Predicting superagers: a machine learning approach utilizing gut microbiome features DOI Creative Commons
Ha Eun Kim, Bori R. Kim,

Sang Hi Hong

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Sept. 9, 2024

Cognitive decline is often considered an inevitable aspect of aging; however, recent research has identified a subset older adults known as "superagers" who maintain cognitive abilities comparable to those younger individuals. Investigating the neurobiological characteristics associated with superior function in superagers essential for understanding "successful aging." Evidence suggests that gut microbiome plays key role brain function, forming bidirectional communication network microbiome-gut-brain axis. Alterations have been linked aging markers such oxidative stress and inflammation. This study aims investigate unique patterns develop machine learning-based predictive models differentiate from typical agers.

Language: Английский

Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer’s Disease DOI Open Access
Mona Abdelhamid, Scott Counts, Chunyu Zhou

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 558 - 558

Published: Jan. 31, 2025

Alzheimer’s disease (AD) is the most common form of dementia and characterized by memory impairment that significantly interferes with daily life. Therapeutic options for AD substantively modify progression remain a critical unmet need. In this regard, gut microbiota crucial in maintaining human health regulating metabolism immune responses, increasing evidence suggests probiotics, particularly beneficial bacteria, can enhance cognitive functions. Recent studies have highlighted positive effects Bifidobacterium breve MCC1274 (B. MCC1274) on individuals mild (MCI) schizophrenia. Additionally, oral supplementation B. has been shown to effectively prevent decline AppNL–G–F mice. relation pathology, found reduce amyloid-β (Aβ) accumulation tau phosphorylation both wild-type (WT) It also decreases microglial activation increases levels synaptic proteins. review, we examine AD, exploring potential mechanisms action how probiotic strain may aid preventing or treating disease. Furthermore, discuss broader implications improving overall host provide insights into future research directions promising therapy.

Language: Английский

Citations

2
Advances in understanding dietary fiber: Classification, structural characterization, modification, and gut microbiome interactions DOI Creative Commons
Yiming Feng, Qing Jin,

Xuanbo Liu

et al.

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 1, 2025

Abstract Gut microbiota and their metabolites profoundly impact host physiology. Targeted modulation of gut has been a long‐term interest in the scientific community. Numerous studies have investigated feasibility utilizing dietary fibers (DFs) to modulate promote production health‐beneficial bacterial metabolites. However, complexity fiber structures, composition, dynamic interactions hindered precise prediction DF on microbiome. We address this issue with new perspective, focusing inherent chemical structural DFs interaction microbiota. The was thoroughly elaborated, encompassing fibers’ molecular polymorphism, mesoscopic porosity, particle size. Advanced characterization techniques investigate properties were discussed. Additionally, we examined between Finally, summarized processing modify structures for improving fermentability by structure fibers, such as crystallinity, degree branching, pore wettability, significantly impacts These differences also substantially affect fiber's capability composition Conventional approaches are not capable investigating complex influences microbiome; therefore, it is essence involve advanced material artificial intelligence unveil more comprehensive information topic.

Language: Английский

Citations

0
The Legalome: Microbiology, Omics and Criminal Justice DOI Creative Commons
Alan C. Logan, Pragya Mishra, Susan L. Prescott

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(3)

Published: March 1, 2025

ABSTRACT Advances in neuromicrobiology and related omics technologies have reinforced the idea that unseen microbes play critical roles human cognition behaviour. Included this research is evidence indicating gut microbes, through direct indirect pathways, can influence aggression, anger, irritability antisocial Moreover, manufacture chemicals are known to compromise cognition. For example, recent court decisions United States Europe acknowledge produce high levels of ethanol, without consumption alcohol by defendants. The dismissal driving while intoxicated charges these cases—so‐called auto‐brewery syndrome—highlights way which microbiome knowledge will enhance precision, objectivity fairness our legal systems. Here opinion essay, we introduce concept ‘legalome’—the application science forensic psychiatry criminal law. We argue rapid pace microbial discoveries, including those challenge ideas free moral responsibility, necessitate a reconsideration traditional doctrines justifications retributive punishment. implications extend beyond courtroom, challenging us reconsider how environmental factors—from diet socioeconomic conditions—might shape preventative rehabilitative efforts their effects on microbiome.

