International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(6), P. 3266 - 3266
Published: March 13, 2024
The
synergistic
impact
of
nanomaterials
is
critical
for
novel
intracellular
and/or
subcellular
drug
delivery
systems
minimal
toxicity.
This
synergism
results
in
a
fundamental
bio/nano
interface
interaction,
which
discussed
terms
nanoparticle
translocation,
outer
wrapping,
embedding,
and
interior
cellular
attachment.
morphology,
size,
surface
area,
ligand
chemistry
charge
nanoparticles
all
play
role
translocation.
In
this
review,
we
suggest
generalized
mechanism
to
characterize
the
interface,
as
discuss
interaction
between
cells,
tissues,
other
biological
systems.
Novel
perceptions
are
reviewed
regarding
ability
improve
hybrid
nanocarriers
with
homogeneous
structures
enhance
multifunctional
biomedical
applications,
such
bioimaging,
tissue
engineering,
immunotherapy,
phototherapy.
Sensors,
Journal Year:
2024,
Volume and Issue:
24(4), P. 1128 - 1128
Published: Feb. 8, 2024
Prostate
cancer
(PCa)
is
the
second
most
common
cancer.
In
this
paper,
isolation
and
properties
of
exosomes
as
potential
novel
liquid
biopsy
markers
for
early
PCa
diagnosis
are
investigated
using
two
prostate
human
cell
lines,
i.e.,
benign
(control)
line
RWPE1
carcinoma
22Rv1.
Exosomes
produced
by
both
lines
characterised
various
methods
including
nanoparticle-tracking
analysis,
dynamic
light
scattering,
scanning
electron
microscopy
atomic
force
microscopy.
addition,
surface
plasmon
resonance
(SPR)
used
to
study
three
different
receptors
on
exosomal
(CD63,
CD81
prostate-specific
membrane
antigen-PMSA),
implementing
monoclonal
antibodies
identifying
type
glycans
present
lectins
(glycan-recognising
proteins).
Electrochemical
analysis
understand
interfacial
exosomes.
The
results
indicate
that
cancerous
smaller,
at
higher
concentrations,
exhibit
more
nega
tive
zeta
than
control
SPR
experiments
confirm
negatively
charged
Biomaterials Research,
Journal Year:
2025,
Volume and Issue:
29
Published: Jan. 1, 2025
Tumors
grow
by
receiving
oxygen
and
nutrients
from
the
surrounding
blood
vessels,
leading
to
rapid
angiogenesis.
This
results
in
functionally
structurally
abnormal
vasculature
characterized
high
permeability
irregular
flow,
causing
hypoxia
within
tumor
microenvironment
(TME).
Hypoxia
exacerbates
secretion
of
pro-angiogenic
factors
such
as
vascular
endothelial
growth
factor
(VEGF),
further
perpetuating
vessel
formation.
environment
compromises
efficacy
radiotherapy,
immunotherapy,
chemotherapy.
In
this
study,
we
developed
a
pH-sensitive
liposome
(PSL)
system,
termed
OD_PSL@AKB,
co-deliver
(OD)
razuprotafib
(AKB-9778)
tumors.
system
rapidly
responds
acidic
TME
alleviate
inhibit
VEGF
secretion,
restoring
VE-cadherin
expression
hypoxic
cell/cancer
cell
cocultures.
Our
findings
highlight
potential
OD_PSL@AKB
normalizing
improving
therapeutic
efficacy.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(8), P. 2007 - 2018
Published: Jan. 1, 2024
Background:
drugs
for
Alzheimer's
disease
(AD)
fail
to
exhibit
efficacy
in
clinical
trials
a
number
of
reasons,
major
one
being
blood-brain
barrier
(BBB)
permeability.
Meanwhile,
the
increasing
incidence
this
emphasizes
need
effective
therapeutics.
Herein,
we
discuss
novel
nanoplatform
technologies
developed
delivery
AD
by
traversing
BBB.
Main
text:
interfacial
and
surface
chemistry
nanomaterials
is
utilized
several
industries,
including
pharmaceutical,
has
drawn
considerable
attention
field
nanotechnology.
Various
reports
have
suggested
potential
nanotechnology
treatment,
describing
unique
drug
carriers
that
improve
stability
solubility
while
maintaining
therapeutic
dosages.
These
nanotechnologies
are
harnessed
transport
across
BBB,
with
or
without
modifications.
We
also
transfer
via
nose-to-brain
pathway,
as
intranasal
enables
direct
distribution
brain.
In
addition,
nanomaterial
modifications
prolong
safety
following
administration
addressed.
Conclusion:
although
studies
yielded
promising
results,
limited
efforts
been
undertaken
translate
research
findings
into
contexts.
Nevertheless,
hold
development
solutions
against
AD.
Biosensors,
Journal Year:
2024,
Volume and Issue:
14(6), P. 307 - 307
Published: June 14, 2024
The
development
of
sensitive
and
specific
exosome
detection
tools
is
essential
because
they
are
believed
to
provide
information
that
important
for
early
detection,
screening,
diagnosis,
monitoring
cancer.
Among
the
many
tools,
surface-plasmon
resonance
(SPR)
biosensors
analytical
devices
offer
advantages
in
sensitivity
speed,
thereby
making
sample-analysis
process
faster
more
accurate.
In
addition,
penetration
depth
SPR
biosensor,
which
<300
nm,
comparable
size
exosome,
biosensor
ideal
use
research.
On
other
hand,
another
type
nanoplasmonic
sensor,
namely
a
localized
(LSPR)
has
shorter
around
6
nm.
Structural
optimization
through
addition
supporting
layers
gap
control
between
particles
needed
strengthen
field.
This
paper
summarizes
progress
LSPR
detecting
exosomes.
Techniques
signal
amplification
from
two
sensors
will
be
discussed.
There
three
main
parts
this
paper.
first
focus
on
reviewing
working
principles
each
sensor
introducing
several
methods
can
used
isolate
article
close
by
explaining
various
systems
have
been
developed
optimizations
carried
out
obtain
with
better
performance.
To
illustrate
performance
improvements
system
discussed,
parameters
highlighted
include
limit,
dynamic
range,
sensitivity.
Biosensors,
Journal Year:
2023,
Volume and Issue:
13(12), P. 1017 - 1017
Published: Dec. 6, 2023
Nanomaterials
have
gained
huge
attention
worldwide
owing
to
their
unique
physicochemical
characteristics
which
enable
applications
in
the
field
of
biomedicine
and
drug
delivery
systems.
Although
nanodrug
systems
(NDDSs)
better
target
specificity
bioavailability
than
traditional
systems,
behavior
clearance
mechanisms
living
subjects
remain
unclear.
In
this
regard,
importance
bioimaging
methods
has
come
forefront
for
investigating
biodistribution
nanocarriers
discovering
release
vivo.
review,
we
introduce
several
examples
biohybrid
nanoparticles
clinical
applications,
focusing
on
advantages
limitations.
The
various
monitoring
fate
nanodrugs
biological
future
perspectives
NDDSs
also
been
discussed.
