LncRNA BIRF Promotes Brain Ischemic Tolerance Induced By Cerebral Ischemic Preconditioning Through Upregulating GLT-1 via Sponging miR-330-5p DOI Creative Commons
Shichao Li, Lingyan Zhang, Jiajie Lin

et al.

Molecular Neurobiology, Journal Year: 2022, Volume and Issue: 59(7), P. 3996 - 4014

Published: April 22, 2022

Long noncoding RNAs (lncRNAs) play an important regulatory role in various diseases. However, the of lncRNAs brain ischemic tolerance (BIT) induced by cerebral preconditioning (CIPC) is still unknown. The lncRNA profile rat cortical astrocytes pretreated with was analyzed high-throughput sequencing. results Cell-Counting Kit-8 (CCK-8) assay showed that a novel lncRNA, NONRATT009133.2, which we referred to as ischemia-related factor (BIRF), highly correlated BIT. Through bioinformatics analysis, predicted BIRF, miR-330-5p, and GLT-1 (also named Slc1a2) might constitute ceRNA network induction We found BIRF upregulated CIPC, promoted expression BIT induction. could directly bind miR-330-5p. Furthermore, miR-330-5p targeted GLT-1, inhibited both vitro vivo. Moreover, acts molecular sponge competitively mRNA, while inhibitor reversed all effects siRNA on neuronal vitality. Taken together, our demonstrate roles BIRF/miR-330-5p/GLT-1 axis CIPC. may be potentially effective therapeutic strategy against stroke injury.

Language: Английский

LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond DOI Creative Commons
Wanxu Huang, Hua Li,

Qingsong Yu

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2022, Volume and Issue: 41(1)

Published: March 15, 2022

DNA methylation is one of the most important epigenetic mechanisms to regulate gene expression, which highly dynamic during development and specifically maintained in somatic cells. Aberrant patterns are strongly associated with human diseases including cancer. How cell-specific established or disturbed a pivotal question developmental biology cancer epigenetics. Currently, compelling evidence has emerged that long non-coding RNA (lncRNA) mediates both physiological pathological conditions. In this review, we provide an overview current understanding lncRNA-mediated methylation, emphasis on roles mechanism cancer, best our knowledge, not been systematically summarized. addition, also discuss potential clinical applications RNA-targeting drug development.

Language: Английский

Citations

144
Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance DOI Creative Commons
Chunjie Huang, Paniz Azizi,

Masoud Vazirzadeh

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Sept. 13, 2023

Abstract Cancer is a complex disease with many contributing factors, and researchers have gained extensive knowledge that has helped them understand the diverse varied nature of cancer. The altered patterns DNA methylation found in numerous types cancer imply they may play part disease’s progression. human condition involves dysregulation methyltransferase 3 beta (DNMT3B) gene, prominent de novo methyltransferase, its abnormal behavior serves as an indicator for tumor prognosis staging. expression non-coding RNAs (ncRNAs), which include microRNAs (miRNA), long (lncRNAs), circular (circRNAs), critical controlling targeted gene protein translation their correlates onset tumors. NcRNAs factor influences modulation several cellular characteristics cancerous cells. These but are not limited to, drug responsiveness, angiogenesis, metastasis, apoptosis, proliferation, properties stem cell. reciprocal regulation ncRNAs DNMT3B can act synergy to influence destiny Thus, avenue advancing prevention treatment inquiry into interplay between ncRNAs. In this review, we present comprehensive overview ncRNAs/DNMT3B axis pathogenesis. This brings about valuable insights intricate mechanisms tumorigenesis provides foundation developing effective therapeutic interventions.

Language: Английский

Citations

29
Body fluid multiomics in 3PM-guided ischemic stroke management: health risk assessment, targeted protection against health-to-disease transition, and cost-effective personalized approach are envisaged DOI Creative Commons
Ruofei Chen, Xiaoyan Wang,

Na Li

et al.

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(3), P. 415 - 452

Published: Aug. 29, 2024

Because of its rapid progression and frequently poor prognosis, stroke is the third major cause death in Europe first one China. Many independent studies demonstrated sufficient space for prevention interventions primary care ischemic defined as most cost-effective protection vulnerable subpopulations against health-to-disease transition. Although several identified molecular patterns specific IS body fluids, none these approaches has yet been incorporated into treatment guidelines. The advantages disadvantages individual fluids are thoroughly analyzed throughout paper. For example, multiomics based on a minimally invasive approach utilizing blood components recommended real-time monitoring, due to particularly high level dynamics system. On other hand, tear fluid more stable system non-invasive patient-friendly holistic appropriate health risk assessment innovative screening programs management. This article details aspects essential promote practical implementation highlighted achievements 3PM-guided

Language: Английский

Citations

8
Long Non-coding RNAs as Promising Therapeutic Approach in Ischemic Stroke: a Comprehensive Review DOI Creative Commons
M Wolska, Joanna Jarosz-Popek, Eva Junger

et al.

