Gender-Specific Bile Acid Profiles in Non-Alcoholic Fatty Liver Disease DOI Open Access

Julia Fitzinger,

Giovanny Rodriguez Blanco, Markus Herrmann

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 250 - 250

Published: Jan. 13, 2024

Background: Non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. A main cause the obesogenic, so-called Western lifestyle. NAFLD follows a long, unperceived course, and ends potentially fatally. Early diagnosis of aggressive subtypes saves lives. So far, non-invasive means detection are limited. better understanding pathogenic interplay among insulin resistance, immune inflammation, microbiome, genetic background important. Metabolomics may give insight into these interlaced processes. Methods: In this study, we measured bile acids (BA) in plasma adult alcohol-associated (ALD) patients healthy controls with targeted mass spectrometry. We focused on gender-related acid production pathology ALD. Results: Compared to controls, women had significantly higher concentrations total BA, primary cholic (CA), chenodeoxycholic (CDCA), glycine-conjugated, non-12-a-OH BA. Concerning subtypes, glycocholic (GCA) glycochenodeoxycholic (GCDCA), BA were elevated NAFLD. contrast, men no altered fractions. However, GCA, glycodeoxycholic (GDCA), glycolithocholic (GLCA), lithocholic (LCA), taurolithocholic (TLCA), tauroursodeoxycholic (TUDCA) elevated, while CA was decreased. NAFLD, except ursodeoxycholic (UDC), all correlated positively both sexes ELF score, ALD, only males showed significant correlations exceptive for UDC secondary free CA, CDCA, taurine conjugated, glycine 12-a-OH, cases high enhanced fibrosis (ELF) score above 9.8. additionally elevated. Between without NASH, found differences. Conclusion: Our data show gender-specific profiles markedly different patterns Women more severe cholestasis. Men compensate fat storage-driven dynamics, indicated by levels taurine-conjugated which associate beneficial metabolic functions.

Language: Английский

Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives DOI Creative Commons
Juan Liu, Yuzhu Tan, Hao Cheng

et al.

Aging and Disease, Journal Year: 2022, Volume and Issue: 13(4), P. 1106 - 1106

Published: Jan. 1, 2022

Gut microbiota, a collection of microorganisms that live within gastrointestinal tract, provides crucial signaling metabolites for the physiological hosts. In healthy state, gut microbiota are helpful maintaining basic functions hosts, whereas disturbed production these can lead to numerous diseases such as metabolic diseases, cardiovascular neurodegenerative and cancer. Although there many reviews about specific mechanisms on is no comprehensive summarization metabolites. this Opinion, we discuss knowledge including types their ways acting targets. addition, summarize pathologic in health shaping composition nutrition. This paper be understanding roles thus provide guidance developing suitable therapeutic strategies combat microbial-driven improve health.

Language: Английский

Citations

255
Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice DOI Creative Commons
Mengci Li, Shouli Wang, Yitao Li

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: April 19, 2022

Abstract Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, gut microbiome associated with energy harvest alters dramatically in response nutrient deprivation. Here, we reported that CR high-fat diet (HFD) both remodeled microbiota similar microbial composition, Parabacteroides distasonis was most significantly decreased or HFD. altered reprogramed metabolism, resulting a distinct serum bile acid profile characterized by depleting proportion of non-12α-hydroxylated acids, ursodeoxycholic lithocholic acid. Downregulation UCP1 expression brown adipose tissue GLP-1 were observed weight-rebound mice. Moreover, treatment acids ameliorated regain via increased thermogenesis. Our results highlighted microbiota-bile crosstalk rebound gain as potential probiotic prevent rapid post-CR gain.

Language: Английский

Citations

127
Metabolic Messengers: bile acids DOI
Alessia Perino, Kristina Schoonjans

Nature Metabolism, Journal Year: 2022, Volume and Issue: 4(4), P. 416 - 423

Published: March 25, 2022

Language: Английский

Citations

126
Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis DOI Creative Commons
Junliang Kuang,

Jieyi Wang,

Yitao Li

et al.

Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(10), P. 1752 - 1766.e8

Published: Aug. 16, 2023

Non-alcoholic fatty liver disease (NAFLD) is regarded as a pandemic that affects about quarter of the global population. Recently, host-gut microbiota metabolic interactions have emerged distinct mechanistic pathways implicated in development NAFLD. Here, we report group gut microbiota-modified bile acids (BAs), hyodeoxycholic acid (HDCA) species, are negatively correlated with presence and severity HDCA treatment has been shown to alleviate NAFLD multiple mouse models by inhibiting intestinal farnesoid X receptor (FXR) upregulating hepatic CYP7B1. Additionally, significantly increased abundances probiotic species such Parabacteroides distasonis, which enhances lipid catabolism through acid-hepatic peroxisome proliferator-activated alpha (PPARα) signaling, turn upregulates FXR. These findings suggest therapeutic potential for treating NAFLD, unique mechanism simultaneously activating CYP7B1 PPARα.

