Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(2), P. 163 - 205

Published: April 18, 2024

Despite their subordination in humans, to a great extent, mitochondria maintain independent status but tightly cooperate with the "host" on protecting joint life quality and minimizing health risks. Under oxidative stress conditions, healthy promptly increase mitophagy level remove damaged "fellows" rejuvenating mitochondrial population sending fragments of mtDNA as SOS signals all systems human body. As long metabolic pathways are under systemic control well-concerted together, adaptive mechanisms become triggered increasing protection, activating antioxidant defense repair machinery. Contextually, attributes patho-/physiology instrumental for predictive medical approach cost-effective treatments tailored individualized patient profiles primary (to protect vulnerable individuals again health-to-disease transition) secondary affected disease progression) care. Nutraceuticals naturally occurring bioactive compounds demonstrating health-promoting, illness-preventing, other health-related benefits. Keeping mind health-promoting properties nutraceuticals along therapeutic potential safety profile, there is permanently growing demand application mitochondria-relevant nutraceuticals. Application beneficial only if meeting needs at individual level. Therefore, risk assessment creation pivotal importance followed by adapted nutraceutical sets needs. Based scientific evidence available nutraceuticals, this article presents examples frequent which require protective measures targeted holistic following advanced concepts predictive, preventive, personalized medicine (PPPM/3PM)

Language: Английский

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Energy metabolism as the hub of advanced non-small cell lung cancer management: a comprehensive view in the framework of predictive, preventive, and personalized medicine

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(2), P. 289 - 319

Published: April 8, 2024

Abstract Energy metabolism is a hub of governing all processes at cellular and organismal levels such as, on one hand, reparable vs. irreparable cell damage, fate (proliferation, survival, apoptosis, malignant transformation etc.), and, the other carcinogenesis, tumor development, progression metastazing versus anti-cancer protection cure. The orchestrator mitochondria who produce, store invest energy, conduct intracellular systemically relevant signals decisive for internal environmental stress adaptation, coordinate corresponding levels. Consequently, quality mitochondrial health homeostasis reliable target risk assessment stage reversible damage to followed by cost-effective personalized against health-to-disease transition as well targeted disease (secondary care cancer patients growing primary tumors metastatic disease). energy reprogramming non-small lung (NSCLC) attracts particular attention clinically instrumental paradigm change from reactive medical services predictive, preventive medicine (3PM). This article provides detailed overview towards mechanisms biological pathways involving metabolic (MR) with respect inhibiting synthesis biomolecules blocking common NSCLC anti-NSCLC therapeutic strategies. For instance, mitophagy recycles macromolecules yield substrates nucleotide synthesis. Histone modification DNA methylation can predict onset diseases, plasma C7 analysis an efficient service potentially resulting in optimized healthcare economy areas. MEMP scoring guidance immunotherapy, prognostic assessment, drug development. Metabolite sensing nutrients their derivatives are potential MR-related therapy NSCLC. Moreover, miR-495-3p sphingolipid rheostat targeting Sphk1, 22/FOXM1 axis regulation, A2 receptor antagonist highly promising TFEB biomarker predicting immune checkpoint blockade redox-related lncRNA signature (redox-LPS) considered predictive approaches. Finally, exemplified this phenotyping innovative population screening, multi-level diagnostics, prevention, treatment algorithms tailored patient profiles—all essential pillars 3PM approach overall management cancers. highlights innovation focused advance benefiting vulnerable subpopulations, affected patients, large.

Language: Английский

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Targeting selective autophagy and beyond: From underlying mechanisms to potential therapies

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: 65, P. 297 - 327

Published: May 14, 2024

Autophagy is an evolutionarily conserved turnover process for intracellular substances in eukaryotes, relying on lysosomal (in animals) or vacuolar yeast and plants) mechanisms. In the past two decades, emerging evidence suggests that, under specific conditions, autophagy can target particular macromolecules organelles degradation, a termed selective autophagy. Recently, accumulating studies have demonstrated that abnormality of closely associated with occurrence progression many human diseases, including neurodegenerative cancers, metabolic cardiovascular diseases. This review aims at systematically comprehensively introducing its role various while unravelling molecular mechanisms By providing theoretical basis development related small-molecule drugs as well treating this seeks to contribute understanding therapeutic potential. review, we introduce dissect major categories been discovered. We also focus recent advances underlying both classical non-classical Moreover, current situation targeting different types further summarized, valuable insights into discovery more candidate future. On other hand, reveal clinically relevant implementations are potentially autophagy, such predictive approaches treatments tailored individual patients.

