Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases DOI Open Access
Sachchida Nand, Divya Mishra, Payal Singh

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 137, P. 111377 - 111377

Published: Feb. 16, 2021

Neurodegenerative diseases (NDs) represent a common neurological pathology that determines progressive deterioration of the brain or nervous system. For treating NDs, comprehensive and alternative medicines have attracted scientific researchers' attention recently. Edible mushrooms are essential for preventing several age-based neuronal dysfunctions such as Parkinson's Alzheimer's diseases. Mushroom Grifola frondosa, Lignosus rhinocerotis, Hericium erinaceus, may improve cognitive functions. It has also been reported edible (basidiocarps/mycelia extracts isolated bioactive compounds) reduce beta-amyloid-induced neurotoxicity. Medicinal being used novel natural compounds help modulate immune responses possess anti-cancer, anti-microbial, anti-oxidant properties. Compounds polyphenols, terpenoids, alkaloids, sesquiterpenes, polysaccharides, metal chelating agents validated in different ND treatments. This review aims to assess mushrooms' role their biomolecules utilization kinds NDs. The action mechanisms, presented here, including reducing oxidative stress, neuroinflammation, modulation acetylcholinesterase activity, protecting neurons stimulation, regulating neurotrophins synthesis. We provide background about neurodegenerative in-silico techniques drug research. High costs associated with experiments current ethical law imply efficient alternatives limited cost value. In silico approaches an method low successfully implemented cure disorders recent days. describe applications computational procedures molecular docking, virtual high-throughput screening, dynamic (MD) simulation, quantum-mechanical methods design. They were against various targets

Language: Английский

RETRACTED ARTICLE: Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours DOI Creative Commons
Fei Xu, Lixin Na, Yanfei Li

et al.

Cell & Bioscience, Journal Year: 2020, Volume and Issue: 10(1)

Published: April 1, 2020

Abstract The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of signal transduction and biological processes such as cell proliferation, apoptosis, metabolism angiogenesis. Compared with those other pathways, components PI3K/AKT/mTOR are complicated. regulatory mechanisms functions many human diseases, including ischaemic brain injury, neurodegenerative tumours. inhibitors include single-component dual inhibitors. Numerous PI3K have exhibited good results preclinical studies, some been clinically tested haematologic malignancies solid In this review, we briefly summarize research on discuss structural composition, activation, communication processes, pathogenesis diseases

Language: Английский

Citations

485
ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer DOI Creative Commons
Reiko Sugiura, Ryosuke Satoh, Teruaki Takasaki

et al.

Cells, Journal Year: 2021, Volume and Issue: 10(10), P. 2509 - 2509

Published: Sept. 22, 2021

The RAF/MEK/ERK signaling pathway regulates diverse cellular processes as exemplified by cell proliferation, differentiation, motility, and survival. Activation of ERK1/2 generally promotes its deregulated activity is a hallmark many cancers. Therefore, components regulators the ERK are considered potential therapeutic targets for cancer, inhibitors this pathway, including some MEK BRAF inhibitors, already being used in clinic. Notably, kinases also have pro-apoptotic functions under certain conditions enhanced can cause tumor death. Although repertoire compounds which mediate activation apoptosis expanding, various anti-cancer induce while exerting their anti-proliferative effects, mechanisms underlying ERK1/2-mediated death still vague. Recent studies highlight importance dual-specificity phosphatases (DUSPs) determining pro- versus anti-apoptotic function cancer. In review, we will summarize recent major findings understanding role apoptosis, focusing on mediating ERK-dependent apoptosis. Studies that further define molecular these relevant to be essential harnessing developing effective cancer treatments.

Language: Английский

Citations

235
NF-κB-Mediated Neuroinflammation in Parkinson’s Disease and Potential Therapeutic Effect of Polyphenols DOI
Saumitra Sen Singh, Sachchida Nand, Hareram Birla

et al.

Neurotoxicity Research, Journal Year: 2019, Volume and Issue: 37(3), P. 491 - 507

Published: Dec. 10, 2019

Language: Английский

Citations

158
Mitochondrial Dysfunction: a Potential Therapeutic Target to Treat Alzheimer’s Disease DOI
Sachchida Nand, Charan Singh,

Arti Singh

et al.

Molecular Neurobiology, Journal Year: 2020, Volume and Issue: 57(7), P. 3075 - 3088

Published: May 27, 2020

Language: Английский

Citations

142
Recent developments in essentiality of trivalent chromium and toxicity of hexavalent chromium: Implications on human health and remediation strategies DOI

Aashna Monga,

Abhay B. Fulke,

Debjani Dasgupta

et al.