Language: Английский

Citations

122
Hyocholic acid species as novel biomarkers for metabolic disorders DOI Creative Commons
Xiaojiao Zheng, Tianlu Chen, Aihua Zhao

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: March 5, 2021

Hyocholic acid (HCA) is a major bile (BA) species in the BA pool of pigs, known for its exceptional resistance to spontaneous development diabetic phenotypes. HCA and derivatives are also present human blood urine. We investigate whether profiles can predict metabolic disorders. find first cohort (n = 1107) that both obesity diabetes associated with lower serum concentrations species. A separate study 91) validates this finding further reveals individuals pre-diabetes levels feces. Serum increase patients after gastric bypass surgery 38) remission two years surgery. The results replicated independent, prospective cohorts 132 n 207), where found be strong predictors disorders 5 10 years, respectively. These findings underscore association diabetes, demonstrate feasibility using assess future risk developing abnormalities.

Language: Английский

Citations

110
Interactive Relationships between Intestinal Flora and Bile Acids DOI Open Access

Xiaohua Guo,

Edozie Samuel Okpara,

Wanting Hu

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(15), P. 8343 - 8343

Published: July 28, 2022

The digestive tract is replete with complex and diverse microbial communities that are important for the regulation of multiple pathophysiological processes in humans animals, particularly those involved maintenance intestinal homeostasis, immunity, inflammation, tumorigenesis. diversity bile acids a result joint efforts host microflora. There bidirectional relationship between community that, while flora tightly modulates metabolism synthesis acids, acid pool composition affect homeostasis flora. Homeostatic imbalances systems may lead to development variety diseases, such as inflammatory bowel disease (IBD), colorectal cancer (CRC), hepatocellular carcinoma (HCC), type 2 diabetes (T2DM), polycystic ovary syndrome (PCOS). interactions be (in)directly pathogenesis these diseases.

Language: Английский

Citations

95
Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis DOI
Jia Wang, Yitao Li, Kenneth Cheung

et al.

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 67(5), P. 865 - 878

Published: July 27, 2023

Language: Английский

Citations

67
Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity DOI Creative Commons

Mingliang Zhao,

Zhenxing Ren, Aihua Zhao

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(5), P. 1000 - 1012.e6

Published: April 5, 2024

The gut-brain axis is implicated in depression development, yet its underlying mechanism remains unclear. We observed depleted gut bacterial species, including Bifidobacterium longum and Roseburia intestinalis, the neurotransmitter homovanillic acid (HVA) individuals with mouse models. Although R. intestinalis does not directly produce HVA, it enhances B. abundance, leading to HVA generation. This highlights a synergistic interaction among microbiota regulating intestinal production. Administering longum, or models chronic unpredictable mild stress (CUMS) corticosterone (CORT)-induced significantly improved depressive symptoms. Mechanistically, inhibited synaptic autophagic death by preventing excessive degradation of microtubule-associated protein 1 light chain 3 (LC3) SQSTM1/p62 proteins, protecting hippocampal neurons' presynaptic membrane. These findings underscore role microbial metabolism modulating integrity provide insights into potential novel treatment strategies for depression.

Language: Английский

Citations

32
Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner DOI Creative Commons
Jianqing She, Gulinigaer Tuerhongjiang,

Manyun Guo

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(2), P. 408 - 421.e5

Published: Feb. 1, 2024

Language: Английский

Citations

24
Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review DOI Creative Commons
Hongcai Li, Jingjing Liang, Mengzhen Han

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: March 1, 2024

Non-alcoholic fatty liver disease (NAFLD) is a common chronic with an increasing incidence worldwide. Single drug therapy may have toxic side effects and disrupt gut microbiota balance. Polyphenols are widely used in intervention due to their distinctive nutritional properties medicinal value, which potential modulator. However, there lack of comprehensive review explore the efficacy mechanism combined drugs polyphenols for NAFLD. Based on this, this firstly discusses link between NAFLD microbiota, outlines microbiota. Secondly, it examined recent advances treatment therapeutic effect combination two. Finally, we highlight underlying mechanisms polyphenol This mainly terms signaling pathways (NF-κB, AMPK, Nrf2, JAK/STAT, PPAR, SREBP-1c, PI3K/Akt TLR) Furthermore, some emerging such as microRNA biomarker therapies provide avenues Drawing inspiration from strategies, use active substances holds transformative prospective potential, both improve restore balance while reducing required dosage. systematically bidirectional interactions NAFLD, summarizes synergistic by modulating Future researches should develop multi-omics technology identify patients who benefit devising individualized plans enhance its effect.

Language: Английский

Citations

19