DEVELOPMENT AND FORMULATION OF DRUG-LOADED HYDROGEL FOR CARTILAGE REGENERATIVE POTENTIAL DOI Creative Commons

S.R. Aravind,

T. S. Shanmugarajan

Journal Of Advanced Zoology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Bone defects resulting from trauma, disease, or congenital abnormalities represent a significant clinical challenge, necessitating advanced regenerative therapies. This study presents the development and formulation of drug-loaded hydrogel as novel approach for bone regeneration. The matrix is engineered to provide structural support controlled release therapeutic agents enhance healing. Various biocompatible polymers crosslinking strategies are investigated optimize hydrogel's mechanical properties, degradation kinetics, drug profiles. Furthermore, explores efficacy different drugs, growth factors, osteoinductive molecules in promoting osteogenesis tissue regeneration within scaffold. developed holds promise versatile platform addressing diverse advancing field orthopedics.

Language: Английский

Injectable hydrogels for cartilage and bone tissue regeneration: A review DOI
Parisa Ghandforoushan, Morteza Alehosseini, Nasim Golafshan

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 246, P. 125674 - 125674

Published: July 4, 2023

Language: Английский

Citations

50
A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials DOI Creative Commons
Hoon Choi, Wan-Sun Choi,

Jin-Oh Jeong

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 693 - 693

Published: Oct. 25, 2024

Hydrogels are known for their high water retention capacity and biocompatibility have become essential materials in tissue engineering drug delivery systems. This review explores recent advancements hydrogel technology, focusing on innovative types such as self-healing, tough, smart, hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited applications dynamic biomedical environments. Tough designed with enhanced mechanical properties, enabling use load-bearing cartilage regeneration. Smart respond external stimuli, including changes pH, temperature, electromagnetic fields, ideal controlled release tailored specific medical needs. Hybrid made from both natural synthetic polymers, combine bioactivity resilience, which is particularly valuable complex tissues. Despite these innovations, challenges optimizing biocompatibility, adjusting degradation rates, scaling up production remain. provides an in-depth analysis emerging technologies, highlighting transformative potential while outlining future directions development applications.

Language: Английский

Citations

12
Advances in Biomedical Applications of Solution Blow Spinning DOI Open Access

Javier Carriles,

Paul Nguewa, Gustavo González‐Gaitano

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14757 - 14757

Published: Sept. 29, 2023

In recent years, Solution Blow Spinning (SBS) has emerged as a new technology for the production of polymeric, nanocomposite, and ceramic materials in form nano microfibers, with similar features to those achieved by other procedures. The advantages SBS over spinning methods are fast generation fibers simplicity experimental setup that opens up possibility their on-site production. While producing large number nanofibers short time is crucial factor large-scale manufacturing, situ generation, example, sprayable, multifunctional dressings, capable releasing embedded active agents on wounded tissue, or use operating rooms prevent hemostasis during surgical interventions, open wide range possibilities. interest this evident from growing patents issued articles published last few years. Our focus review biomedicine-oriented applications based collection most relevant scientific papers date. Drug delivery, 3D culturing, regenerative medicine, fabrication biosensors some areas which been explored, frequently at proof-of-concept level. promising results obtained demonstrate potential biomedical pharmaceutical fields.

Language: Английский

Citations

19
Osteogenic Microenvironment Restoration around Dental Implants Induced by an Injectable MXene-Based Hydrogel DOI
Lin Chen, Cheng Tao,

D. Zhang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 13071 - 13088

Published: May 23, 2024

Peri-implantitis is an excessive inflammatory response induced by complex interactions between the bacteria, host immune system, and tissues around dental implant. Alveolar bone resorption caused peri-implantitis a significant cause of implant failure. However, to restore osteogenic microenvironment, multifaceted therapeutic method that simultaneously encompasses anti-inflammatory tissue regenerative strategies indispensable. In this study, temperature-sensitive hydrogel (FMXO) loaded with MXene MgO was used develop multifunctional injectable MXene-based hydrogel. This could release in irregular defect areas situ no toxicity, either vitro or vivo. Our results showed FMXO effectively inhibited NF-κB signaling pathway RAW264.7 cells upregulated expression ALP, Runx2, OCN marrow mesenchymal stromal (BMSCs). Therefore, exerted pharmacological effects on inflammation regeneration. Moreover, we found FMXO, when exposed near-infrared (NIR) light, exhibited high efficacy against Porphyromonas gingivalis, Fusobacterium nucleatum, their plaque microorganisms, which were considered initiating factors peri-implantitis. The multifunctionality also confirmed immediate peri-implant rat model vivo, suggesting great potential for therapy clinic.

Language: Английский

Citations

7
Multifunctional hydrogels based on photothermal therapy: A prospective platform for the postoperative management of melanoma DOI

Wen-Shang Liu,

Zhuo Chen, Zhengmao Lu

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 371, P. 406 - 428

Published: June 8, 2024

Language: Английский

Citations

6
Minimally Invasive Implantable Biomaterials for Bone Reconstruction DOI Creative Commons

Feng Han,

Zhao Liu,

Qiang Wei

et al.

Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Bone injuries induced by accidents or bone-related disease have dramatically increased in the past decades. The application of biomaterials has become an inextricable part treatment for new bone formation and regeneration. Different from traditional bone-regeneration materials, injectable biomaterials-ranging bioceramics to polymers-have been applied as a means promoting surgery with minimal intervention approach. In this review, we summarize most recent developments minimally invasive implantable reconstruction different ways achieve osteogenesis, focus on various applications orthopedic field. More specifically, polymeric together their fracture healing, vertebral body augmentation, implant fixation, tumor therapy, bone-defect-related infection are reviewed detail. Recent progress multiple functionalities bioresponsive properties is also reviewed. Finally, challenges field future directions clinical treatment.

Language: Английский

Citations

5
Functionalized hydrogels promote the repair of large segmental bone defects by simultaneously regulating angiogenesis and osteogenesis DOI

B. Liu,

Yongliang Tang, Li Ni

et al.

Journal of Bioactive and Compatible Polymers, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

The treatment of large segmental bone defects has always been a difficult problem in orthopedic treatment, which is characterized by local microenvironment with impaired blood supply and absolute or relatively insufficient osteogenic ability. In these clinical scenarios, the repair process often hindered, incidence complications increased. Therefore, obtaining coordinated angiogenesis osteogenesis will be an effective strategy. this study, we incorporated ophiopogon D (OPD) into hydrogel matrix network amino polyethylene glycol sodium alginate oxide as raw materials to construct injectable functional biomaterial for promoting differentiation. vitro studies showed that constructed material had satisfactory injectability self-healing properties, could continuously release OPD locally, thus migration human umbilical vein endothelial cells vitro, differentiation marrow mesenchymal stem cells. After was implanted defect radius rabbit model, it enhance expression angiogenic protein, improve microenvironment, accelerate repair. This study provides new strategy theoretical basis design minimally invasive tissue engineering defects.

Language: Английский

Citations

0
In vivo analysis of hybrid hydrogels containing dual growth factor combinations, and skeletal stem cells under mechanical stimulation for bone repair DOI Creative Commons

David Gothard,

Michael Rotherham, Emma L. Smith

et al.

Mechanobiology in Medicine, Journal Year: 2024, Volume and Issue: 2(4), P. 100096 - 100096

Published: Aug. 27, 2024

Bone tissue engineering requires a combination of materials, cells, growth factors and mechanical cues to recapitulate bone formation. In this study we evaluated hybrid hydrogels for minimally invasive formation by combining biomaterials with skeletal stem cells staged release together mechanotransduction. Hybrid consisting alginate decellularized, demineralised extracellular matrix (ALG/ECM) were seeded Stro-1+ human marrow stromal (HBMSCs). Dual combinations within staged-release polylactic-co-glycolic acid (PLGA) microparticles added mimic, in part, the signalling events regeneration: VEGF, TGF-β3, PTHrP (fast release), or BMP-2, vitamin D3 (slow release). Mechanotransduction was initiated using magnetic fields remotely actuate superparamagnetic nanoparticles (MNP) targeted TREK1 ion channels. implanted subcutaneously mice 28 days, micro-CT histology. Control lacking HBMSCs, factors, MNP became mineralised, neither nor mechanotransduction increased However, structural differences newly-formed influenced factors. Slow BMP-2 induced thick trabeculae VitD3 fast-release TGF-β3 VEGF resulted thin trabeculae. reversed trabecular thinning collagen deposition VitD3. Our findings demonstrate potential ALG/ECM hydrogel–cell–growth factor constructs repair fine-tuning structure. This approach may form reparative strategy applications.

Language: Английский

Citations

3
Exosome-Laden Hydrogels as Promising Carriers for Oral and Bone Tissue Engineering: Insight into Cell-Free Drug Delivery DOI Open Access

Cassandra Villani,

Murugan Prasathkumar, Anne George

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11092 - 11092

Published: Oct. 15, 2024

Mineralization is a key biological process that required for the development and repair of tissues such as teeth, bone cartilage. Exosomes (Exo) are subset extracellular vesicles (~50–150 nm) secreted by cells contain genetic material, proteins, lipids, nucleic acids, other substances have been extensively researched oral tissue regeneration. However, Exo-free biomaterials or exosome treatments exhibit poor bioavailability lack controlled release mechanisms at target site during By encapsulating Exos into like hydrogels, these disadvantages can be mitigated. Several engineering approaches, those wound healing processes in diabetes mellitus, treatment osteoarthritis (OA) cartilage degeneration, intervertebral disc cardiovascular diseases, etc., exploited to deliver exosomes containing variety therapeutic diagnostic cargos tissues. Despite significant efficacy Exo-laden their use mineralized tissues, tissue, very sparse. This review aims explore summarize literature related potential hydrogel-encapsulated provides insight practical procedures future clinical techniques.

Language: Английский

Citations

3
Quercetin-Based Biomaterials for Enhanced Bone Regeneration and Tissue Engineering DOI

Mohammad-Sadegh Lotfi,

Mohammad Sheibani, Majid Jafari‐Sabet

et al.

Tissue and Cell, Journal Year: 2024, Volume and Issue: 91, P. 102626 - 102626

Published: Nov. 20, 2024

Language: Английский

Citations

3