Language: Английский

Citations

0
The Legalome: Nutritional Psychology and Microbiome Sciences at the Intersection of Criminal Justice, Mens Rea, and Mitigation DOI
Susan L. Prescott, Alan C. Logan

Criminal Justice and Behavior, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Recent studies have linked ultra-processed foods with neuropsychiatric disorders, and behaviors of relevance to the criminal justice system. This nutritional epidemiology has been bolstered by mechanistic bench science, human intervention trials, addiction advances in microbiome research. Here, we examine this burgeoning research through lens diminished capacity intent. We use recent legal decisions related auto-brewery syndrome as a way illustrate how intersecting diet gut science is already finding its courtrooms. The legalome—microbiome omics applied forensic psychology—is emerging an important consideration for experts within field behavior. It our contention that are merely prelude ways which combination microbiology psychology will challenge basic assumptions free mens rea.

Language: Английский

Citations

3
Probiotic Potential of Lactic Acid Bacteria with Antioxidant Properties in Modulating Health: Mechanisms, Applications, and Future Directions DOI
Yuan Gao, Qianyi Liang,

Junqi Sun

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106181 - 106181

Published: Feb. 1, 2025

Language: Английский

Citations

0
The Impact of Microbiota on Neurological Disorders: Mechanisms and Therapeutic Implications DOI Open Access
Giuseppe Merra,

Giada La Placa,

Marcello Covino

et al.

OBM Neurobiology, Journal Year: 2025, Volume and Issue: 09(01), P. 1 - 12

Published: Feb. 28, 2025

Interactions in the gut-brain crosstalk have led to development of an entirely new concept: "microbiota-gut-brain axis". Microbiota has gained considerable attention relation disorders a more neurological nature, such as neurodevelopmental and neuropsychiatric illnesses like autism spectrum disorder, anxiety, mood disorders. This review aims summarize recent trends insights into role consequences gut microbiota brain health pediatric Dysbiosis may be associated with increased risk diseases that lead different disruptions conditions, including mental issues. During dysbiosis, neuropsychological stress hormones usually affect oxytocin GABA neurons are significantly reduced. Current studies report major depression, cognitive dysfunction closely dysbiosis. In last few years, handful clinical emerged, illustrating potential for bidirectional relationship interactions humans. Perhaps some most crucial investigations demonstrating overlapping relationships human axis come from trials focusing on modulating noting significant correlates. A field is emerging gene-editing technology could represent tool improve microbial characteristics. approach particularly relevant neurodegenerative brain-gut linked loss species and/or high pathobiont load.

Language: Английский

Citations

0
AGING THROUGH THE LENS OF THE GUT MICROBIOME: CHALLENGES AND THERAPEUTIC OPPORTUNITIES DOI Creative Commons

N.V. Kanimozhi,

M. Sukumar

Archives of Gerontology and Geriatrics Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100142 - 100142

Published: March 1, 2025

Language: Английский

Citations

0
Lactobacillus rhamnosus: An Emerging Probiotic with Therapeutic Potential for Depression DOI Creative Commons
Jing Feng,

Qiuyu Cen,

Yi Cui

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107541 - 107541

Published: Dec. 1, 2024

Depression, a complex psychological disorder, involves multiple biological pathways in its pathogenesis. In recent years, the gut-brain axis theory has provided novel insights into pathogenesis of depression, particularly crucial role gut microbiota mood regulation. While there remains no universal consensus on most efficacious strains for depression treatment, Lactobacillus rhamnosus risen to prominence within realm probiotics potential positively modulate depressive symptoms. This review preliminarily explores clinical significance treatment and summarizes mechanisms by which treats including regulation microbiota, alterations gene expression, improvement intestinal barrier function, maintenance neurotransmitter balance, suppression inflammatory responses, modulation immune system, coping with oxidative stress, optimization metabolic processes. Future research needs further explore these combine them results optimize plans provide more effective options patients depression.

Language: Английский

Citations

1
Predicting superagers: a machine learning approach utilizing gut microbiome features DOI Creative Commons
Ha Eun Kim, Bori R. Kim,

Sang Hi Hong

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Sept. 9, 2024

Cognitive decline is often considered an inevitable aspect of aging; however, recent research has identified a subset older adults known as "superagers" who maintain cognitive abilities comparable to those younger individuals. Investigating the neurobiological characteristics associated with superior function in superagers essential for understanding "successful aging." Evidence suggests that gut microbiome plays key role brain function, forming bidirectional communication network microbiome-gut-brain axis. Alterations have been linked aging markers such oxidative stress and inflammation. This study aims investigate unique patterns develop machine learning-based predictive models differentiate from typical agers.

Language: Английский

Citations

0