treatment
osteoarthritis
(OA)
cartilage
degeneration,
intervertebral
disc
cardiovascular
diseases,
etc.,
exploited
to
deliver
exosomes
containing
variety
therapeutic
diagnostic
cargos
tissues.
Despite
significant
efficacy
Exo-laden
their
use
mineralized
tissues,
tissue,
very
sparse.
This
review
aims
explore
summarize
literature
related
potential
hydrogel-encapsulated
provides
insight
practical
procedures
future
clinical
techniques.
