Scientific Reports,
Journal Year:
2020,
Volume and Issue:
10(1)
Published: Feb. 28, 2020
Abstract
Primary
motor
cortex
(M1)
infarctions
sometimes
cause
sensory
impairment.
Because
signals
play
a
vital
role
in
control,
impairment
compromises
the
recovery
and
rehabilitation
of
disability.
However,
neural
mechanism
is
poorly
understood.
We
show
that
processing
mouse
primary
somatosensory
(S1)
was
impaired
acute
phase
M1
recovered
layer-specific
manner
subacute
phase.
This
layer-dependent
process
anatomical
connection
pattern
from
to
S1
suggested
functional
connectivity
plays
key
A
simulation
study
demonstrated
loss
inhibition
could
impair
S1,
compensation
for
recover
temporal
coding.
Consistently,
optogenetic
activation
suppressed
sustained
response
S1.
Taken
together,
we
revealed
how
focal
stroke
alters
cortical
network
activity
processing,
which
inhibitory
input
may
be
involved.
Frontiers in Neuroscience,
Journal Year:
2021,
Volume and Issue:
15
Published: May 28, 2021
Ischemic
stroke
is
one
of
the
main
central
nervous
system
diseases
and
associated
with
high
disability
mortality
rates.
Recombinant
tissue
plasminogen
activator
(rt-PA)
mechanical
thrombectomy
are
optimal
therapies
available
currently
to
restore
blood
flow
in
patients
stroke;
however,
their
limitations
well
recognized.
Therefore,
new
treatments
urgently
required
overcome
these
shortcomings.
Recently,
stem
cell
transplantation
technology,
involving
induced
pluripotent
cells
(iPSCs),
has
drawn
interest
neuroscientists
considered
be
a
promising
alternative
for
ischemic
treatment.
iPSCs
class
produced
by
introducing
specific
transcription
factors
into
somatic
cells,
similar
embryonic
biological
function.
Here,
we
have
reviewed
current
applications
focus
on
iPSC
therapy
stroke,
including
neuroprotective
mechanisms,
development
constraints,
major
challenges
overcome,
clinical
prospects.
Based
state
research,
believe
that
especially
iPSCs,
will
pave
way
future
BMJ Open,
Journal Year:
2021,
Volume and Issue:
11(8), P. e051790 - e051790
Published: Aug. 1, 2021
Stroke
is
a
serious
public
health
problem,
given
it
major
cause
of
disability
worldwide
despite
the
spread
recanalisation
therapies.
Enhancement
brain
plasticity
with
stem
cell
administration
promising
innovative
therapy
to
reduce
sequelae
in
these
patients.
International Journal of Medical Sciences,
Journal Year:
2022,
Volume and Issue:
19(7), P. 1155 - 1162
Published: Jan. 1, 2022
Ischemic
stroke
is
one
of
the
leading
causes
death
and
disability.Ischemia
triggers
a
cascade
events
to
cell
cerebral
infarction.Mesenchymal
stem
(MSC)
therapy
promising
treatment
modality
promote
development
nerve
blood
vessels
improve
function.However,
MSCs
have
limited
therapeutic
effect
in
harsh
microenvironment
ischemic
brain
tissue.Modified
MSC
shows
better
under
different
pathological
conditions,
expected
be
translated
into
clinical
practice.In
this
article,
we
review
latest
advances
modified
for
ischemia.In
particular,
summarize
targets
involved
migration,
homing,
antioxidant
stress,
anti-inflammatory,
vascular
regeneration,
providing
new
ideas
transformation.
Current Neuropharmacology,
Journal Year:
2021,
Volume and Issue:
20(3), P. 630 - 647
Published: Aug. 9, 2021
Stroke
is
a
major
challenge
in
neurology
due
to
its
multifactorial
genesis
and
irreversible
consequences.
Processes
of
endogenous
post-stroke
neurogenesis,
although
insufficient,
may
indicate
possible
direction
future
therapy.
Multiple
research
considers
stem-cell-based
approaches
order
maximize
neuroregeneration
minimize
deficits.Aim
this
study
review
current
literature
considering
stem-cell-
based
therapy
possibilities
inducing
after
brain
vascular
damage.Papers
included
article
were
obtained
from
PubMed
MEDLINE
databases.
The
following
medical
subject
headings
(MeSH)
used:
"stem
cell
therapy",
"post-stroke
neurogenesis",
"stem-cells
stroke",
"stroke
stem
cells",
"stroke",
"cell
"neuroregeneration",
"neurogenesis",
"stem-cell
human",
human".
Ultimate
inclusion
was
made
manual
the
reference
list.Attempts
stimulating
stroke
found
include
supporting
different
routes
exogenous
cells
supplying
extracellular
vesicles
used
as
method
particle
transport.Although
further
field
required,
post
recovery
supported
by
seems
be
promising
revolutionizing
modern
neurology.
Scientific Reports,
Journal Year:
2020,
Volume and Issue:
10(1)
Published: Feb. 28, 2020
Abstract
Primary
motor
cortex
(M1)
infarctions
sometimes
cause
sensory
impairment.
Because
signals
play
a
vital
role
in
control,
impairment
compromises
the
recovery
and
rehabilitation
of
disability.
However,
neural
mechanism
is
poorly
understood.
We
show
that
processing
mouse
primary
somatosensory
(S1)
was
impaired
acute
phase
M1
recovered
layer-specific
manner
subacute
phase.
This
layer-dependent
process
anatomical
connection
pattern
from
to
S1
suggested
functional
connectivity
plays
key
A
simulation
study
demonstrated
loss
inhibition
could
impair
S1,
compensation
for
recover
temporal
coding.
Consistently,
optogenetic
activation
suppressed
sustained
response
S1.
Taken
together,
we
revealed
how
focal
stroke
alters
cortical
network
activity
processing,
which
inhibitory
input
may
be
involved.
