Biocatalysis and Agricultural Biotechnology, Journal Year: 2023, Volume and Issue: 51, P. 102803 - 102803
Published: July 29, 2023
Language: Английский
Applied Sciences, Journal Year: 2022, Volume and Issue: 12(1), P. 455 - 455
Published: Jan. 4, 2022
Nowadays, food is no longer just for nutrition. Consumers are more demanding and expect to get health benefits from their daily meals. Various areas of the industry in great demand functional chemicals enhance taste nutritional value products. Probiotic bacteria have already been part human’s routine good gut microbiota maintenance terms pharmaceutical Their incorporation however a challenging task that offers opportunities but has limitations as well. Specifically, purpose this review emphasize importance probiotics food, assess survival through gastrointestinal tract, highlight recent advances approaches improved viability.
Language: Английский
Citations
74
Nanomaterials, Journal Year: 2023, Volume and Issue: 13(15), P. 2185 - 2185
Published: July 27, 2023
Probiotics have garnered significant attention in recent years due to their potential advantages diverse biomedical applications, such as acting antimicrobial agents, aiding tissue repair, and treating diseases. These live bacteria must exist appropriate quantities precise locations exert beneficial effects. However, viability activity can be significantly impacted by the surrounding tissue, posing a challenge maintain stability target location for an extended duration. To counter this, researchers formulated various strategies that enhance of probiotics encapsulating them within biomaterials. This approach enables site-specific release, overcoming technical impediments encountered during processing application probiotics. A range materials utilized probiotics, several methods employed this encapsulation process. article reviews advancements encapsulated biomaterials, examining materials, methods, effects encapsulation. It also provides overview hurdles faced currently available biomaterial-based probiotic capsules suggests future research directions field. Despite progress achieved date, numerous challenges persist, necessity developing efficient, reproducible Furthermore, there is need design more robust targeted delivery vehicles.
Language: Английский
Citations
58
Microorganisms, Journal Year: 2024, Volume and Issue: 12(3), P. 430 - 430
Published: Feb. 20, 2024
Next-generation probiotics (NGPs) represent an innovative group of beneficial bacteria that are currently undergoing research and development. NGPs designed not only for conventional use as foods or dietary supplements but also tailored pharmaceutical applications. Research indicates show therapeutic promise in addressing various chronic ailments. Offering multiple advantages over probiotics, present opportunities personalized probiotic therapies, involvement synthetic biology gene editing, participation combination targeted delivery methods, application settings. Our review discusses the potential effect NGPs, covering diverse trajectories including their identification, characterization, delivery. Furthermore, this elucidates influence on critical aspects human health, specifically, gut immune function, broader health outcomes. Mechanistic insights encompass production bioactive compounds, competitive interactions with pathogenic bacteria, modulation cell activity, reinforcement barrier. What is noteworthy current points out prevalent NGP strains sources, providing a highlight comprehensive framework understanding applications future benefits domain advanced therapeutics.
Language: Английский
Citations
51
Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(4), P. 528 - 528
Published: April 1, 2023
The immune system protects the body from infectious agents such as bacteria, viruses, or fungi. Once encountered with pathogens antigens, innate and adaptive arms of trigger a strong response to eliminate them protect body. Thus, well-balanced immunity is pivotal for maintaining human health, an insufficient level defense leads infections tumors. In contrast, excessive functioning causes development autoimmune diseases allergies. Strong requires adequate nutrition, dietary interventions, sufficient intake certain vitamins (vitamin C, vitamin D, folic acid) minerals (magnesium, zinc, selenium). Therefore, nutritional micronutrient deficiencies lead compromised immunity. Several natural ingredients have shown potent immunomodulatory properties. immune-enhancing properties many plants fungi are due containing bioactive phytoconstituents polyphenols, terpenoids, β-glucans, vitamins, etc. Probiotics prebiotics can be used innovative tools reduce intestinal inflammation downregulate hypersensitivity reactions. Plant sources melatonin, multifunctional molecule proven anti-inflammatory properties, been discovered relatively recently. compounds augment by directly increasing cytotoxic activity killer cells, macrophages, neutrophils. Many prevent cell damage their powerful antimicrobial, antioxidant, present review attempts understand molecular mechanisms underlying some plants, fungi, animals, microorganisms, other sources.