Language: Английский

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Digital biomarkers: 3PM approach revolutionizing chronic disease management — EPMA 2024 position

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(2), P. 149 - 162

Published: May 11, 2024

Abstract Non-communicable chronic diseases (NCDs) have become a major global health concern. They constitute the leading cause of disabilities, increased morbidity, mortality, and socio-economic disasters worldwide. Medical condition-specific digital biomarker (DB) panels emerged as valuable tools to manage NCDs. DBs refer measurable quantifiable physiological, behavioral, environmental parameters collected for an individual through innovative technologies, including wearables, smart devices, medical sensors. By leveraging healthcare providers can gather real-time data insights, enabling them deliver more proactive tailored interventions individuals at risk patients diagnosed with Continuous monitoring relevant wearable devices or smartphone applications allows clinicians track progression NCDs in real time. With introduction (DBM), new quality primary secondary is being offered promising opportunities assessment protection against health-to-disease transitions vulnerable sub-populations. DBM enables take most cost-effective targeted preventive measures, detect disease developments early, introduce personalized interventions. Consequently, they benefit life (QoL) affected individuals, economy, society large. instrumental paradigm shift from reactive services 3PM approach promoted by European Association Predictive, Preventive, Personalized Medicine (EPMA) involving experts 55 countries This position manuscript consolidates multi-professional expertise area, demonstrating clinically examples providing roadmap implementing concepts facilitated DBs.

Language: Английский

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Mitochondria in cutaneous health, disease, ageing and rejuvenation—the 3PM-guided mitochondria-centric dermatology

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Association of both intrinsic and extrinsic risk factors leading to accelerated skin ageing is reflected in excessive ROS production ir/reversible mitochondrial injury burnout, as abundantly demonstrated by accumulating research data. Due the critical role stress pathophysiology disorders, maintained (primary care) restored (secondary health, rejuvenation homoeostasis are considered most effective holistic approach advance dermatological treatments based on systemic health-supportive stimulating measures. Per evidence, an anti-ageing protection, wound healing scarring quality - all strongly depend sustainable functionality well-balanced homoeostasis. The latter can be objectively measured and, if necessary, a manner pre- rehabilitation algorithms tailored individualised patient profiles. entire spectrum corresponding innovations area includes natural rejuvenation, aesthetic reconstructive medicine, protection targeted disorders. Contextually, mitochondria-centric dermatology instrumental for advanced 3PM-guided which makes good use predictive multi-level diagnostics against health-to-disease transition progression relevant Cost-effective new treatment avenues focused health physiologic proposed article including in-depth analysis cases exemplified care with detailed mechanisms expert recommendations presented.

Language: Английский

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Artificial intelligence in ovarian cancer drug resistance advanced 3PM approach: subtype classification and prognostic modeling

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(3), P. 525 - 544

Published: July 13, 2024

Language: Английский

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Body fluid multiomics in 3PM-guided ischemic stroke management: health risk assessment, targeted protection against health-to-disease transition, and cost-effective personalized approach are envisaged

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(3), P. 415 - 452

Published: Aug. 29, 2024

Because of its rapid progression and frequently poor prognosis, stroke is the third major cause death in Europe first one China. Many independent studies demonstrated sufficient space for prevention interventions primary care ischemic defined as most cost-effective protection vulnerable subpopulations against health-to-disease transition. Although several identified molecular patterns specific IS body fluids, none these approaches has yet been incorporated into treatment guidelines. The advantages disadvantages individual fluids are thoroughly analyzed throughout paper. For example, multiomics based on a minimally invasive approach utilizing blood components recommended real-time monitoring, due to particularly high level dynamics system. On other hand, tear fluid more stable system non-invasive patient-friendly holistic appropriate health risk assessment innovative screening programs management. This article details aspects essential promote practical implementation highlighted achievements 3PM-guided