Molecular Neurobiology, Journal Year: 2020, Volume and Issue: 58(4), P. 1664 - 1682

Published: Nov. 24, 2020

Abstract In recent years, ischemic stroke (IS) has been one of the major causes disability and mortality worldwide. The general mechanism IS is based on reduced blood supply to neuronal tissue, resulting in cell damage by various pathological reactions. One main techniques for acute treatment entails advanced surgical approaches restoration cerebral but this often associated with secondary brain injury, also known as reperfusion injury (I/R injury). Many researches have come emphasize significant role long non-coding RNAs (lncRNAs) IS, especially I/R their potential therapeutic approaches. LncRNAs are non-protein transcripts that able regulate cellular processes gene expression. Further, lncRNAs shown be involved signaling pathways. Several recognized key factors physiological IS. review, we discuss mechanisms association neuroprotection. Moreover, identify show greatest novel which therefore merit further investigation preclinical research.

Language: Английский

Citations

39
Level of LncRNA GAS5 and Hippocampal Volume are Associated with the Progression of Alzheimer’s Disease DOI Creative Commons
Xiaopeng Chen,

Guoqiang Ren,

Yan Li

et al.

Clinical Interventions in Aging, Journal Year: 2022, Volume and Issue: Volume 17, P. 745 - 753

Published: May 1, 2022

We evaluated the diagnostic value of long non-coding RNA growth arrest-specific transcript 5 (GAS5) and its relationship with hippocampal volume in Alzheimer's disease (AD). One hundred eight patients AD 83 healthy controls were included, demographic data, biochemical parameters, GAS5 levels, recorded. Chi-squared tests or independent sample t-tests used to compare baseline characteristics, relative expression GAS5, volume. Correlations between variables determined using Spearman's rank correlation test. Receiver operating characteristic (ROC) curves generated total AD. The levels significantly upregulated compared those negatively correlated MMSE score. There differences left volume, right two groups. Total was positively score area under curve (AUC) for 0.831, sensitivity 61.1%, specificity 95.2%. AUC combined 0.891, 74.1%, 92.8%. results suggested that may be an excellent indicator progression alone combination

Language: Английский

Citations

21
MRPS9-Mediated Regulation of the PI3K/Akt/mTOR Pathway Inhibits Neuron Apoptosis and Protects Ischemic Stroke DOI

Jina Jiang,

Tingting Qi,

Li Li

et al.

Journal of Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 74(1)

Published: Feb. 21, 2024

Language: Английский

Citations

5
Epigenetic mechanisms and potential therapeutic targets in stroke DOI
Kahlilia C. Morris-Blanco, Anil K. Chokkalla, Vijay Arruri

et al.

Journal of Cerebral Blood Flow & Metabolism, Journal Year: 2022, Volume and Issue: 42(11), P. 2000 - 2016

Published: July 19, 2022

Accumulating evidence indicates a central role for epigenetic modifications in the progression of stroke pathology. These mechanisms are involved complex and dynamic processes that modulate post-stroke gene expression, cellular injury response, motor function, cognitive ability. Despite decades research, continues to be classified as leading cause death disability worldwide with limited clinical interventions. Thus, technological advances field epigenetics may provide innovative targets develop new therapies. This review presents on impact epigenomic readers, writers, erasers both ischemic hemorrhagic pathophysiology. We specifically explore DNA methylation, hydroxymethylation, histone modifications, regulation by long non-coding RNAs modulating expression functional outcome after stroke. Furthermore, we highlight promising pharmacological approaches biomarkers relation translational therapeutic applications.

Language: Английский

Citations

19
Downregulation of ELAVL1 attenuates ferroptosis-induced neuronal impairment in rats with cerebral ischemia/reperfusion via reducing DNMT3B-dependent PINK1 methylation DOI
Yun Du, Ru Zhang, Guilian Zhang

et al.

Metabolic Brain Disease, Journal Year: 2022, Volume and Issue: 37(8), P. 2763 - 2775

Published: Sept. 29, 2022

Language: Английский

Citations

17
Myricetin improves apoptosis after ischemic stroke via inhibiting MAPK-ERK pathway DOI
Lei Zhang, Tai Zhou, Qiaorong Ji

et al.

Molecular Biology Reports, Journal Year: 2023, Volume and Issue: 50(3), P. 2545 - 2557

Published: Jan. 8, 2023

Language: Английский

Citations

10
Single-cell RNA sequencing reveals that VIM and IFITM3 are vital targets of Dengzhan Shengmai capsule to protect against cerebral ischemic injury DOI
Guangzhao Cao, Jingyi Hou, Rui Zhou

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 311, P. 116439 - 116439

Published: March 31, 2023

Language: Английский

Citations

10