Bacteriocins: potentials and prospects in health and agrifood systems

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(5)

Published: April 25, 2024

Abstract Bacteriocins are highly diverse, abundant, and heterogeneous antimicrobial peptides that ribosomally synthesized by bacteria archaea. Since their discovery about a century ago, there has been growing interest in bacteriocin research applications. This is mainly due to high properties, narrow or broad spectrum of activity, specificity, low cytotoxicity, stability. Though initially used improve food quality safety, bacteriocins now globally exploited for innovative applications human, animal, systems as sustainable alternatives antibiotics. have the potential beneficially modulate microbiota, providing viable microbiome-based solutions treatment, management, non-invasive bio-diagnosis infectious non-infectious diseases. The use holds great promise modulation microbiomes, packaging, bio-sanitizers antibiofilm, pre/post-harvest biocontrol, functional food, growth promotion, aquaculture. can undoubtedly security, globally. review highlights current trends research, especially increasing outputs funding, which we believe may proportionate soaring global bacteriocins. cutting-edge technologies, such bioengineering, further enhance exploitation systems.

Language: Английский

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Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

Population aging has become a primary global public health issue, and the prevention of age-associated diseases prolonging healthy life expectancies are particular importance. Gut microbiota emerged as novel target in various host physiological disorders including aging. Comprehensive understanding on changes gut during aging, characteristics centenarians, can provide us possibility to achieving or intervene pathological through microbiota-directed strategies. This review aims summarize associated with explore potential biomarkers address microbiota-associated mechanisms focusing intestinal barrier immune status. By summarizing existing effective dietary strategies interventions, probability developing diet targeting future is provided. focused three key notions: Firstly, new for regulating status lifespan, its closely related age. Thus, we summarized aging-associated features at levels genus/species important metabolites comparing differences among elderly people younger people. Secondly, exploring discussing using regime/components targeted aging-related promote human lifespan. Thirdly, intervention effectively improve imbalance such probiotics, prebiotics, postbiotics, but their effects vary among.

Language: Английский

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Recent Advances in the Understanding of Stress Resistance Mechanisms in Probiotics: Relevance for the Design of Functional Food Systems

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown

Published: June 3, 2024

Abstract In recent years, more and scientific community, food producers, industry show increased interest in functional foods containing probiotics, which is a big challenge. The consumption of probiotics the context balanced diet through or intake pharmaceutical preparations has proven to contribute improvement human health, even contributing prevention diseases. order for be considered suitable consumption, they must contain minimum concentration viable cells, namely, at least 10 7 colony forming units beneficial microbes per gram. Ensuring viability bacterial cells until moment overriding priority probiotic manufacturers. Probiotic bacteria are subject stress conditions not only during manufacturing but also gastrointestinal passage, limit compromise their functionality. This paper first examines all stressful faced by production stages related present bioreactor fermentation drying processes as well factors matrix storage. situations microorganisms transit especially stomach intestinal residence analyzed. understand adaptation mechanisms stress, intrinsic adaptive identified strains response acid bile addition, strategies multiple tolerance lactic directions dealing with accumulation metabolites, use protectants, regulation technological parameters examined. Finally, definition postbiotics, inanimate and/or components conferring health benefits, introduced. Postbiotics include cell lysates, enzymes, wall fragments derived from may represent an alternative when do tolerate conditions.

Language: Английский

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Bridging gap in the treatment of Alzheimer’s disease via postbiotics: Current practices and future prospects

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102689 - 102689

Published: Feb. 1, 2025

Language: Английский

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The potential of postbiotics as a novel approach in food packaging and biopreservation: a systematic review of the latest developments

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(33), P. 12524 - 12554

Published: Sept. 5, 2023

AbstractMetabolic by-products are part of the so-called postbiotics probiotics and other beneficial microorganisms, particularly lactic acid bacteria, which have gained popularity as a feasible alternative to improving food quality safety. Postbiotics in dry liquid forms can be easily integrated into formulations packaging materials, exhibiting antimicrobial antioxidant effects owing presence multiple antimicrobials, such organic acids, bacteriocins, exopolysaccharides bioactive peptides. thus control growth pathogens spoilage thereby extending shelf life products. Because their ability manufactured without requiring extensive processing, regarded safer more sustainable synthetic preservatives, negative environmental consequences. Additionally, manufacturers readily adopt significant modifications. This systematic review provides an in-depth analysis studies on use biopreservation wide range The evaluates discusses types preparation modification techniques, methods usage dairy products, meat, poultry, seafood, fruits, vegetables, bread, egg, safety.Keywords: Cell-free supernatantlactic bacteriapostbiotics challengesfood packagingyeast postbioticsparaprobiotics Author contributionsHoushmand Sharafi, Elahe Divsalar Zeinab Rezaei: Writing - Original Draft, Investigation; Shao-Quan Liu: Review & Editing; Mehran Moradi: Conceptualization, Editing, Project administration, Supervision.Disclosure statementNo potential conflict interest was reported by author(s).Additional informationFundingThe authors wish extend sincere gratitude Urmia University for providing necessary funding carry out this research.

