Immunomodulation: The next target of mesenchymal stem cell-derived exosomes in the context of ischemic stroke DOI Creative Commons
Xiaoqian Shan, Yongyin Luo, Jun Chang

et al.

World Journal of Stem Cells, Journal Year: 2023, Volume and Issue: 15(3), P. 52 - 70

Published: March 22, 2023

Ischemic stroke (IS) is the most prevalent form of brain disease, characterized by high morbidity, disability, and mortality. However, there still a lack ideal prevention treatment measures in clinical practice. Notably, transplantation therapy mesenchymal stem cells (MSCs) has been hot research topic stroke. Nevertheless, are risks associated with this cell therapy, including tumor formation, coagulation dysfunction, vascular occlusion. Also, growing number studies suggest that therapeutic effect after MSCs mainly attributed to MSC-derived exosomes (MSC-Exos). And cell-free mediated appears circumvent many difficulties when compared it may be promising new strategy for treating as replacement therapy. Studies suppressing inflammation via modulation immune response an additional option IS. Intriguingly, MSC-Exos mediates inflammatory following IS modulating central nervous system, peripheral immunomodulatory molecules, thereby promoting neurofunctional recovery Thus, paper reviews role, potential mechanisms, post-IS order identify targets.

Language: Английский

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review DOI Creative Commons
Jinsong Zeng, Tingting Bao, Kailin Yang

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 13

Published: Feb. 2, 2023

Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and oxidative stress play important roles in various complex mechanisms IS. In particular, early proinflammatory response resulting from overactivation resident microglia infiltration circulating monocytes macrophages brain after cerebral ischemia leads to secondary injury. Microglia are innate immune cells that constantly monitor microenvironment under normal conditions. Once occurs, activated produce dual effects neurotoxicity neuroprotection, balance two determines fate damaged neurons. The activation defined as classical (M1 type) or alternative (M2 type). M1 type secrete pro-inflammatory cytokines neurotoxic mediators exacerbate neuronal damage, while M2 promote a repairing anti-inflammatory response. Fine regulation M1/M2 microglial minimize damage maximize protection has therapeutic value. This review focuses on interaction between other involved IS phenotypic characteristics, mechanism natural plant components regulating IS, providing novel candidate drugs for drug development.

Language: Английский

Citations

78
Neuroimmune mechanisms and therapies mediating post-ischaemic brain injury and repair DOI
Takashi Shichita, Hiroaki Ooboshi, Akihiko Yoshimura

et al.

Nature reviews. Neuroscience, Journal Year: 2023, Volume and Issue: 24(5), P. 299 - 312

Published: March 27, 2023

Language: Английский

Citations

60
Neuroinflammation as a Key Driver of Secondary Neurodegeneration Following Stroke? DOI Open Access
Shannon M. Stuckey, Lin Kooi Ong, Lyndsey E. Collins‐Praino

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(23), P. 13101 - 13101

Published: Dec. 3, 2021

Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly due to an arterial blockage in a specific region brain. Stroke is leading cause death and common disability, with over 17 million people worldwide suffering from each year. It now well-documented that neuroinflammation immune mediators play key role acute long-term neuronal tissue damage healing, not only infarct core but also distal regions. Importantly, these regions, termed sites secondary neurodegeneration (SND), spikes may be seen sometime after initial onset, prior presence within However, it acknowledge that, despite mounting information describing following ischaemic stroke, exact mechanisms whereby inflammatory cells their drive stroke-induced are still fully understood. As result, current anti-inflammatory treatments have failed show efficacy clinical trials. In this review we discuss complexities post-stroke neuroinflammation, specifically how affects outcome acutely, chronically, SND. We then previously assessed therapies, particular focus on anti-inflammatories repurposed target SND-associated neuroinflammation.

Language: Английский

Citations

100
Neutrophil Extracellular Traps Exacerbate Ischemic Brain Damage DOI

Congqin Li,

Ying Xing, Yuqian Zhang

et al.

Molecular Neurobiology, Journal Year: 2021, Volume and Issue: 59(1), P. 643 - 656

Published: Nov. 8, 2021

Language: Английский

Citations

68
Tat-NTS peptide protects neurons against cerebral ischemia-reperfusion injury via ANXA1 SUMOylation in microglia DOI Creative Commons
Huijuan Zhou, Lulu Yan, He‐Zhou Huang

