Nutrients,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1620 - 1620
Published: March 27, 2023
Autism
spectrum
disorder
(ASD)
is
a
complex
neurodevelopmental
with
multifactorial
etiology,
characterized
by
impairment
in
two
main
functional
areas:
(1)
communication
and
social
interactions,
(2)
skills,
interests
activities.
ASD
patients
often
suffer
from
gastrointestinal
symptoms
associated
dysbiotic
states
“leaky
gut.”
A
key
role
the
pathogenesis
of
has
been
attributed
to
gut
microbiota,
as
it
influences
central
nervous
system
development
neuropsychological
homeostasis
through
microbiota–gut–brain
axis.
state
dysbiosis
reduction
Bacteroidetes/Firmicutes
ratio
Bacteroidetes
level
other
imbalances
common
ASD.
In
recent
decades,
many
authors
have
tried
study
identify
microbial
signature
vivo
ex
studies.
this
regard,
advent
metabolomics
also
great
help.
Based
on
these
data,
several
therapeutic
strategies,
primarily
use
probiotics,
are
investigated
improve
modulation
microbiota.
However,
although
results
promising,
heterogeneity
studies
precludes
concrete
evidence.
The
aim
review
explore
intestinal
barrier
dysfunction,
gut–brain
axis
microbiota
alterations
possible
probiotic
supplementation
patients.
Molecular Psychiatry,
Journal Year:
2023,
Volume and Issue:
28(7), P. 2645 - 2673
Published: Jan. 27, 2023
Abstract
Bipolar
disorders
(BD)
represent
a
severe
leading
disabling
mental
condition
worldwide
characterized
by
episodic
and
often
progressive
mood
fluctuations
with
manic
depressive
stages.
The
biological
mechanisms
underlying
the
pathophysiology
of
BD
remain
incompletely
understood,
but
it
seems
that
there
is
complex
picture
genetic
environmental
factors
implicated.
Nowadays,
gut
microbiota
in
spotlight
new
research
related
to
this
kind
psychiatric
disorder,
as
can
be
consistently
several
pathophysiological
events
observed
BD.
In
context
so-called
microbiota–gut–brain
(MGB)
axis,
shown
have
strong
influence
on
host
neuromodulation
endocrine
functions
(i.e.,
controlling
synthesis
neurotransmitters
like
serotonin
or
mediating
activation
hypothalamic–pituitary–adrenal
axis),
well
modulation
immune
responses,
critically
regulating
intestinal,
systemic
brain
inflammation
(neuroinflammation).
present
review
aims
elucidate
derived
from
MGB
axis
disruption
possible
therapeutic
approaches
mainly
focusing
network
Understanding
its
bidirectional
communication
other
systems
shed
light
discovery
therapies
for
improving
clinical
management
these
patients.
Besides,
effect
drugs
currently
used
patients,
together
therapeutical
targeting
ecosystem
(dietary
patterns,
probiotics,
prebiotics,
novelties)
will
also
contemplated.
Acta Diabetologica,
Journal Year:
2023,
Volume and Issue:
60(8), P. 1007 - 1017
Published: April 14, 2023
Abstract
Aims
The
purpose
of
this
review
is
to
explore
the
interconnected
pathways
microbiota-gut-brain
axis
(MGBA),
focusing
on
roles
vagus
nerve
and
glucagon
like
peptide-1
in
appetite
control,
development
obesity
diabetes.
Methods
Type
2
diabetes
mellitus
(T2DM)
are
metabolic
disorders
whose
prevalence
has
significantly
increased
recent
decades
expected
increase
every
year,
pandemic
proportions.
These
two
pathologies
often
coexist
have
substantial
public
health
implications.
term
“diabesity”
defines
pathophysiological
connection
between
overweight
T2DM.
gut
microbiota
affects
many
aspects
host.
Beyond
regulation
intestinal
functions
activation
immune
responses,
plays
a
role
central
nervous
system
(i.e.,
mood,
psychiatric
conditions
associated
with
stress
memory)
regulator
metabolism
appetite.
Results
MGBA
involves
such
as
autonomic
enteric
systems,
hypothalamic–
pituitary–adrenal
axis,
system,
enteroendocrine
cells,
microbial
metabolites.
