Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 12, 2025
Background
Mild
intestinal
dysfunction,
linked
to
subtle
yet
significant
health
issues,
can
be
induced
by
lipopolysaccharide
(LPS),
a
Gram-negative
bacterial
component
that
disrupts
gut
function
and
triggers
inflammation.
Akkermansia
muciniphila
has
shown
promise
as
probiotic
for
due
its
roles
in
mucin
degradation
short-chain
fatty
acid
production.
This
study
explores
the
therapeutic
effects
of
on
LPS-induced
mild
dysfunction
mice.
Methods
Thirty-eight
6-week-old
C57BL/6
mice
were
split
into
control
(
n
=
19)
LPS-treated
groups.
received
300
μg/kg/day
LPS
4
weeks,
followed
supplementation
at
41
mg/kg/day
(Akk1)
or
82
(Akk2)
another
weeks.
Gut
microbiota
was
analyzed
via
metagenomic
sequencing,
gene
expression
evaluated
through
transcriptomics.
Results
significantly
altered
microbiota,
reducing
diversity
increasing
pathogenic
genera
like
Lachnoclostridium.
supplementation,
particularly
higher
doses,
partially
restored
beneficial
such
Muribaculum.
Transcriptomics
showed
immune
inflammatory
responses,
while
reduced
these
modulating
pathways
TNF
NF-kappa
B
signaling.
Conclusion
mitigates
restoring
balance
highlighting
potential
agent
health.
Gastrointestinal Disorders,
Journal Year:
2025,
Volume and Issue:
7(1), P. 7 - 7
Published: Jan. 15, 2025
The
human
microbiome,
a
complex
ecosystem
of
microorganisms
residing
in
and
on
the
body,
plays
pivotal
role
regulation
wide
range
physiological
processes,
including
digestion,
immune
responses,
metabolic
functions.
In
recent
years,
rapidly
growing
field
microbiome-driven
therapeutics
has
garnered
significant
attention
owing
to
its
potential
revolutionize
healthcare.
This
review
explores
evolving
landscape
microbiome-based
therapies,
with
particular
focus
gut
microbiome
implications
for
both
health
precision
medicine.
We
highlight
advances
understanding
how
microbial
communities
influence
disease
pathogenesis
treatment
outcomes,
spanning
conditions
such
as
inflammatory
bowel
(IBD),
disorders,
neurological
diseases,
even
cancer.
article
also
discusses
emerging
therapeutic
strategies,
probiotics,
prebiotics,
fecal
microbiota
transplantation
(FMT),
microbial-based
drugs,
well
challenges
associated
their
clinical
implementation.
Additionally,
we
examined
integration
profiling
metagenomic
data
is
advancing
medicine,
paving
way
personalized
effective
treatments.
serves
comprehensive
resource
that
synthesizes
current
knowledge,
identifies
key
gaps
research,
offers
insights
into
future
direction
therapeutics,
thus
providing
valuable
framework
clinicians,
researchers,
policymakers
seeking
harness
microbiomes
advance
healthcare
solutions.
Foods,
Journal Year:
2025,
Volume and Issue:
14(3), P. 495 - 495
Published: Feb. 4, 2025
Lactic
acid
bacteria
(LAB)
constitute
a
heterogeneous
group
of
isolated
from
fermented
foods,
animals,
plants,
and
mammalian
guts,
with
many
health-promoting
properties.
Probiotics
antagonistic
properties
against
human
pathogens
foodborne
have
garnered
significant
attention
the
scientific
fraternity.
A
dedicated
review
focusing
on
plant-derived
probiotic
their
has
not
been
comprehensively
reviewed.
Thus,
this
aimed
at
providing
an
overview
LAB
isolates
derived
several
unconventional
sources
such
as
fruits,
seeds,
fruit
pulp,
leaves,
roots,
vegetables,
grasses,
flowers
antibacterial,
antifungal,
antiviral
This
paper
reviewed
antimicrobial
different
genera,
Lactobacillus,
Leuconostoc,
Weissella,
Enterococcus,
Pediococcus,
Bacillus,
Fructobacillus,
postbiotics,
paraprobiotics.
Several
important
mechanisms,
including
secretion
bacteriocins,
bacteriocin-like
substances,
reuterin,
organic
acids
(lactic
acetic),
peptides,
exopolysaccharides,
hydrogen
peroxide,
attributed
to
actions
pathogens.
However,
precise
mode
action
is
poorly
understood;
hence,
further
research
should
be
conducted
reveal
detailed
mechanisms.
Finally,
discusses
summary
future
implications.
Given
significance,
compounds
can
potentially
exploited
in
food
preservation
safety
or
for
medicinal
applications
after
evaluating
safety.
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(3), P. 566 - 566
Published: March 2, 2025
The
global
nutraceutical
industry
is
experiencing
a
paradigm
shift,
driven
by
an
increasing
demand
for
functional
foods
and
dietary
supplements
that
address
malnutrition
chronic
diseases
such
as
obesity,
diabetes,
cardiovascular
conditions,
cancer.
Traditional
plant-
animal-derived
nutraceuticals
face
limitations
in
scalability,
cost,
environmental
impact,
paving
the
way
microbial
biotechnology
sustainable
alternative.
Microbial
cells
act
bio-factories,
converting
nutrients
like
glucose
amino
acids
into
valuable
products
polyunsaturated
fatty
(PUFAs),
peptides,
other
bioactive
compounds.
By
harnessing
their
natural
metabolic
capabilities,
microorganisms
efficiently
synthesize
these
compounds,
making
production
effective
approach
development.
This
review
explores
transformative
role
of
platforms
nutraceuticals,
emphasizing
advanced
fermentation
techniques,
synthetic
biology,
engineering.
It
addresses
challenges
optimizing
strains,
ensuring
product
quality,
scaling
while
navigating
regulatory
frameworks.
Furthermore,
highlights
cutting-edge
technologies
CRISPR/Cas9
genome
editing,
adaptive
evolution
strain
enhancement,
bioreactor
innovations
to
enhance
yield
efficiency.
With
focus
on
sustainability
precision,
positioned
game-changer
industry,
offering
eco-friendly
scalable
solutions
meet
health
needs.
integration
omics
exploration
novel
sources
hold
potential
revolutionize
this
field,
aligning
with
growing
consumer
innovative
products.
Foods,
Journal Year:
2024,
Volume and Issue:
13(23), P. 3886 - 3886
Published: Dec. 1, 2024
Foodborne
pathogens
are
microorganisms
that
cause
illness
through
contamination,
presenting
significant
risks
to
public
health
and
food
safety.
This
review
explores
the
metabolites
produced
by
these
pathogens,
including
toxins
secondary
metabolites,
their
implications
for
human
health,
particularly
concerning
cancer
risk.
We
examine
various
such
as
Salmonella
sp.,
Campylobacter
Escherichia
coli,
Listeria
monocytogenes,
detailing
specific
of
concern
carcinogenic
mechanisms.
study
discusses
analytical
techniques
detecting
chromatography,
spectrometry,
immunoassays,
along
with
challenges
associated
detection.
covers
effective
control
strategies,
processing
techniques,
sanitation
practices,
regulatory
measures,
emerging
technologies
in
pathogen
control.
manuscript
considers
broader
highlighting
importance
robust
policies,
awareness,
education.
identifies
research
gaps
innovative
approaches,
recommending
advancements
detection
methods,
preventive
policy
improvements
better
manage
foodborne
metabolites.
