SERS-based microdevices for use as in vitro diagnostic biosensors

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(11), P. 5394 - 5427

Published: Jan. 1, 2024

This review explores various microdevices developed for applying SERS technology to in vitro diagnostics and delves into their clinical applications.

Language: Английский

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Numerical analysis of an advanced infrared-based graphene metasurface surface plasmon resonance sensor for COVID-19 detection

Diamond and Related Materials, Journal Year: 2024, Volume and Issue: unknown, P. 111601 - 111601

Published: Sept. 1, 2024

Language: Английский

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Graphene Metasurfaces-Based Surface Plasmon Resonance Biosensor for Virus Detection with Sensitivity Enhancement Using Perovskite Materials

Plasmonics, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 14, 2024

Language: Английский

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Label‐free surface‐enhanced Raman spectroscopy coupled with machine learning algorithms in pathogenic microbial identification: Current trends, challenges, and perspectives

Deleted Journal, Journal Year: 2024, Volume and Issue: 2(3)

Published: March 5, 2024

Abstract Infectious diseases caused by microbial pathogens remain a primary contributor to global health burdens. Prompt control and effective prevention of these are critical for public medical diagnostics. Conventional detection methods suffer from high complexity, low sensitivity, poor selectivity. Therefore, developing rapid reliable pathogen has become imperative. Surface‐enhanced Raman Spectroscopy (SERS), as an innovative non‐invasive diagnostic technique, holds significant promise in pathogenic microorganism due its rapid, reliable, cost‐effective advantages. This review comprehensively outlines the fundamental theories (RS) with focus on label‐free SERS strategy, reporting latest advancements technique detecting bacteria, viruses, fungi clinical settings. Furthermore, we emphasize application machine learning algorithms spectral analysis. Finally, challenges faced probed, prospective development is discussed.

Language: Английский

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A Review on Photonic Sensing Technologies: Status and Outlook

Biosensors, Journal Year: 2023, Volume and Issue: 13(5), P. 568 - 568

Published: May 22, 2023

In contemporary science and technology, photonic sensors are essential. They may be made to extremely resistant some physical parameters while also being sensitive other variables. Most incorporated on chips operate with CMOS making them suitable for use as sensitive, compact, affordable sensors. Photonic can detect electromagnetic (EM) wave changes convert into an electric signal due the photoelectric effect. Depending requirements, scientists have found ways develop based several interesting platforms. this work, we extensively review most generally utilized detecting vital environmental personal health care. These sensing systems include optical waveguides, fibers, plasmonics, metasurfaces, crystals. Various aspects of light used investigate transmission or reflection spectra general, resonant cavity grating-based sensor configurations that work wavelength interrogation methods preferred, so these types mostly presented. We believe paper will provide insight novel available

Language: Английский

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Mosaic quadrivalent influenza vaccine single nanoparticle characterization

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 24, 2024

Abstract Recent work by our laboratory and others indicates that co-display of multiple antigens on protein-based nanoparticles may be key to induce cross-reactive antibodies provide broad protection against disease. To reach the ultimate goal a universal vaccine for seasonal influenza, mosaic influenza nanoparticle (FluMos-v1) was developed clinical trial (NCT04896086). FluMos-v1 is unique in it designed four recently circulating haemagglutinin (HA) strains; however, current analysis techniques are limited population analysis, thus, unable determine valency an individual nanoparticle. For first time, we demonstrate total internal reflection fluorescence microscopy supportive physical–chemical methods indeed achieved single nanoparticles. Additionally, have determined percentages multivalent (mosaic) with four, three, or two HA proteins. The integrated imaging physicochemical multivalency will serve further understand immunogenicity data from trial.

Language: Английский

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Multimodal Biosensing of Foodborne Pathogens

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5959 - 5959

Published: May 29, 2024

Microbial foodborne pathogens present significant challenges to public health and the food industry, requiring rapid accurate detection methods prevent infections ensure safety. Conventional single biosensing techniques often exhibit limitations in terms of sensitivity, specificity, rapidity. In response, there has been a growing interest multimodal approaches that combine multiple sensing enhance efficacy, accuracy, precision detecting these pathogens. This review investigates current state technologies their potential applications within industry. Various platforms, such as opto-electrochemical, optical nanomaterial, nanomaterial-based systems, hybrid microfluidics, microfabrication are discussed. The provides an in-depth analysis advantages, challenges, future prospects for pathogens, emphasizing its transformative safety health. comprehensive aims contribute development innovative strategies combating ensuring reliability global supply chain.

Language: Английский

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表面增强拉曼光谱技术在流行性病毒检测领域的研究进展

Chinese Journal of Lasers, Journal Year: 2024, Volume and Issue: 51(9), P. 0907006 - 0907006

Published: Jan. 1, 2024

近几年新型冠状病毒COVID-19的迅速传播,引起了全球对传染病防控和快速病毒检测技术的高度关注。表面增强拉曼光谱(SERS)作为一种光学分析技术,凭借其独特的分子指纹特性和高检测灵敏度的特点,成为生物医学检测领域的有力工具,对可能大规模暴发的流行性病毒灵敏迅速的检测以及监控提供新颖、高效的光学解决方案。本文对从2021年以来开展的DNA、RNA病毒,尤其是威胁人类生命健康的流行性病毒检测工作当中使用的标记、非标记SERS技术进行梳理,从SERS基底结构建构及功能化修饰,分子探针的设计,高速响应、高灵敏度检测模型构建,生物技术、机器学习方法的联合使用等方面,特别是基于便携式、手持式拉曼光谱仪的研究,对SERS技术在病毒检测领域的应用进展进行了总结和展望。

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Phenotypic, molecular and serological detection of viral diseases in melon: a comprehensive review on progress and challenges

Journal of Plant Diseases and Protection, Journal Year: 2025, Volume and Issue: 132(1)

Published: Jan. 6, 2025

Language: Английский

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Raman signatures of type A and B influenza viruses: molecular origin of the “catch and kill” inactivation mechanism mediated by micrometric silicon nitride powder

RSC Chemical Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Raman multiomics gives unique insight into the structural characteristics of type A and B influenza viruses. Si 3 N 4 fine powder completely inactivates virus strains by a mechanism that poisons them with hydrolytic ammonia locally enhances pH.

Language: Английский

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