The emergence of multiscale connectomics-based approaches in stroke recovery DOI Creative Commons
Shahrzad Latifi, S. Thomas Carmichael

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(4), P. 303 - 318

Published: Feb. 23, 2024

Stroke is a leading cause of adult disability. Understanding stroke damage and recovery requires deciphering changes in complex brain networks across different spatiotemporal scales. While recent developments readout technologies progress network modeling have revolutionized current understanding the effects on at macroscale, reorganization smaller scale remains incompletely understood. In this review, we use conceptual framework graph theory to define from nano- macroscales. Highlighting stroke-related connectivity studies multiple scales, argue that multiscale connectomics-based approaches may provide new routes better evaluate structural functional remapping after during recovery.

Language: Английский

The High Cost of Stroke and Stroke Cytoprotection Research DOI
Paul A. Lapchak, John H. Zhang

Translational Stroke Research, Journal Year: 2016, Volume and Issue: 8(4), P. 307 - 317

Published: Dec. 30, 2016

Language: Английский

Citations

111
Enhancing endogenous capacity to repair a stroke-damaged brain: An evolving field for stroke research DOI Creative Commons
Li‐Ru Zhao,

Alison E. Willing

Progress in Neurobiology, Journal Year: 2018, Volume and Issue: 163-164, P. 5 - 26

Published: Feb. 21, 2018

Stroke represents a severe medical condition that causes stroke survivors to suffer from long-term and even lifelong disability. Over the past several decades, vast majority of research targets neuroprotection in acute phase, while little work has been done enhance recovery at later stage. Through reviewing current understanding brain plasticity, pathology, emerging preclinical clinical restorative approaches, this review aims provide new insights advance field for recovery. Lifelong plasticity offers long-lasting possibility repair stroke-damaged brain. impairs structural functional integrity entire networks; approaches containing multi-components have great potential maximize by rebuilding normalizing stroke-disrupted networks functioning. The window is much longer than previously thought. optimal time appears be stage rather earlier It expected these will our assist developing next generation enhancing after stroke.

Language: Английский

Citations

108
Human brain connectivity: Clinical applications for clinical neurophysiology DOI
Mark Hallett, Willem de Haan, Gustavo Deco

et al.

Clinical Neurophysiology, Journal Year: 2020, Volume and Issue: 131(7), P. 1621 - 1651

Published: April 22, 2020

Language: Английский

Citations

104
Treatments to Promote Neural Repair after Stroke DOI Creative Commons
Steven C. Cramer

Journal of Stroke, Journal Year: 2018, Volume and Issue: 20(1), P. 57 - 70

Published: Jan. 31, 2018

Stroke remains a major cause of human disability worldwide. In parallel with advances in acute stroke interventions, new therapies are under development that target restorative processes. Such have treatment time window measured days, weeks, or longer and so the advantage they may be accessible by majority patients. Several categories therapy been studied reviewed herein, including drugs, growth factors, monoclonal antibodies, activity-related telerehabilitation, host devices such as those related to brain stimulation robotics. Many patients do not receive them derive benefit, often surviving for years thereafter. Therapies based on neural repair hold promise providing additional options stroke. Keywords: Stroke; Neuronal plasticity; rehabilitation; Recovery function; Telerehabilitation

Language: Английский

Citations

100
MicroRNA-132 attenuates cerebral injury by protecting blood-brain-barrier in MCAO mice DOI
Xiaokun Zuo, Jianfei Lu,

Manaenko Anatol

et al.

Experimental Neurology, Journal Year: 2019, Volume and Issue: 316, P. 12 - 19

Published: March 28, 2019

Language: Английский

Citations

95
Filling the gaps on stroke research: Focus on inflammation and immunity DOI Creative Commons
Damien Levard, Izaskun Buendía, Anastasia Lanquetin

et al.

Brain Behavior and Immunity, Journal Year: 2020, Volume and Issue: 91, P. 649 - 667

Published: Oct. 2, 2020

Language: Английский

Citations

89
Virtual reality in neurorehabilitation: a review of its effects on multiple cognitive domains DOI
Giuseppe Riva, Valentina Mancuso, Silvia Cavedoni

et al.

