Current Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
31(32), P. 5178 - 5198
Published: Feb. 2, 2024
Cancer
is
a
complex
and
heterogeneous
malignant
disease.
Due
to
its
multifactorial
nature,
including
progressive
changes
in
genetic,
epigenetic,
transcript,
protein
levels,
conventional
therapeutics
fail
save
cancer
patients.
Evidence
indicates
that
dysregulation
of
microRNA
(miRNA)
expression
plays
crucial
role
tumorigenesis,
metastasis,
cell
proliferation,
differentiation,
metabolism,
signaling
pathways.
Moreover,
miRNAs
can
be
used
as
diagnostic
prognostic
markers
therapeutic
targets
cancer.
Berberine,
naturally
occurring
plant
alkaloid,
has
wide
spectrum
biological
activities
different
types
cancers.
Inhibition
migration,
invasion,
angiogenesis,
well
induction
cycle
arrest
apoptosis
cells,
reported
by
berberine.
Recent
studies
suggested
berberine
regulates
many
oncogenic
tumor
suppressor
implicated
phases
This
review
discussed
how
inhibits
growth
propagation
cells.
And
berberine-mediated
miRNA
regulation
the
landscape
transcripts
proteins
promote
or
suppress
progression.
Overall,
underlying
molecular
pathways
altered
influencing
pathophysiology
will
enhance
our
understanding
combat
malignancy.
Results in Chemistry,
Journal Year:
2024,
Volume and Issue:
7, P. 101511 - 101511
Published: Jan. 1, 2024
Cancer
and
bacterial
infections
are
among
the
most
high-interest
health
threats
facing
humanity.
The
growing
resistance
to
current-found
anticancer
antibacterial
drugs
necessitates
exploration
of
new,
effective
agents.
To
synthesize
some
them,
4-chloroskimmetine
(4-CSM),
with
undefined
biological
effects,
was
used
as
a
building
block
create
thirteen
its
derived
coumarins.
This
precursor
Bargellini
reaction
were
produce
first
coumarin,
designated
Y0.
From
which,
twelve
coumarins
coded
Y1-Y12
created
by
esterifying
Y0
various
halophenols
using
SOCl2-promoted
reaction.
FTIR,
1HNMR,
13CNMR
spectra
analyzed
ascertain
chemical
framework
Their
potential
function
prospects
evaluated
against
six
cancer-derived
populations
employing
preliminary
MTT-facilitated
methodology.
These
MCF-7,
HeLa,
SKG,
AMN3,
SK-OV-3,
KYSE-30.
On
other
hand,
broth
microdilution
protocol
followed
specify
activity
high-infective
aerobes.
include
Pseudomonas
aeruginosa,
Shigella
dysenteriae,
Haemophilus
influenza,
Klebsiella
pneumonia,
Escherichia
coli,
Salmonella
typhi.
results
evaluation
indicated
that
presence
fluoride
on
off-side
aromatic
ring
afforded
potent
activity,
Y5
best.
For
second
same
findings
true,
but
when
halogen
is
chloride
Y2
superior
one.
authors
concluded
4-CSM,
can
be
exploited
bioactive
activities.
Also,
considered
promising
structural
templates
for
producing
medications,
respectively.
Results in Chemistry,
Journal Year:
2023,
Volume and Issue:
6, P. 101151 - 101151
Published: Oct. 5, 2023
Infectious
diseases
resulting
from
various
strains
of
pathogenic
bacteria
are
among
the
leading
causes
death
and
morbidity
worldwide.
The
currently-available
antibacterial
medications
developed
natural
or
synthetic
sources
cornerstone
bacterial
infection
intervention,
but
somehow
mounting
spread
expansion
multidrug-resistant
harmful
has
become
a
major
concern
for
medical-providing
communities
pharmaceutical-releasing
companies.
pervasiveness
coumarin-based
products
in
nature
simplicity
their
lab
chemical
synthesis,
addition
to
ability
coumarin
backbone
communicate,
may
interact
with
DNA
gyrase
at
B
subunit
hinder
secondary
structure
by
abolishing
ATPase
activity;
thus,
conjugates
have
potential
act
as
agents.
It
is
conceivable
that
conjugation
nucleus
other
heterocyclic-based
scaffolds
present
opportunities
creation
novel
drugs.
This
presentation
be
based
on
fact
several
coumarin-heterocycle
conjugates,
including
clorobiocin,
coumermycin
A1,
novobiocin,
already
been
used
medical
methods
treatment
infectious
diseases.
study
explores,
during
period
last
5
years,
relationships
between
activity
action.
investigation
also
explored
developing
these
into
medicines.
