Entomopathogenic Fungal Metabolites Useful in Agriculture and Healthcare

Published: Jan. 1, 2024

Language: Английский

Neurotransmitter acetylcholine mediates the mummification of Ophiocordyceps sinensis -infected Thitarodes xiaojinensis larvae

Applied and Environmental Microbiology, Journal Year: 2024, Volume and Issue: 90(9)

Published: Aug. 7, 2024

ABSTRACT Parasites can manipulate host behavior to facilitate parasite transmission. One such host–pathogen interaction occurs between the fungus Ophiocordyceps sinensis and ghost moth Thitarodes xiaojinensis. O. is involved in mummification process of infected larvae. However, underlying molecular chemical mechanism for this phenomenon unknown. We characterized small molecules regulating behaviors altered metabolites mummified Lipid-related metabolites, as phosphatidylcholine, were identified Decreased levels neurotransmitter acetylcholine (ACh) elevated choline observed brains both The aberrant activity acetylcholinesterase (AChE) relative mRNA expression ACE2 (acetylcholinesterase) may mediate transformation ACh choline, leading brain dysfunction Caspofungin treatment inhibited larvae AChE. These findings indicate importance after infection. IMPORTANCE -infected are manipulated move soil surface with their heads up death. A fruiting body then grows from caterpillar’s head, eventually producing conidia dispersal. has not been characterized. In study, we describe metabolic profile xiaojinensis Altered particularly lipid-related larvae, suggesting that lipids important -mediated behavioral manipulation brains. This suggests or reduced lead behavior. results reveal critical role

Language: Английский

Exploration of Entomopathogenic Fungi for Insect Pest Management

Published: Jan. 1, 2024

Language: Английский