Expert Review of Medical Devices, Journal Year: 2020, Volume and Issue: 17(10), P. 1035 - 1061

Published: Sept. 23, 2020

Neurological diseases frequently cause adult-onset disability and have increased the demand for rehabilitative interventions. Neurorehabilitation has been progressively relying on computer-assisted programs and, more recently, virtual reality (VR). Current reviews explore VR-based neurorehabilitation assessing treating most common neurological pathologies. However, none of them explored specifically impact VR multiple cognitive domains.The present work is a review 6 years literature (2015-2020) in with purpose analyzing its effects memory, attention, executive functions, language, visuospatial ability.Our suggests that showed encouraging results functions abilities particularly both acute neurodegenerative conditions. Conversely, attention outcomes are conflicting, language did not show significant improvements following rehabilitation. Within five years, it plausible intervention would be provided standalone mobile-based platforms won't need PC to work, reduced latency improved user interaction.

Language: Английский

Citations

81
Toll‐like receptors in neuroinflammation, neurodegeneration, and alcohol‐induced brain damage DOI Open Access
María Pascual, Maria Calvo‐Rodriguez, Lucı́a Núñez

et al.

IUBMB Life, Journal Year: 2021, Volume and Issue: 73(7), P. 900 - 915

Published: May 25, 2021

Toll-like receptors (TLRs) or pattern recognition respond to pathogen-associated molecular patterns (PAMPs) internal damage-associated (DAMPs). TLRs are integral membrane proteins with both extracellular leucine-rich and cytoplasmic domains that initiate downstream signaling through kinases by activating transcription factors like AP-1 NF-κB, which lead the release of various inflammatory cytokines immune modulators. In central nervous system, different expressed mainly in microglia astroglial cells, although some also oligodendroglia neurons. Activation triggers cascades host as a defense mechanism against invaders repair damaged tissue. However, overactivation disrupts sustained homeostasis-induced production pro-inflammatory molecules, such cytokines, miRNAs, components vesicles. These mediators can, turn, induce neuroinflammation, neural tissue damage associated many neurodegenerative diseases. This review discusses critical role response Alzheimer's disease, Parkinson's ischemic stroke, amyotrophic lateral sclerosis, alcohol-induced brain neurodegeneration.

Language: Английский

Citations

78
Diversity of Reactive Astrogliosis in CNS Pathology: Heterogeneity or Plasticity? DOI Creative Commons

Aaron J. Moulson,

Jordan W. Squair, Robin J.M. Franklin

et al.

Frontiers in Cellular Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: July 26, 2021

Astrocytes are essential for the development and homeostatic maintenance of central nervous system (CNS). They also critical players in CNS injury response during which they undergo a process referred to as "reactive astrogliosis." Diversity astrocyte morphology gene expression, revealed by transcriptional analysis, is well-recognized has been reported several pathologies, including ischemic stroke, demyelination, traumatic injury. This diversity appears unique specific pathology, with significant variance across temporal, topographical, age, sex-specific variables. Despite this, there limited functional data corroborating this diversity. Furthermore, reactive astrocytes display environmental-dependent plasticity fate-mapping on subsets adult limited, it remains unclear whether represents heterogeneity or plasticity. As important neuronal survival function post-injury, establishing what extent reflects distinct established heterogeneous subpopulations vs. environmentally dependent within will be guiding therapeutic development. To that end, we review current state knowledge context three representative pathologies: injury, goal identifying key limitations our suggesting future areas research needed address them. We suggest majority identified pathologies date dynamically changing post-injury environments opposed heterogeneity, an consideration understanding disease pathogenesis interventions.

Language: Английский

Citations

69
Neuroplasticity of Acupuncture for Stroke: An Evidence-Based Review of MRI DOI Creative Commons
Jinhuan Zhang,

Chunjian Lu,

Xiaoxiong Wu

et al.

Neural Plasticity, Journal Year: 2021, Volume and Issue: 2021, P. 1 - 14

Published: Aug. 19, 2021

Acupuncture is widely recognized as a potentially effective treatment for stroke rehabilitation. Researchers in this area are actively investigating its therapeutic mechanisms. Magnetic resonance imaging (MRI), noninvasive, high anatomical resolution technique, has been employed to investigate neuroplasticity on acupuncture patients from system level. However, there no review the mechanism of based MRI. Therefore, we aim summarize current evidence about aspect and provide useful information future research. After searching PubMed, Web Science, Embase databases, 24 human five animal studies were identified. This focuses possible mechanisms underlying therapy treating by regulating brain plasticity. We found that reorganizes not only motor-related network, including primary motor cortex (M1), premotor cortex, supplementary (SMA), frontoparietal network (LFPN RFPN), sensorimotor (SMN), well default mode (aDMN pDMN), but also language-related areas inferior frontal gyrus frontal, temporal, parietal, occipital lobes, cognition-related regions. In addition, can modulate function structural plasticity post-stroke, which may be linked effect acupuncture.

Language: Английский

Citations

60