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5561 - 5583

Published: Jan. 1, 2023

Rationale:Recent studies indicate that microglial activation and the resulting inflammatory response could be potential targets of adjuvant therapy for ischemic stroke.Many have emphasized a well-established function Annexin-A1 (ANXA1) in immune system, including regulation activation.Nevertheless, few therapeutic interventions targeting ANXA1 microglia stroke been conducted.In present study, Tat-NTS, small peptide developed to prevent from entering nucleus, was utilized.We discovered underlying mechanism Tat-NTS protect against brain injury.Methods: Preclinical were performed using an oxygen-glucose deprivation reperfusion (OGD/R) cell model vitro middle cerebral artery occlusion (MCAO) animal vivo.Confocal imaging 3D reconstruction analyses detecting protein expression subcellular localization vivo.Co-immunoprecipitation (Co-IP), immunoblotting, ELISA, quantitative real-time PCR (qRT-PCR), Luciferase reporter assay determining precise molecular mechanism.Measurement on cytotoxicity assessed by CCK-8 LDH assay.TUNEL staining used detect conditioned medium-mediated neuronal apoptosis.Adeno-associated viruses (AAVs) injected into cortex, striatum hippocampal CA1 region adult male Cx3cr1-Cre mice, further verify neurofunctional outcome TTC staining, modified Neurological Severity Score (mNSS) test, open field test (OFT), novel object recognition task (NORT), Morris water maze (MWM) long-term potentiation (LTP) Transmission electron microscopy (TEM). Results:It observed administration led shift nucleus cytoplasm injury.Notably, this accompanied increase SUMOylation transformation towards anti-inflammatory phenotype.We confirmed Tat-NTS-induced mediated IKKα degradation via NBR1-dependent selective autophagy, then blocking NF-κB pathway.As result, release pro-inflammatory factors IL-1β TNF-α reduced both vivo experiments.Furthermore, we found peptide's protective effect relieved neuron apoptosis.Finally, Ivyspring

Language: Английский

Citations

28
Association between blood inflammatory indices and heart failure: a cross-sectional study of NHANES 2009-2018 DOI Creative Commons
Yayun Zhang, Feng Lu,

Zixiong Zhu

et al.

Acta Cardiologica, Journal Year: 2024, Volume and Issue: 79(4), P. 473 - 485

Published: April 20, 2024

Inflammation plays a pivotal role in the pathogenesis of heart failure (HF). This study was aimed to potential association between complete blood cell count (CBC)-derived inflammatory biomarkers and HF.

Language: Английский

Citations

17
Anti-neuroinflammatory agent rhein lysinate-based self-assembled injectable hydrogel loaded with ZL006 for promoting post-stroke functional recovery DOI

Jiamei Song,

Jiaqi Zeng,

Xialin Chen

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123124 - 123124

Published: Jan. 1, 2025

Language: Английский

Citations

1
Enhanced Nasal-to-Brain Drug Delivery by Multivalent Bioadhesive Nanoparticle Clusters for Cerebral Ischemic Reperfusion Injury Protection DOI

Yizhen Jia,

Xiaohan Kong, Rui Li

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Brothers in arms: platelets and neutrophils in ischemic stroke DOI
Frederik Denorme, John L. Rustad, Robert A. Campbell

et al.

Current Opinion in Hematology, Journal Year: 2021, Volume and Issue: 28(5), P. 301 - 307

Published: June 28, 2021

Purpose of review In this review, we will describe how the combined ability platelets and neutrophils to interact with each other drives ischemic stroke brain injury. Recent findings Neutrophils are one first cells respond during stroke. Although animals models have indicated targeting improves outcomes, clinical trials failed yield successful strategies. Platelets play a critical role in recruiting sites injury by acting as bridge injured endothelium. After initial platelet adhesion, can rapidly bind through P-selectin glycoprotein Ibα. addition, recent data implicated phosphatidylserine novel key regulator platelet-neutrophil interactions setting Inhibition procoagulant decreases circulating aggregates thereby reduces infarct size. Platelet binding alters neutrophil function, which contributes associated This includes inducing release extracellular traps, neurotoxic pro-thrombotic, leading impaired outcomes. Summary Platelet-neutrophil significantly contribute pathophysiology Better understanding mechanisms behind their formation downstream consequences lead improved therapies for patients.

Language: Английский

Citations

42
Mesenchymal Stem Cells: Therapeutic Mechanisms for Stroke DOI Open Access
Yuchen Zhang,

Naijun Dong,

Huanle Hong

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2550 - 2550

Published: Feb. 25, 2022

Due to aging of the world’s population, stroke has become increasingly prevalent, leading a rise in socioeconomic burden. In recent past, research and treatment have key scientific issues that need urgent solutions, with sharp focus on stem cell transplantation, which is known treat neurodegenerative diseases related traumatic brain injuries, such as stroke. Indeed, therapy brought hope many patients, both animal clinical trials. Mesenchymal cells (MSCs) are most commonly utilized biological medical research, due their pluripotency universality. MSCs often obtained from adipose tissue bone marrow, transplanted via intravenous injection. Therefore, this review will discuss therapeutic mechanisms extracellular vehicles (EVs) secreted by for stroke, attenuating inflammation through immunomodulation, releasing trophic factors promote effects, inducing angiogenesis, promoting neurogenesis, reducing infarct volume, replacing damaged cells.

Language: Английский

Citations

37