Association between stress hyperglycemia ratio and neovascular glaucoma in patients with proliferative diabetic retinopathy DOI Creative Commons

Chuankai Fang,

Di He,

Minghai Shen

et al.

BMC Ophthalmology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 1, 2025

The purpose of this study was to investigate the association between stress hyperglycemia ratio (SHR) and occurrence neovascular glaucoma (NVG) in patients with proliferative diabetic retinopathy (PDR). We aimed explore potential role SHR as a biomarker for NVG risk identify demographic clinical modifiers association. conducted retrospective cohort using electronic health records from our hospital over 10-year period 2010 2020. Patients diagnosed PDR were included, exclusions those without diabetes-related or incomplete data. calculated admission blood glucose HbA1c levels. Logistic regression Cox proportional hazards modeling used assess NVG, adjusting confounders. A total 1,245 identified, which 378 (30.3%) had NVG. mean entire 2.9, higher observed group (3.2 vs. 2.7, p < 0.001). Multivariate logistic analysis revealed significant (OR 2.5, 95% CI 1.9 3.3, Subgroup showed stronger males (HR 1.4, 1.1 1.7, = 0.01) 65 years old 1.5, 1.2 1.9, also more pronounced diabetes duration exceeding 15 1.8, 0.01). Our demonstrated patients, certain subgroups showing These findings suggest that glycemic variability, measured by SHR, may play critical development could inform tailored strategies prevention management high-risk patients.

Language: Английский

Integrated Genomics and Multi-OMICS in Precision and Personalised Medicine: Emerging New Paradigm for Clinical Medicine DOI Creative Commons
Dhavendra Kumar

Apollo Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Genomics is one of core components very basic biological processes transcription, translation and peptide molecule synthesis, collectively known as the ‘central dogma life’. This basis multitude sciences with OMICS suffix, for example, transcriptomics, proteomics, metabolomics others. Almost all OMIC have direct or indirect bearing on many interrelated relevant to integrated molecular pathways systems body organs functioning tissues. The concept multi-OMICS medicine now supported by recurrent outcomes fundamental applied life research. common purpose deliver healthcare precisely possible targeted at specific points in an individual patient thus satisfying requirement personalised medicine. There growing interest evidence integrate traditional ancient like Ayurveda. review provides factual information context evidence-based, ethically sound, precision

Language: Английский

Citations

0
Association between stress hyperglycemia ratio and neovascular glaucoma in patients with proliferative diabetic retinopathy DOI Creative Commons

Chuankai Fang,

Di He,

Minghai Shen

et al.

BMC Ophthalmology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 1, 2025

The purpose of this study was to investigate the association between stress hyperglycemia ratio (SHR) and occurrence neovascular glaucoma (NVG) in patients with proliferative diabetic retinopathy (PDR). We aimed explore potential role SHR as a biomarker for NVG risk identify demographic clinical modifiers association. conducted retrospective cohort using electronic health records from our hospital over 10-year period 2010 2020. Patients diagnosed PDR were included, exclusions those without diabetes-related or incomplete data. calculated admission blood glucose HbA1c levels. Logistic regression Cox proportional hazards modeling used assess NVG, adjusting confounders. A total 1,245 identified, which 378 (30.3%) had NVG. mean entire 2.9, higher observed group (3.2 vs. 2.7, p < 0.001). Multivariate logistic analysis revealed significant (OR 2.5, 95% CI 1.9 3.3, Subgroup showed stronger males (HR 1.4, 1.1 1.7, = 0.01) 65 years old 1.5, 1.2 1.9, also more pronounced diabetes duration exceeding 15 1.8, 0.01). Our demonstrated patients, certain subgroups showing These findings suggest that glycemic variability, measured by SHR, may play critical development could inform tailored strategies prevention management high-risk patients.

Language: Английский

Citations

0