Akkermansia muciniphila helps in the recovery of lipopolysaccharide-fed mice with mild intestinal dysfunction DOI Creative Commons
Yue Hu,

Jun Zhou,

Xiaoqi Lin

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: March 12, 2025

Background Mild intestinal dysfunction, linked to subtle yet significant health issues, can be induced by lipopolysaccharide (LPS), a Gram-negative bacterial component that disrupts gut function and triggers inflammation. Akkermansia muciniphila has shown promise as probiotic for due its roles in mucin degradation short-chain fatty acid production. This study explores the therapeutic effects of on LPS-induced mild dysfunction mice. Methods Thirty-eight 6-week-old C57BL/6 mice were split into control ( n = 19) LPS-treated groups. received 300 μg/kg/day LPS 4 weeks, followed supplementation at 41 mg/kg/day (Akk1) or 82 (Akk2) another weeks. Gut microbiota was analyzed via metagenomic sequencing, gene expression evaluated through transcriptomics. Results significantly altered microbiota, reducing diversity increasing pathogenic genera like Lachnoclostridium. supplementation, particularly higher doses, partially restored beneficial such Muribaculum. Transcriptomics showed immune inflammatory responses, while reduced these modulating pathways TNF NF-kappa B signaling. Conclusion mitigates restoring balance highlighting potential agent health.

Language: Английский

Probiotics and Food Bioactives: Unraveling Their Impact on Gut Microbiome, Inflammation, and Metabolic Health DOI
Alice Njolke Mafe, Great Iruoghene Edo, Patrick Othuke Akpoghelie

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Language: Английский

Citations

8

A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses DOI Creative Commons
Alice Njolke Mafe, Great Iruoghene Edo,

Osamah S. Majeed

et al.

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919

Published: Feb. 11, 2025

Language: Английский

Citations

6

Microbiome-Driven Therapeutics: From Gut Health to Precision Medicine DOI Creative Commons
Muneer Yaqub,

Aashika Jain,

Chinedu Eucharia Joseph

et al.

Gastrointestinal Disorders, Journal Year: 2025, Volume and Issue: 7(1), P. 7 - 7

Published: Jan. 15, 2025

The human microbiome, a complex ecosystem of microorganisms residing in and on the body, plays pivotal role regulation wide range physiological processes, including digestion, immune responses, metabolic functions. In recent years, rapidly growing field microbiome-driven therapeutics has garnered significant attention owing to its potential revolutionize healthcare. This review explores evolving landscape microbiome-based therapies, with particular focus gut microbiome implications for both health precision medicine. We highlight advances understanding how microbial communities influence disease pathogenesis treatment outcomes, spanning conditions such as inflammatory bowel (IBD), disorders, neurological diseases, even cancer. article also discusses emerging therapeutic strategies, probiotics, prebiotics, fecal microbiota transplantation (FMT), microbial-based drugs, well challenges associated their clinical implementation. Additionally, we examined integration profiling metagenomic data is advancing medicine, paving way personalized effective treatments. serves comprehensive resource that synthesizes current knowledge, identifies key gaps research, offers insights into future direction therapeutics, thus providing valuable framework clinicians, researchers, policymakers seeking harness microbiomes advance healthcare solutions.

Language: Английский

Citations

4

Antimicrobial Activity of Probiotic Bacteria Isolated from Plants: A Review DOI Creative Commons
Anshul Sharma, Hae‐Jeung Lee

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 495 - 495

Published: Feb. 4, 2025

Lactic acid bacteria (LAB) constitute a heterogeneous group of isolated from fermented foods, animals, plants, and mammalian guts, with many health-promoting properties. Probiotics antagonistic properties against human pathogens foodborne have garnered significant attention the scientific fraternity. A dedicated review focusing on plant-derived probiotic their has not been comprehensively reviewed. Thus, this aimed at providing an overview LAB isolates derived several unconventional sources such as fruits, seeds, fruit pulp, leaves, roots, vegetables, grasses, flowers antibacterial, antifungal, antiviral This paper reviewed antimicrobial different genera, Lactobacillus, Leuconostoc, Weissella, Enterococcus, Pediococcus, Bacillus, Fructobacillus, postbiotics, paraprobiotics. Several important mechanisms, including secretion bacteriocins, bacteriocin-like substances, reuterin, organic acids (lactic acetic), peptides, exopolysaccharides, hydrogen peroxide, attributed to actions pathogens. However, precise mode action is poorly understood; hence, further research should be conducted reveal detailed mechanisms. Finally, discusses summary future implications. Given significance, compounds can potentially exploited in food preservation safety or for medicinal applications after evaluating safety.