Journal of Hazardous Materials Advances, Journal Year: 2022, Volume and Issue: 7, P. 100113 - 100113

Published: June 17, 2022

Language: Английский

Citations

142
Microglia Mediated Neuroinflammation in Parkinson’s Disease DOI Creative Commons
Sevim Işık, Kiyak Bercem Yeman, Rumeysa Akbayir

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(7), P. 1012 - 1012

Published: March 25, 2023

Parkinson’s Disease (PD) is the second most common neurodegenerative disorder seen, especially in elderly. Tremor, shaking, movement problems, and difficulty with balance coordination are among hallmarks, dopaminergic neuronal loss substantia nigra pars compacta of brain aggregation intracellular protein α-synuclein pathological characterizations. Neuroinflammation has emerged as an involving mechanism at initiation development PD. It a complex network interactions comprising immune non-immune cells addition to mediators response. Microglia, resident macrophages CNS, take on leading role regulating neuroinflammation maintaining homeostasis. Under normal physiological conditions, they exist “homeostatic” but upon stimuli, switch “reactive state”. Pro-inflammatory (M1) anti-inflammatory (M2) phenotypes used classify microglial activity each phenotype having its own markers released mediators. When M1 microglia persistent, will contribute various inflammatory diseases, including such In this review, we focus mediated PD also signaling pathways, receptors, involved process, presenting studies that associate microglia-mediated inflammation A better understanding important seeking new therapies for possibly other diseases.

Language: Английский

Citations

120
The neuroprotective effects of glucagon-like peptide 1 in Alzheimer’s and Parkinson’s disease: An in-depth review DOI Creative Commons
Niklas Reich, Christian Hölscher

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Sept. 1, 2022

Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's disease (AD PD) that includes the highly controversial approval of Aβ-targeting antibody aducanumab AD. Hence, still an unmet need a neuroprotective drug in both AD PD. Type 2 diabetes risk factor Glucagon-like peptide 1 (GLP-1) hormone growth has shown effects preclinical studies, success GLP-1 mimetics phase II clinical trials PD raised new hope. are currently on market as treatments type diabetes. analogs safe, well tolerated, resistant to desensitization characterized clinic. Herein, we review existing evidence illustrate pathways induced following GLP-1R activation neurons, microglia astrocytes. The latter include synaptic protection, improvements cognition, learning motor function, amyloid pathology-ameliorating properties (Aβ, Tau, α-synuclein), suppression Ca

Language: Английский

Citations

116
Impairment of insulin signaling pathway PI3K/Akt/mTOR and insulin resistance induced AGEs on diabetes mellitus and neurodegenerative diseases: a perspective review DOI
Kanagavalli Ramasubbu,

V. Devi Rajeswari

Molecular and Cellular Biochemistry, Journal Year: 2022, Volume and Issue: 478(6), P. 1307 - 1324

Published: Oct. 29, 2022

Language: Английский

Citations

91
Targeting the PI3K/AKT/mTOR Signaling Pathway in the Treatment of Human Diseases: Current Status, Trends, and Solutions DOI

Jindi Huang,

Liye Chen,

Jiangxia Wu

et al.

Journal of Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 65(24), P. 16033 - 16061

Published: Dec. 12, 2022

The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is one the most important intracellular pathways involved in cell proliferation, growth, differentiation, and survival. Therefore, this route a prospective biological for treating various human diseases, such as tumors, neurodegenerative pulmonary fibrosis, diabetes. An increasing number clinical studies emphasize necessity developing novel molecules targeting PI3K/AKT/mTOR pathway. This review focuses on recent advances ATP-competitive inhibitors, allosteric covalent proteolysis-targeting chimeras against pathway, highlights possible solutions overcoming toxicities acquired drug resistance currently available drugs. We also provide recommendations future design development promising drugs

Language: Английский

Citations

76
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders DOI Creative Commons

Thian‐Sze Wong,

Guangzhi Li, Shiliang Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: May 3, 2023

Neuropsychiatric disorders are multifactorial with diverse aetiological factors. Identifying treatment targets is challenging because the diseases resulting from heterogeneous biological, genetic, and environmental Nevertheless, increasing understanding of G protein-coupled receptor (GPCR) opens a new possibility in drug discovery. Harnessing our knowledge molecular mechanisms structural information GPCRs will be advantageous for developing effective drugs. This review provides an overview role various neurodegenerative psychiatric diseases. Besides, we highlight emerging opportunities novel GPCR address recent progress development.

Language: Английский

Citations

64