Physiology & Behavior, Journal Year: 2023, Volume and Issue: 268, P. 114236 - 114236
Published: May 12, 2023
Language: Английский
Science, Journal Year: 2020, Volume and Issue: 368(6487), P. 197 - 201
Published: April 9, 2020
More than a normal neurotransmitter The molecular mechanisms underlying the persistence of addiction remain largely unclear. Lepack et al. found that, with cocaine exposure, there is an intracellular accumulation dopamine in neurons brain region called ventral tegmental area (see Perspective by Girault). Dopamine associates chromatin to initiate previously unknown form epigenetic regulation dopaminylation. This modification has impact on function and, consequently, dopaminergic action potentials. result aberrant signaling striatum during periods drug seeking. Science , this issue p. 197 ; see also 134
Language: Английский
Citations
199
Biological Psychiatry, Journal Year: 2019, Volume and Issue: 87(1), P. 64 - 73
Published: Dec. 2, 2019
Language: Английский
Citations
182
Clinical Psychology Review, Journal Year: 2021, Volume and Issue: 86, P. 102007 - 102007
Published: March 27, 2021
Language: Английский
Citations
170
Frontiers in Aging Neuroscience, Journal Year: 2021, Volume and Issue: 13
Published: July 13, 2021
The elderly population is growing worldwide, with important health and socioeconomic implications. Clinical experimental studies on aging have uncovered numerous changes in the brain, such as decreased neurogenesis, increased synaptic defects, greater metabolic stress, enhanced inflammation. These are associated cognitive decline neurobehavioral deficits. Although not a disease, it significant risk factor for functional worsening, affective impairment, disease exaggeration, dementia, general susceptibility. Conversely, life events related to mental stress trauma can also lead accelerated age-associated disorders dementia. Here, we review human mice rats, those modeling neurodegenerative diseases, that helped elucidate (1) dynamics mechanisms underlying biological pathological of main projecting systems brain (glutamatergic, cholinergic, dopaminergic) (2) effect defective glutamatergic, dopaminergic projection disabilities disorders, Alzheimer’s Parkinson’s diseases. Detailed knowledge age-related diseases be an element development effective ways treatment. In this context, briefly analyze which adverse glutaminergic could targeted by therapeutic strategies developed result our better understanding these damaging mechanisms.
Language: Английский
Citations
118
Frontiers in Pharmacology, Journal Year: 2018, Volume and Issue: 8
Published: Jan. 10, 2018
TAAR1 is widely expressed across the mammalian brain, particularly in limbic and monoaminergic areas, allegedly involved mood, attention, memory, fear, addiction. However, subcellular distribution of still unclear, since signal largely intracellular. In vitro, activated with nanomolar to micromolar affinity by some endogenous amines, p-tyramine, beta-phenylethylamine, 3-iodothyronamine (T1AM), latter representing a novel branch thyroid hormone signaling. addition, responds number psychoactive drugs, i.e. amphetamines, ergoline derivatives, bromocriptine lisuride. Trace amines have been identified as neurotransmitters invertebrates, they are considered potential neuromodulators. particular, beta-phenylethylamine p-tyramine reported modify release and/or response dopamine, norepinephrine, acetylcholine GABA, while evidence cross-talk between other aminergic receptors has provided. Systemic or intracerebroventricular injection exogenous T1AM produced prolearning antiamnestic effects, reduced pain threshold, decreased non-REM sleep, modulated firing rate adrenergic neurons locus coeruleus. However each these substances may additional molecular targets, it unclear whether their levels sufficient produce significant activation vivo. knock out mice show worse performance anxiety working memory tests, more prone develop ethanol The also increased locomotor amphetamine, stereotypical responses induced apomorphine. Notably, human genes for TAARs cluster on chromosome 6 at q23, within region whose mutations confer susceptibility schizophrenia bipolar disorder. For TAAR1, around 200 non-synonymous 400 synonymous single nucleotide polymorphisms identified, but functional consequences not extensively investigated yet. conclusion, bulk points physiological role modulation central nervous system function pharmacological agonists neurology psychiatry. specific effects stimulation controversial, many crucial issues require further investigation.
Language: Английский
Citations
140
International Journal of Bipolar Disorders, Journal Year: 2017, Volume and Issue: 5(1)
Published: Sept. 22, 2017
Bipolar disorder is characterized by recurrent manic and depressive episodes. Patients suffering from this experience dramatic mood swings with a wide variety of typical behavioral facets, affecting overall activity, energy, sexual behavior, sense self, self-esteem, circadian rhythm, cognition, increased risk for suicide. Effective treatment options are limited diagnosis can be complicated. To overcome these obstacles, better understanding the neurobiology underlying bipolar needed. Animal models useful tools in brain mechanisms associated certain behavior. The following review discusses several pathological aspects humans compares findings insights obtained animal mimicking diverse facets its symptomatology. Various sections concentrate on specific topics that relevant human patients, namely rhythms, neurotransmitters, focusing dopaminergic system, stressful environment, immune system. We then explain how areas have been manipulated to create disorder. Even though approaches conducted, there still lack adequate Specifically, most mimic only mania or depression few include cyclical nature condition. Future studies could therefore focus modeling both episodes same model also possibility investigate switch mania-like behavior depressive-like vice versa. use viral rhythms system might make creation such possible.
Language: Английский
Citations
100
Frontiers in Neural Circuits, Journal Year: 2020, Volume and Issue: 14
Published: June 30, 2020
The comorbidity of depression and addiction has become a serious public health issue, the relationship between these two disorders their potential mechanisms attracted extensive attention. Numerous studies have suggested that share common anatomical pathways. nucleus accumbens (NAc) long been considered key brain region for regulating many behaviors, especially those related to addiction. In this review, we focus on association depression, highlighting mediating role NAc in via regulation changes neural circuits molecular signaling. To clarify underlying association, summarize evidence from overlapping reward neurocircuitry, resemblance cellular mechanisms, treatments. Understanding interplay should help guide clinical prevention search new target treatment.
Language: Английский
Citations
85
Biological Psychiatry, Journal Year: 2019, Volume and Issue: 87(3), P. 204 - 214
Published: Oct. 3, 2019
Language: Английский
Citations
79
Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(6), P. 1912 - 1924
Published: Feb. 2, 2024
Language: Английский
Citations
17
Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: April 2, 2024
The nucleus accumbens (NAc) is a key node of the brain reward circuit driving reward-related behavior. Dysregulation NAc has been demonstrated to contribute pathological markers addiction in substance use disorder (SUD) making it potential therapeutic target for stimulation. Transcranial focused ultrasound (tFUS) an emerging non-invasive stimulation approach that can modulate deep regions with high spatial resolution. However, there currently no evidence showing how activity and functional connectivity within network neuromodulated by tFUS on NAc.
Language: Английский
Citations
13