Language: Английский

Citations

3

Lactic acid bacteria: Nature, Characterization, Mode of action, Products and Applications DOI
Patrick Othuke Akpoghelie, Great Iruoghene Edo,

Ali B.M. Ali

et al.

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

3

Where Biology Meets Engineering: Scaling Up Microbial Nutraceuticals to Bridge Nutrition, Therapeutics, and Global Impact DOI Creative Commons
Ahmed M. Elazzazy, Mohammed N. Baeshen,

Khalid M. Alasmi

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 566 - 566

Published: March 2, 2025

The global nutraceutical industry is experiencing a paradigm shift, driven by an increasing demand for functional foods and dietary supplements that address malnutrition chronic diseases such as obesity, diabetes, cardiovascular conditions, cancer. Traditional plant- animal-derived nutraceuticals face limitations in scalability, cost, environmental impact, paving the way microbial biotechnology sustainable alternative. Microbial cells act bio-factories, converting nutrients like glucose amino acids into valuable products polyunsaturated fatty (PUFAs), peptides, other bioactive compounds. By harnessing their natural metabolic capabilities, microorganisms efficiently synthesize these compounds, making production effective approach development. This review explores transformative role of platforms nutraceuticals, emphasizing advanced fermentation techniques, synthetic biology, engineering. It addresses challenges optimizing strains, ensuring product quality, scaling while navigating regulatory frameworks. Furthermore, highlights cutting-edge technologies CRISPR/Cas9 genome editing, adaptive evolution strain enhancement, bioreactor innovations to enhance yield efficiency. With focus on sustainability precision, positioned game-changer industry, offering eco-friendly scalable solutions meet health needs. integration omics exploration novel sources hold potential revolutionize this field, aligning with growing consumer innovative products.

Language: Английский

Citations

2

Impact of Metabolites from Foodborne Pathogens on Cancer DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3886 - 3886

Published: Dec. 1, 2024

Foodborne pathogens are microorganisms that cause illness through contamination, presenting significant risks to public health and food safety. This review explores the metabolites produced by these pathogens, including toxins secondary metabolites, their implications for human health, particularly concerning cancer risk. We examine various such as Salmonella sp., Campylobacter Escherichia coli, Listeria monocytogenes, detailing specific of concern carcinogenic mechanisms. study discusses analytical techniques detecting chromatography, spectrometry, immunoassays, along with challenges associated detection. covers effective control strategies, processing techniques, sanitation practices, regulatory measures, emerging technologies in pathogen control. manuscript considers broader highlighting importance robust policies, awareness, education. identifies research gaps innovative approaches, recommending advancements detection methods, preventive policy improvements better manage foodborne metabolites.

Language: Английский

Citations

11

Harnessing the Health and Techno-Functional Potential of Lactic Acid Bacteria: A Comprehensive Review DOI Creative Commons
Lamia Ayed,

Sana M’hir,

Domenico Nuzzolese

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(10), P. 1538 - 1538

Published: May 15, 2024

This review examines the techno-functional properties of lactic acid bacteria (LABs) in food industry, focusing on their potential health benefits. We discuss current findings related to techno-functionality LAB, which includes acidification, proteolytic and lipolytic features, a variety other biochemical activities. These activities include production antimicrobial compounds synthesis exopolysaccharides that improve safety consumer sensory experience. LABs are also known for antioxidant abilities, help reduce oxidative reactions foods functional properties. In addition, LABs’ role as probiotics is promising effects gut health, immune system modulation, cholesterol control, general wellbeing. Despite these advantages, several challenges hinder effective use probiotic LABs, such maintaining strain viability during storage transport well ensuring efficacy gastrointestinal tract. Our identifies critical barriers suggests avenues future research.

Language: Английский

Citations

9

Microbial Contamination of Food: Probiotics and Postbiotics as Potential Biopreservatives DOI Creative Commons
Gordana Zavišić, Slavica Ristić, Saša Petričević

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(16), P. 2487 - 2487

Published: Aug. 8, 2024

Microbial contamination of food and alimentary toxoinfection/intoxication in humans are commonly caused by bacteria such as

Language: Английский

Citations

9

Chitosan and its derivatives: A novel approach to gut microbiota modulation and immune system enhancement DOI
Great Iruoghene Edo, Alice Njolke Mafe,

Ali B. M. Ali

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138633 - 138633

Published: Dec. 13, 2024

Language: Английский

Citations

9