Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(4)

Published: April 1, 2025

ABSTRACT Colorectal cancer (CRC) is a leading cause of cancer‐related mortality globally, with increasing incidence presenting significant treatment challenges. Traditional nontargeted therapies often result in high toxicity and limited efficacy, underscoring the need for improved modalities. This review highlights recent advancements drug delivery systems to enhance therapeutic outcomes CRC. We examine innovative strategies, including computer‐assisted pharmaceutical formulation, sustained‐release matrices, prodrugs, as well targeted mechanisms such exosomes, liposomes, hydrogels, antibody‐drug conjugates, stimuli‐responsive systems. These methodologies offer biodistribution, enhanced targeting cells, reduced off‐target effects, promising better clinical outcomes. Additionally, we discuss development novel formulations designed optimize agents advanced Ongoing trials investigating these signify shift toward more effective patient options. While challenges remain application therapies, continued research offers avenues improving study aims inform future strategies managing this aggressive disease, ultimately enhancing survival rates quality life affected individuals.

Language: Английский