Language: Английский
Citations
44
ACS Omega, Journal Year: 2024, Volume and Issue: 9(28), P. 29966 - 29982
Published: July 5, 2024
Nanobiotechnology has ushered in a new era of scientific discovery where the unique properties nanomaterials, such as gold nanoparticles, have been harnessed for wide array applications. This review explores nanoparticles' synthesis, properties, and multidisciplinary applications, focusing on their role biosensors. Gold nanoparticles possess exceptional physicochemical attributes, including size-dependent optical biocompatibility, ease functionalization, making them promising candidates development biosensing platforms. The begins by providing comprehensive overview nanoparticle synthesis techniques, highlighting advantages disadvantages various approaches. It then delves into remarkable that underpin success biosensing, localized surface plasmon resonance enhanced area. discussion also includes functionalization strategies enable specific binding to biomolecules, enhancing sensitivity selectivity gold-nanoparticle-based Furthermore, this surveys diverse applications encompassing diagnostics, environmental monitoring, drug delivery. nature these underscores versatility potential addressing complex challenges healthcare science. emphasizes pressing need further exploration research field nanobiotechnology, particularly regarding nanoparticles. With attributes versatile functionalities, present avenue science, it imperative advance our understanding capabilities broader innovation.
Language: Английский
Citations
34
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)
Published: Jan. 21, 2024
Probiotics with diverse and crucial properties functions have attracted broad interest from many researchers, who adopt intestinal delivery of probiotics to modulate the gut microbiota. However, major problems faced for therapeutic applications are viability colonization during their processing, oral intake, subsequent gut. The challenges simple (stability, controllability, targeting, etc.) greatly limited use in clinical therapies. Nanotechnology can endow be delivered intestine improved survival rate increased resistance adverse environment. Additionally, progress synthetic biology has created new opportunities efficiently purposefully designing manipulating probiotics. In this article, a brief overview types delivery, current different probiotic encapsulation strategies, including chemical, physical, genetic strategies combinations, emerging single-cell using nanocoating methods, is presented. action mechanisms that responsible eliciting beneficial effects also briefly discussed. Finally, engineered discussed, future trends toward developing advanced features health benefits proposed.
Language: Английский
Citations
24
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 185 - 185
Published: Feb. 2, 2025
Probiotics provide significant health benefits, but their viability is often compromised during production, storage, and passage through the gastrointestinal tract. These challenges hinder effective incorporation into functional applications, particularly in dairy foods, which factors such as acidity, oxygen exposure, storage conditions negatively impact cell survival. The focus was on pasta filata cheeses. Indeed, use of probiotics cheeses presents due to specific manufacturing processes, encompass application high temperatures other harsh conditions. can adversely affect availability probiotic microorganisms. However, microencapsulation has emerged a promising solution, offering protective barrier that enhances stability, improves survival rates, facilitates targeted release environment. This review examines pivotal role stabilising for emphasising its relevance high-value food systems. Functional including foods designed offer essential nutritional benefits promote host health, play crucial disease prevention immune system support, reducing risk infections physiological impairments. Key technologies are analysed, focusing limitations, related scalability industrial implementation. Additionally, this discusses strategies optimise formulations, ensure sensory quality final products, explore future opportunities expanding innovative applications align with growing consumer demand health-promoting solutions.
Language: Английский
Citations
2
Foods, Journal Year: 2022, Volume and Issue: 11(16), P. 2472 - 2472
Published: Aug. 16, 2022
The probiotics market is one of the fastest growing segments food industry as there scientific evidence positive health effects on consumers. Currently, are various forms probiotic products and they can be categorized according to dosage form site action. To increase effectiveness preparations, need specifically designed so target different sites, such oral, upper respiratory or gastrointestinal tracts. Here we review characteristics discuss methods improve their bioavailability in detail, hope that this article will provide a reference for development products.
Language: Английский
Citations
67
Biocatalysis and Agricultural Biotechnology, Journal Year: 2023, Volume and Issue: 53, P. 102889 - 102889
Published: Oct. 1, 2023
Language: Английский
Citations
23
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: March 27, 2024
Obesity and chronic low-grade inflammation, often occurring together, significantly contribute to severe metabolic inflammatory conditions like type 2 diabetes (T2D), cardiovascular disease (CVD), cancer. A key player is elevated levels of gut dysbiosis-associated lipopolysaccharide (LPS), which disrupts immune signaling leading endotoxemia, while short-chain fatty acids (SCFAs) beneficially regulate these processes during homeostasis. SCFAs not only safeguard the barrier but also exert immunomodulatory effects via G protein-coupled receptor binding epigenetic regulation. are emerging as potential agents counteract dysbiosis-induced changes, specifically targeting genes through DNA methylation, histone acetylation, microRNAs (miRNAs), long non-coding RNAs (lncRNAs). To assess whether can effectively interrupt detrimental cascade obesity this review aims provide a comprehensive overview current evidence for their clinical application. The emphasizes factors influencing SCFA production, intricate connections between metabolism, system, microbiome, mechanisms regulated by that impact metabolism system.
Language: Английский
Citations
15