Language: Английский

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Postbiotic Fractions of Probiotics Lactobacillus plantarum 299v and Lactobacillus rhamnosus GG Show Immune-Modulating Effects

Cells, Journal Year: 2023, Volume and Issue: 12(21), P. 2538 - 2538

Published: Oct. 28, 2023

Probiotic bacteria belonging to Lactobacillus spp. are important producers of bioactive molecules, known as postbiotics, that play essential roles in the immunological support intestinal mucosa. In this study, system co-culture epithelial cells with macrophage vitro was used study potential effect postbiotic fractions L. rhamonosus and plantarum on modulation immune response induced by pro-inflammatory stimuli. This study’s results revealed presence probiotic bacterial components mucosal surface early late stage inflammatory conditions is based cellular interactions control inflammation consequent damage epithelium. our studies, heat killed their extracted proteins showed a beneficial controlling inflammation, regardless strain tested, consequently protecting barrier damage. conclusion, presented emphasize rhamnosus may significant role regulation LPS-mediated cytotoxic activity cells. The strains suppress effectively activating anti-inflammatory cytokine IL-10 modulating IL-18-related response.

Language: Английский

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Taming neuroinflammation in Alzheimer's disease: The protective role of phytochemicals through the gut−brain axis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 178, P. 117277 - 117277

Published: Aug. 9, 2024

Language: Английский

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COVID-19 influenced gut dysbiosis, post-acute sequelae, immune regulation, and therapeutic regimens

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: May 28, 2024

The novel coronavirus disease 2019 (COVID-19) pandemic outbreak caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has garnered unprecedented global attention. It over 2.47 million deaths through various syndromes such as distress, hypercoagulability, and multiple organ failure. viral invasion proceeds the ACE2 receptor, expressed in cell types, some patients serious damage to tissues, organs, immune cells, microbes that colonize gastrointestinal tract (GIT). Some who survived SARS-CoV-2 infection have developed months of persistent long-COVID-19 symptoms or post-acute sequelae COVID-19 (PASC). Diagnosis these revealed biological effects, none which are mutually exclusive. However, severity also depends on numerous comorbidities obesity, age, diabetes, hypertension care must be taken with respect other morbidities, host immunity. Gut microbiota relation immunopathology is considered evolve progression via mechanisms biochemical metabolism, exacerbation inflammation, intestinal mucosal secretion, cytokine storm, immunity regulation. Therefore, modulation gut microbiome equilibrium food supplements probiotics remains a hot topic current research debate. In this review, we discuss complications physio-pathological effects infection, GIT response, therapeutic pharmacological strategies. We summarize targets probiotics, their limitations, efficacy preclinical clinical drugs effectively inhibit spread SARS-CoV-2.

Language: Английский

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Potential of postbiotics for the treatment of metabolic disorders

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(4), P. 103921 - 103921

Published: Feb. 20, 2024

Language: Английский

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Effect of Synbiotic and Postbiotic Supplements on Dental Caries and Periodontal Diseases—A Comprehensive Review

International Journal of Environmental Research and Public Health, Journal Year: 2025, Volume and Issue: 22(1), P. 72 - 72

Published: Jan. 8, 2025

Caries and periodontitis affect a significant part of the global population. Regular oral hygiene, sugar restriction, fluoride exposure are main avenues for maintenance health, but adjunctive use prebiotics probiotic bacteria has gained attention over past decades. The microbial clinical effects these biological interventions have been thoroughly covered in systematic reviews. However, combination probiotics (synbiotics) may boost benefits, postbiotics, being inanimate microorganisms, can, when added to hygiene products, offer sustainable option. aim this narrative review was summarize trials on synbiotics postbiotics prevention management dental caries, gingivitis, periodontitis. We searched two databases (PubMed Google Scholar) relevant literature, we identified 17 papers, five caries 12 with periodontal endpoints. found emerging evidence low certainty that lozenges/tablets containing or could reduce incidence preschool schoolchildren comparison standard preventive care. effect adult patients plaque-induced gingivitis less consistent. For adults periodontitis, synbiotic postbiotic products seemed enhance outcome conventional scaling root planning. In conclusion, both non-communicable diseases, closely associated an unbalanced biofilm, application modulators, including display promising beneficial warrant further research.

Language: Английский

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