World Neurosurgery X,
Journal Year:
2024,
Volume and Issue:
23, P. 100391 - 100391
Published: May 1, 2024
Brain
metastases
(BMs)
most
frequently
originate
from
the
primary
tumors
of
lung
and
breast.
Survival
in
patients
with
BM
can
improve
if
they
are
detected
early.
No
studies
attempt
to
consider
all
potential
surgical
predictive
factors
together
by
including
clinical,
radiological
variables
for
their
recognition.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 4, 2025
Numerous
studies
have
investigated
the
molecular
mechanisms
and
signalling
pathways
underlying
cancer
metastasis,
as
there
is
still
no
effective
treatment
for
this
terminal
stage
of
disease.
However,
exact
processes
that
enable
primary
cells
to
acquire
a
metastatic
phenotype
remain
unclear.
Increasing
attention
has
been
focused
on
fusion
with
myeloid
cells,
phenomenon
may
result
in
hybrid
so-called
Tumour
Hybrid
Cells
(THCs),
enhanced
migratory,
angiogenic,
immune
evasion,
colonisation,
properties.
This
process
shown
potentially
drive
tumour
progression,
drug
resistance,
recurrence.
In
review,
we
explore
potential
govern
cell
fusion,
mediators
involved,
characteristics
acquired
by
fusion-derived
hybrids,
their
clinical
significance
human
cancer.
Additionally,
discuss
emerging
pharmacological
strategies
aimed
at
targeting
fusogenic
molecules
means
prevent
dissemination.
Journal of Surgical Oncology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
ABSTRACT
Circulating
tumor
cells
(CTCs)
are
that
detach
from
the
primary
site
and
enter
bloodstream.
They
hold
significant
value
for
early
detection,
diagnosis,
treatment
of
tumors.
CTC
detection
methods
can
be
classified
into
in
vivo
vitro
techniques.
Compared
to
traditional
methods,
causes
less
harm
body
allows
earlier
identification
malignant
tumors,
thereby
enabling
timely
improving
patient
survival
rates.
In
recent
years,
has
been
widely
used
assess
effectiveness
immunotherapy.
Dynamic
monitoring
CTCs
help
optimize
clinical
strategies.
This
review
summarizes
latest
discusses
their
applications
immunotherapy
various
common
aiming
provide
better
guidance
support
practice.