Multifunctional nanomaterials composed entirely of active pharmaceutical ingredients for synergistically enhanced antitumor and antibacterial effects DOI Creative Commons

Qi An,

Dongmei Wang, Liang Huang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 21, 2024

Introduction Multifunctional nanomaterials are emerging as promising tools for treating both cancer and bacterial infections. However, integrating dual therapeutic capabilities into a single system remains challenging. This study presents multifunctional nanoparticles (ECI-NPs) based on Epigallocatechin gallate (EGCG) oligomers, Curcumin (CUR), Indocyanine Green (ICG) combined treatment. Methods ECI-NPs were synthesized via oxidative coupling of EGCG, CUR, ICG. The characterized stability, size, drug loading, release profiles. Cellular uptake, phototoxicity in melanoma cells, antibacterial activity against Escherichia coli Staphylococcus aureus also evaluated. Results demonstrated optimal high controlled release. studies showed increased uptake greater cells compared to free drugs. exhibited enhanced anticancer effects strong activity, outperforming the individual components. Discussion polyphenol-based offer synergistic effects, overcoming limitations drugs terms solubility efficacy. dual-function platform shows potential broader biomedical applications, addressing challenges Further research will focus vivo clinical translation.

Language: Английский

A Multifunctional γ-Polyglutamic Acid Hydrogel for Combined Tumor Photothermal and Chemotherapy DOI Creative Commons

Xiaoqing Jia,

Shige Wang

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 217 - 217

Published: March 20, 2025

Efficient and precise cancer therapy remains a challenge due to limitations in current treatment modalities. In this study, we developed multifunctional hydrogel system that integrates photothermal (PTT) chemotherapy achieve combined tumor treatment. The hydrogel, composed of γ-polyglutamic acid (γ-PGA), fifth-generation polyamide-amine dendrimers (G5), polydopamine (PDA) nanoparticles, exhibits high conversion efficiency temperature-responsive drug release properties. exhibited 45.6% under 808 nm near-infrared (NIR) irradiation. Drug studies demonstrated cumulative hydrophilic anticancer doxorubicin DOX 79.27% within 72 h mild hyperthermia conditions (50 °C). vivo experiments revealed significant inhibition rate 82.3% with minimal systemic toxicity. Comprehensive vitro evaluations reveal the demonstrates excellent biocompatibility, stability, biodegradability. Unlike conventional systems, our γ-PGA-based uniquely biocompatible biodegradable polymer providing smart responsive platform for therapy. This represents promising combines PTT precision efficacy, robust strategy advanced safer

Language: Английский

Citations

4
Unveiling the potential of inorganic nanoarchitecture-mediated photothermal therapy: An illustration on melanoma DOI

Aachal Hedaoo,

Pooja Khairnar,

Ganesh Vambhurkar

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 216, P. 113282 - 113282

Published: July 2, 2024

Language: Английский

Citations

5
Targeted Sonodynamic Therapy Platform for Holistic Integrative Helicobacter pylori Therapy DOI Creative Commons
Xiaojing Yin, Yongkang Lai, Xinyuan Zhang

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 13, 2024

Helicobacter pylori (H. pylori) is a primary pathogen associated with gastrointestinal diseases, including gastric cancer. The increase in resistance to antibiotics, along the adverse effects caused by complicated medication protocols, has made eradication of H. more formidable challenge, necessitating alternative therapeutics. Herein, targeted nanoplatform reported based on sonodynamic therapy, chitosan-conjugated fucose loaded indocyanine green (ICG@FCS). It penetrates mucosa and homes through dual targeting mechanisms: molecular via physical ultrasound. Upon ultrasound activation, it generates singlet oxygen, effectively attacking planktonic bacteria, disrupting biofilms, facilitating clearance intracellular bacteria promoting autophagy, multidrug-resistant strains. ICG@FCS minimally affects gut microbiota aids repair. holistic integrative therapy strategy proposed that targets while preserving health. This emphasizes importance maintaining patient health eradicating pathogen. advancement set refine comprehensive antibacterial approach, offering promising horizon ongoing battle against antibiotic effective cancer prevention strategies.

Language: Английский

Citations

5
Recent advances of injectable in situ-forming hydrogels for preventing postoperative tumor recurrence DOI Creative Commons

Zhanpeng Wang,

Bingtao Zhai,

Jing Sun

et al.

Drug Delivery, Journal Year: 2024, Volume and Issue: 31(1)

Published: Sept. 10, 2024

The unavoidable residual tumor tissue from surgery and the strong aggressiveness of cells pose challenges to postoperative treatment patients, accompanied by in situ recurrence decreased quality life. Therefore, there is an urgent need explore appropriate therapeutic strategies remove after inhibit metastasis surgery. In recent years, with rapid development biomedical materials, study local delivery systems as agents has gradually attracted attention researchers. Injectable situ-forming hydrogel a locally administered agent injected solution that can be loaded various rapidly gels form semi-solid gel at site. This type tightly fills surgical site covers irregular excision surfaces. this paper, we review advances application injectable hydrogels therapy, focusing on matrix materials its different types tumors, well discussing prospects clinical application.

Language: Английский

Citations

4
Multifunctional nanomaterials composed entirely of active pharmaceutical ingredients for synergistically enhanced antitumor and antibacterial effects DOI Creative Commons

Qi An,

Dongmei Wang, Liang Huang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 21, 2024

Introduction Multifunctional nanomaterials are emerging as promising tools for treating both cancer and bacterial infections. However, integrating dual therapeutic capabilities into a single system remains challenging. This study presents multifunctional nanoparticles (ECI-NPs) based on Epigallocatechin gallate (EGCG) oligomers, Curcumin (CUR), Indocyanine Green (ICG) combined treatment. Methods ECI-NPs were synthesized via oxidative coupling of EGCG, CUR, ICG. The characterized stability, size, drug loading, release profiles. Cellular uptake, phototoxicity in melanoma cells, antibacterial activity against Escherichia coli Staphylococcus aureus also evaluated. Results demonstrated optimal high controlled release. studies showed increased uptake greater cells compared to free drugs. exhibited enhanced anticancer effects strong activity, outperforming the individual components. Discussion polyphenol-based offer synergistic effects, overcoming limitations drugs terms solubility efficacy. dual-function platform shows potential broader biomedical applications, addressing challenges Further research will focus vivo clinical translation.

Language: Английский

Citations

2