Combretastatin A4-based coumarins: synthesis, anticancer, oxidative stress-relieving, anti-inflammatory, biosafety, and in silico analysis

Chemical Papers, Journal Year: 2024, Volume and Issue: 78(6), P. 3705 - 3720

Published: Feb. 18, 2024

Language: Английский

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6,7-Coumarin-heterocyclic hybrids: A comprehensive review of their natural sources, synthetic approaches, and bioactivity

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1303, P. 137601 - 137601

Published: Jan. 22, 2024

Language: Английский

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Biocompatible chlorocoumarins from harmful chlorophenols, their synthesis and biomedicinal evaluation

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1309, P. 138193 - 138193

Published: March 30, 2024

Language: Английский

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4-Chloroskimmetine-based derivatives as potential anticancer and antibacterial prospects: Their synthesis and in vitro inspections

Results in Chemistry, Journal Year: 2024, Volume and Issue: 7, P. 101511 - 101511

Published: Jan. 1, 2024

Cancer and bacterial infections are among the most high-interest health threats facing humanity. The growing resistance to current-found anticancer antibacterial drugs necessitates exploration of new, effective agents. To synthesize some them, 4-chloroskimmetine (4-CSM), with undefined biological effects, was used as a building block create thirteen its derived coumarins. This precursor Bargellini reaction were produce first coumarin, designated Y0. From which, twelve coumarins coded Y1-Y12 created by esterifying Y0 various halophenols using SOCl2-promoted reaction. FTIR, 1HNMR, 13CNMR spectra analyzed ascertain chemical framework Their potential function prospects evaluated against six cancer-derived populations employing preliminary MTT-facilitated methodology. These MCF-7, HeLa, SKG, AMN3, SK-OV-3, KYSE-30. On other hand, broth microdilution protocol followed specify activity high-infective aerobes. include Pseudomonas aeruginosa, Shigella dysenteriae, Haemophilus influenza, Klebsiella pneumonia, Escherichia coli, Salmonella typhi. results evaluation indicated that presence fluoride on off-side aromatic ring afforded potent activity, Y5 best. For second same findings true, but when halogen is chloride Y2 superior one. authors concluded 4-CSM, can be exploited bioactive activities. Also, considered promising structural templates for producing medications, respectively.

Language: Английский

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Food-Derived Micronutrients as Alleviators of Age-Related Dysfunction: A Dive into Their Effects and Cellular Mechanisms

Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

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Emerging trends and future opportunities for coumarin-heterocycle conjugates as antibacterial agents

Results in Chemistry, Journal Year: 2023, Volume and Issue: 6, P. 101151 - 101151

Published: Oct. 5, 2023

Infectious diseases resulting from various strains of pathogenic bacteria are among the leading causes death and morbidity worldwide. The currently-available antibacterial medications developed natural or synthetic sources cornerstone bacterial infection intervention, but somehow mounting spread expansion multidrug-resistant harmful has become a major concern for medical-providing communities pharmaceutical-releasing companies. pervasiveness coumarin-based products in nature simplicity their lab chemical synthesis, addition to ability coumarin backbone communicate, may interact with DNA gyrase at B subunit hinder secondary structure by abolishing ATPase activity; thus, conjugates have potential act as agents. It is conceivable that conjugation nucleus other heterocyclic-based scaffolds present opportunities creation novel drugs. This presentation be based on fact several coumarin-heterocycle conjugates, including clorobiocin, coumermycin A1, novobiocin, already been used medical methods treatment infectious diseases. study explores, during period last 5 years, relationships between activity action. investigation also explored developing these into medicines.

Language: Английский

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Coumarins derived from natural methoxystilbene as oxidative stress-related disease alleviators: Synthesis and in vitro-in silico study

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1302, P. 137471 - 137471

Published: Dec. 31, 2023

Language: Английский

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Triple coumarin-based 5-fluorouracil prodrugs, their synthesis, characterization, and release kinetics

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1301, P. 137415 - 137415

Published: Dec. 26, 2023

Language: Английский

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Novel coumarins from green sweet bell pepper seeds: Their isolation, characterization, oxidative stress-mitigating, anticancer, anti-inflammatory, and antidiabetic properties

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1312, P. 138629 - 138629

Published: May 16, 2024

Language: Английский

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Natural linear coumarin-heterocyclic conjugates: A review of their roles in phytotherapy

Fitoterapia, Journal Year: 2024, Volume and Issue: 175, P. 105929 - 105929

Published: March 27, 2024

Language: Английский

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