Frontiers in Neurology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 28, 2025
Hemiplegia
severely
impairs
patients'
abilities
to
perform
activities
of
daily
living
(ADL),
thus
affecting
their
overall
quality
life
and
independence.
Often
caused
by
stroke
or
other
forms
brain
injury,
hemiparesis
causes
long-term
impairment
upper
lower
limb
function,
hindering
the
patient's
ability
manage
self-care.
With
advances
in
modern
rehabilitation
medicine,
emerging
therapeutic
interventions
such
as
electrophysiological
feedback,
virtual
reality,
robot-assisted
therapy
are
increasingly
being
applied
hemiplegic
patients.
These
interventions,
combined
with
precise
technical
support
through
individualized
training,
have
been
shown
be
effective
improving
function
well
enhancing
ADL
This
paper
reviews
recent
assesses
impact
on
performance,
examines
effectiveness
functional
outcomes
for
findings
suggest
that
approaches
significant
clinical
potential
provide
more
personalized
treatment
strategies
people
hemiplegia.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 15, 2024
AIM2,
a
cytosolic
innate
immune
receptor,
has
the
capability
to
recognize
double-stranded
DNA
(dsDNA).
This
paper
delineates
structural
features
of
AIM2
and
its
mechanisms
activation,
emphasizing
capacity
detect
initiate
inflammasome
assembly.
Additionally,
we
explore
diverse
functions
in
different
cells.
Insights
into
AIM2-mediated
neuroinflammation
provide
foundation
for
investigating
novel
therapeutic
strategies
targeting
signaling
pathways.
Furthermore,
present
comprehensive
review
roles
neurodegenerative
diseases,
including
Alzheimer’s
disease
(AD)
Parkinson’s
(PD).
Finally,
discuss
implications.
In
conclusion,
profound
understanding
diseases
may
facilitate
development
effective
interventions
mitigate
neuronal
damage
slow
progression.
Cells,
Journal Year:
2024,
Volume and Issue:
13(18), P. 1554 - 1554
Published: Sept. 15, 2024
Intercellular
adhesion
molecule
1
(ICAM-1/CD54),
a
transmembrane
glycoprotein,
has
been
considered
as
one
of
the
most
important
molecules
during
leukocyte
recruitment.
It
is
encoded
by
ICAM1
gene
and
plays
central
role
in
inflammation.
Its
crucial
many
inflammatory
diseases
such
ulcerative
colitis
rheumatoid
arthritis
are
well
established.
Given
that
neuroinflammation,
underscored
microglial
activation,
key
element
neurodegenerative
Parkinson’s
disease
(PD),
we
investigated
whether
ICAM-1
this
progressive
neurological
condition
and,
if
so,
to
elucidate
underpinning
mechanisms.
Specifically,
were
interested
potential
interaction
between
ICAM-1,
glial
cells,
ferroptosis,
an
iron-dependent
form
cell
death
recently
implicated
PD.
We
conclude
there
exist
direct
indirect
(via
cells
T
cells)
influences
on
ferroptosis
further
elucidation
these
interactions
can
suggest
novel
intervention
for
devastating
disease.
Viruses,
Journal Year:
2024,
Volume and Issue:
16(12), P. 1811 - 1811
Published: Nov. 21, 2024
The
COVID-19
outbreak,
caused
by
the
SARS-CoV-2
virus,
was
linked
to
significant
neurological
and
psychiatric
manifestations.
This
review
examines
physiopathological
mechanisms
underlying
these
neuropsychiatric
outcomes
discusses
current
management
strategies.
Primarily
a
respiratory
disease,
frequently
leads
issues,
including
cephalalgia
migraines,
loss
of
sensory
perception,
cerebrovascular
accidents,
impairment
such
as
encephalopathy.
Lasting
neuropsychological
effects
have
also
been
recorded
in
individuals
following
infection.
These
include
anxiety,
depression,
cognitive
dysfunction,
suggesting
lasting
impact
on
mental
health.
neuroinvasive
potential
inflammatory
responses,
role
angiotensin-converting
enzyme
2
(ACE2)
neuroinflammation
are
critical
factors
In
addition,
highlights
importance
monitoring
biomarkers
assess
Central
Nervous
System
(CNS)
involvement.
Management
strategies
for
conditions
supportive
therapy,
antiepileptic
drugs,
antithrombotic
psychotropic
emphasizing
need
multidisciplinary
approach.
Understanding
long-term
implications
is
essential
developing
effective
treatment
protocols
improving
patient
outcomes.