Notably,
an
essential
eating
behavior
by
modulating
learning
nutritional
preferences.
Conclusions
Because
its
cell-mediated
interaction
microbiota,
may
provide
potential
pathway
through
which
microorganisms
influence
host
feeding
control
physiological
pathological
conditions.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(11), P. 9577 - 9577
Published: May 31, 2023
The
human
gut
microbiome
contains
the
largest
number
of
bacteria
in
body
and
has
potential
to
greatly
influence
metabolism,
not
only
locally
but
also
systemically.
There
is
an
established
link
between
a
healthy,
balanced,
diverse
overall
health.
When
becomes
unbalanced
(dysbiosis)
through
dietary
changes,
medication
use,
lifestyle
choices,
environmental
factors,
ageing,
this
profound
effect
on
our
health
linked
many
diseases,
including
metabolic
inflammatory
neurological
diseases.
While
humans
largely
association
dysbiosis
with
disease,
animal
models,
causative
can
be
demonstrated.
brain
particularly
important
maintaining
health,
strong
neurodegenerative
neurodevelopmental
This
suggests
that
microbiota
composition
used
make
early
diagnosis
diseases
modifying
microbiome-gut-brain
axis
might
present
therapeutic
target
for
have
proved
intractable,
aim
altering
trajectory
such
as
Alzheimer's
Parkinson's
multiple
sclerosis,
autism
spectrum
disorder,
attention-deficit
hyperactivity
among
others.
other
potentially
reversible
migraine,
post-operative
cognitive
dysfunction,
long
COVID,
which
considered
models
therapy
disease.
role
traditional
methods
microbiome,
well
newer,
more
novel
treatments
faecal
transplants
photobiomodulation,
are
discussed.
Biology of Sex Differences,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Feb. 7, 2023
Metabolic
diseases,
such
as
obesity,
metabolic
syndrome
(MetS)
and
type
2
diabetes
(T2D),
are
now
a
widespread
pandemic
in
the
developed
world.
These
pathologies
show
sex
differences
their
development
prevalence,
steroids,
mainly
estrogen
testosterone,
thought
to
play
prominent
role
this
sexual
dimorphism.
The
influence
of
hormones
on
these
is
not
only
reflected
between
men
women,
but
also
women
themselves,
depending
hormonal
changes
associated
with
menopause.
observed
gut
microbiota
composition
have
led
multiple
studies
highlighting
interaction
steroid
its
ultimately
pointing
new
therapy
for
diseases
based
manipulation
microbiota.
This
review
aims
shed
light
prevalence
focusing
MetS
T2D.
We
focus
microbiota,
particular
aspects
barrier
integrity,
inflammatory
status,
gut-brain
axis,
given
relevance
factors
diseases.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1620 - 1620
Published: March 27, 2023
Autism
spectrum
disorder
(ASD)
is
a
complex
neurodevelopmental
with
multifactorial
etiology,
characterized
by
impairment
in
two
main
functional
areas:
(1)
communication
and
social
interactions,
(2)
skills,
interests
activities.
ASD
patients
often
suffer
from
gastrointestinal
symptoms
associated
dysbiotic
states
“leaky
gut.”
A
key
role
the
pathogenesis
of
has
been
attributed
to
gut
microbiota,
as
it
influences
central
nervous
system
development
neuropsychological
homeostasis
through
microbiota–gut–brain
axis.
state
dysbiosis
reduction
Bacteroidetes/Firmicutes
ratio
Bacteroidetes
level
other
imbalances
common
ASD.
In
recent
decades,
many
authors
have
tried
study
identify
microbial
signature
vivo
ex
studies.
this
regard,
advent
metabolomics
also
great
help.
Based
on
these
data,
several
therapeutic
strategies,
primarily
use
probiotics,
are
investigated
improve
modulation
microbiota.
However,
although
results
promising,
heterogeneity
studies
precludes
concrete
evidence.
The
aim
review
explore
intestinal
barrier
dysfunction,
gut–brain
axis
microbiota
alterations
possible
probiotic
supplementation
patients.