Language: Английский

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Mitochondria-based holistic 3PM approach as the ‘game-changer’ for individualised rehabilitation—the proof-of-principle model by treated breast cancer survivors

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(4), P. 559 - 571

Published: Nov. 20, 2024

Breast cancer belongs to the most commonly diagnosed malignancies worldwide, with its increasing incidence paralleled by advances in early diagnostics and effective treatments resulting significantly improved survival rates. However, breast survivors often experience reduced quality of life linked long-term health burden as a consequence aggressive oncological applied. Their frequently recorded complains include chronic fatigue, physical activity, disordered sleep, chronification pain, severe mental impairments-all per evidence are associated compromised mitochondrial impaired homeostasis. Self-report survivor is included this article illustrate currently uncovered patient needs. This highlights mechanisms behind suboptimal damage, introduces novel, mitochondria-based holistic approach addressing rehabilitation concepts for following advanced principles predictive, preventive personalised medicine (3PM). By operating via function, proposed triggers systemic effects at molecular, sub/cellular organismal levels positively affecting energy metabolism, repair well creating, therefore, highly algorithms tailored an individualised profile. The methodology integrates assessments utilising homeostasis biomarkers tear fluid non-invasive diagnostic tool, nutraceuticals lifestyle adjustments. introduced aligns 3PM, offering proactive framework managing persistent post-treatment symptoms cohort survivors. Furthermore, presented also applicable pre-habilitation programmes considering needs other cohorts affected diseases such CVD orthopaedic disorders planned major surgical incisions, who require individually adapted pre- programmes. Implementing innovative strategies may lead full recovery, sustainable conditions and, facilitating patients' comeback normal daily activities, family professional life. Contextually, considered 'proof-of-principle' model 3PM-related paradigm shift from reactive cost-effective management both primary secondary care benefiting large spectrum cohorts, individuals society large.

Language: Английский

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Changes in the triglyceride-glucose-body mass index estimate the risk of hypertension among the middle-aged and older population: a prospective nationwide cohort study in China in the framework of predictive, preventive, and personalized medicine

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(4), P. 611 - 627

Published: Oct. 8, 2024

Language: Английский

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Mass spectrometry-based analysis of eccrine sweat supports predictive, preventive and personalised medicine in a cohort of breast cancer patients in Austria

The EPMA Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Metabolomics measurements of eccrine sweat may provide novel and relevant biomedical information to support predictive, preventive personalised medicine (3PM). However, only limited data is available regarding metabolic alterations accompanying chemotherapy breast cancer patients related residual burden (RCB) or therapy response. Here, we have applied Metabo-Tip, a non-invasive metabolomics assay based on the analysis from fingertips, investigate feasibility such an approach, especially with respect drug monitoring, assessing lifestyle parameters stratification patients. Eccrine samples were collected (n = 9) during first cycle neoadjuvant at four time points in this proof-of-concept study Tertiary University Hospital. Metabolites analysed using mass spectrometry. Blood plasma same timepoints also validated targeted kit, addition proteomics fatty acids/oxylipin analysis. A total 247 exogenous small molecules endogenous metabolites identified Cyclophosphamide ondansetron successfully detected monitored individual accurately reflected administration schedule. The non-essential amino acids asparagine, serine proline, as well ornithine significantly regulated blood over cycle. their distinct time-dependent profiles indicated compartment-specific distributions. Indeed, metabolite composition seems largely resemble interstitial fluid. Plasma proteins acids/oxylipins not affected by treatment Individual smoking habit was revealed simultaneous detection nicotine its primary cotinine sweat. Stratification according RCB pronounced differences these baseline, e.g., essential acids, possibly due systemic contribution impact turnover. Mass spectrometry-based qualified for risk assessment allowed us monitor response therapy. Moreover, potentially predictive pattern stratifying extent activity tissue baseline. derived otherwise hardly accessible fluid and, thus, opens up new dimension biomonitoring secondary tertiary care. simple sample collection without need trained personnel could enable decentralised long-term assess stable disease progression. indeed advance 3PM benefit online version contains supplementary material 10.1007/s13167-025-00396-6.

Language: Английский

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