Antibiotics-free compounds for managing carbapenem-resistant bacteria; a narrative review DOI Creative Commons

Aref Shariati,

Milad Kashi,

Zahra Chegini

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 17, 2024

Carbapenem-resistant (CR) Gram-negative bacteria have become a significant public health problem in the last decade. In recent years, prevalence of CR has increased. The resistance to carbapenems could result from different mechanisms such as loss porin, penicillin-binding protein alteration, carbapenemase, efflux pump, and biofilm community. Additionally, genetic variations like insertion, deletion, mutation, post-transcriptional modification corresponding coding genes decrease susceptibility carbapenems. this regard, scientists are looking for new approaches inhibit bacteria. Using bacteriophages, natural products, nanoparticles, disulfiram, N-acetylcysteine, antimicrobial peptides showed promising inhibitory effects against mentioned compounds destroy community them combination with conventional antibiotics increases efficacy antibiotics, decreases their dosage toxicity, resensitizes antibiotics. Therefore, present review article, we discussed aspects non-antibiotic managing inhibiting various methods procedures used an alternative these

Language: Английский

Antibiotics-free compounds for managing carbapenem-resistant bacteria; a narrative review DOI Creative Commons

Aref Shariati,

Milad Kashi,

Zahra Chegini

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 17, 2024

Carbapenem-resistant (CR) Gram-negative bacteria have become a significant public health problem in the last decade. In recent years, prevalence of CR has increased. The resistance to carbapenems could result from different mechanisms such as loss porin, penicillin-binding protein alteration, carbapenemase, efflux pump, and biofilm community. Additionally, genetic variations like insertion, deletion, mutation, post-transcriptional modification corresponding coding genes decrease susceptibility carbapenems. this regard, scientists are looking for new approaches inhibit bacteria. Using bacteriophages, natural products, nanoparticles, disulfiram, N-acetylcysteine, antimicrobial peptides showed promising inhibitory effects against mentioned compounds destroy community them combination with conventional antibiotics increases efficacy antibiotics, decreases their dosage toxicity, resensitizes antibiotics. Therefore, present review article, we discussed aspects non-antibiotic managing inhibiting various methods procedures used an alternative these

Language: Английский

Citations

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