Nanozymes as a novel solution for oxidative stress reduction and nitrogen compound removal in aquatic systems: a study on common carp (Cyprinus carpio) DOI
Ammar Abdulrazzaq Tawfeeq, Th. T. Mohammed, Bilal J.M. Aldahham

et al.

Fish Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: 51(2)

Published: April 1, 2025

Language: Английский

Insights into the Therapeutic Targets and Molecular Mechanisms of Eruca sativa Against Colorectal Cancer: An Integrated Approach Combining Network Pharmacology, Molecular Docking and Dynamics Simulation DOI Creative Commons

Humera Banu,

Eyad Al-Shammari,

Syed Shahanawaz

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 453 - 453

Published: March 24, 2025

Background/Objectives: This study presents a novel and comprehensive investigation into the anti-colorectal cancer (CRC) effects underlying mechanisms of Eruca sativa (E. sativa) using an integrated approach combining network pharmacology, molecular docking dynamics simulation. Methods: Using approach, six bioactive compounds 40 potential targets were identified. A compound–target was constructed, enrichment analysis performed to explore key pathways influenced by E. sativa. Molecular used evaluate binding interactions between identified CRC-related (AKT1, PGR, MMP9, PTGS2). Furthermore, simulation utilized confirm stability reliability these interactions. Results: The found that exhibits strong anticancer potential, particularly through major such as β-ionone, 1-octanol, isorhamnetin, 2-hexenal, propionic acid, quercetin. revealed favorable CRC targets, with quercetin isorhamnetin showing highest affinities. Additionally, simulations validated interactions, reinforcing their therapeutic relevance. Conclusions: provides valuable insights pharmacological against CRC, highlighting its natural agent. These findings pave way for future clinical studies validate efficacy safety compounds, potentially contributing development novel, plant-based strategies treatment.

Language: Английский

Citations

1
Exploring the antibiotic potential of copper carbonate nanoparticles, wound healing, and glucose-lowering effects in diabetic albino mice DOI
Muhammad Waseem Aslam,

Sabeen Sabri,

Ali Umar

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 754, P. 151527 - 151527

Published: Feb. 22, 2025

Language: Английский

Citations

0
Microbiological and physiological impacts of coconut oil microcapsule powder supplementation on Liza ramada DOI
Mohammed F. El Basuini,

Maha Yahia,

Abdelaziz M. El‐Hais

et al.

Aquaculture, Journal Year: 2025, Volume and Issue: 602, P. 742369 - 742369

Published: Feb. 28, 2025

Language: Английский

Citations

0
Nanozymes as a novel solution for oxidative stress reduction and nitrogen compound removal in aquatic systems: a study on common carp (Cyprinus carpio) DOI
Ammar Abdulrazzaq Tawfeeq, Th. T. Mohammed, Bilal J.M. Aldahham

et al.

Fish Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: 51(2)

Published: April 1, 2025

Language: Английский

Citations

0