Antimicrobial nanoparticles: current landscape and future challenges

RSC Pharmaceutics, Journal Year: 2024, Volume and Issue: 1(3), P. 388 - 402

Published: Jan. 1, 2024

Antimicrobial resistance poses a serious threat to global health, necessitating the exploration of innovative solutions.

Language: Английский

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Novel functionalized phenyl acetate derivatives of benzo [e]-bispyrone fused hybrids: Synthesis and biological activities

Results in Chemistry, Journal Year: 2023, Volume and Issue: 5, P. 100942 - 100942

Published: Jan. 1, 2023

Eighteen novel functionalized phenyl acetate derivatives of benzo[e]-bispyrone fused hybrids and their three precursors are developed in this study. The precursor acetic acid congeners (Y1, Y8, Y15) were created by combining acetone dicarboxylic resorcinol-based compounds. They utilized the preparation (Y2-Y7, Y9-Y14, Y16-Y21). Six vitro biological activities investigated for synthesized derivatives. First, reactive species-caging activity was tested against DPPH hydroxyl radicals. Second, cellular viability-terminating assayed using MTT-visual probing methodology six common cancerous cell lines. Third, fourth, fifth activities, collectively termed microbial-shedding potential, examined a microdilution broth aerobic pathogenic bacterial strains, four anaerobic two fungal respectively. Finally, blood sugar-dropping assessed related enzymes. Moreover, toxic effects twenty-one compounds one normal human line non-pathogenic strain. results showed that hybrids' methoxyphenyl (Y2, Y9, Y16) had greatest species-caging, bacterial-shooting, activities. In terms activity, fluorophenyl (Y4, Y11, Y18) demonstrated lines while causing least toxicity to line. Chlorophenyl highest pathogen-shedding on strains (Y5, Y12, Y19). with flourophenyl or chlorophenyl levels fungal-shooting exceeding reference. researchers concluded from these observations provided several biosafe scaffolds multiple selective

Language: Английский

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Harmful Free Radicals in Aging: A Narrative Review of Their Detrimental Effects on Health

Indian Journal of Clinical Biochemistry, Journal Year: 2023, Volume and Issue: 39(2), P. 154 - 167

Published: Aug. 1, 2023

Language: Английский

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Combretastatin A4-based coumarins: synthesis, anticancer, oxidative stress-relieving, anti-inflammatory, biosafety, and in silico analysis

Chemical Papers, Journal Year: 2024, Volume and Issue: 78(6), P. 3705 - 3720

Published: Feb. 18, 2024

Language: Английский

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6,7-Coumarin-heterocyclic hybrids: A comprehensive review of their natural sources, synthetic approaches, and bioactivity

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1303, P. 137601 - 137601

Published: Jan. 22, 2024

Language: Английский

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Coumarin hybrids for targeted therapies: A promising approach for potential drug candidates

Phytochemistry Letters, Journal Year: 2024, Volume and Issue: 60, P. 117 - 133

Published: Feb. 8, 2024

Language: Английский

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Biocompatible chlorocoumarins from harmful chlorophenols, their synthesis and biomedicinal evaluation

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1309, P. 138193 - 138193

Published: March 30, 2024

Language: Английский

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4-Chloroskimmetine-based derivatives as potential anticancer and antibacterial prospects: Their synthesis and in vitro inspections

Results in Chemistry, Journal Year: 2024, Volume and Issue: 7, P. 101511 - 101511

Published: Jan. 1, 2024

Cancer and bacterial infections are among the most high-interest health threats facing humanity. The growing resistance to current-found anticancer antibacterial drugs necessitates exploration of new, effective agents. To synthesize some them, 4-chloroskimmetine (4-CSM), with undefined biological effects, was used as a building block create thirteen its derived coumarins. This precursor Bargellini reaction were produce first coumarin, designated Y0. From which, twelve coumarins coded Y1-Y12 created by esterifying Y0 various halophenols using SOCl2-promoted reaction. FTIR, 1HNMR, 13CNMR spectra analyzed ascertain chemical framework Their potential function prospects evaluated against six cancer-derived populations employing preliminary MTT-facilitated methodology. These MCF-7, HeLa, SKG, AMN3, SK-OV-3, KYSE-30. On other hand, broth microdilution protocol followed specify activity high-infective aerobes. include Pseudomonas aeruginosa, Shigella dysenteriae, Haemophilus influenza, Klebsiella pneumonia, Escherichia coli, Salmonella typhi. results evaluation indicated that presence fluoride on off-side aromatic ring afforded potent activity, Y5 best. For second same findings true, but when halogen is chloride Y2 superior one. authors concluded 4-CSM, can be exploited bioactive activities. Also, considered promising structural templates for producing medications, respectively.

Language: Английский

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Coumarins from carcinogenic phenol: synthesis, characterization, in silico, biosafety, anticancer, antioxidant, and anti-inflammatory assessments

Chemical Papers, Journal Year: 2023, Volume and Issue: 78(1), P. 493 - 504

Published: Oct. 9, 2023

Language: Английский

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Emerging trends and future opportunities for coumarin-heterocycle conjugates as antibacterial agents

Results in Chemistry, Journal Year: 2023, Volume and Issue: 6, P. 101151 - 101151

Published: Oct. 5, 2023

Infectious diseases resulting from various strains of pathogenic bacteria are among the leading causes death and morbidity worldwide. The currently-available antibacterial medications developed natural or synthetic sources cornerstone bacterial infection intervention, but somehow mounting spread expansion multidrug-resistant harmful has become a major concern for medical-providing communities pharmaceutical-releasing companies. pervasiveness coumarin-based products in nature simplicity their lab chemical synthesis, addition to ability coumarin backbone communicate, may interact with DNA gyrase at B subunit hinder secondary structure by abolishing ATPase activity; thus, conjugates have potential act as agents. It is conceivable that conjugation nucleus other heterocyclic-based scaffolds present opportunities creation novel drugs. This presentation be based on fact several coumarin-heterocycle conjugates, including clorobiocin, coumermycin A1, novobiocin, already been used medical methods treatment infectious diseases. study explores, during period last 5 years, relationships between activity action. investigation also explored developing these into medicines.

Language: Английский

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