Microbiota gut-brain axis: implications for pediatric-onset leukodystrophies DOI Creative Commons
Ylenia Vaia,

Fabio Bruschi,

Veronica Maria Tagi

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: July 12, 2024

Neurodegenerative disorders are a group of diseases characterized by progressive degeneration the nervous system, leading to gradual loss previously acquired motor, sensory and/or cognitive functions. Leukodystrophies amongst most frequent childhood-onset neurodegenerative and primarily affect white matter brain, often resulting in neuro-motor disability. Notably, gastrointestinal (GI) symptoms complications, such as gastroesophageal reflux disease (GERD) dysphagia, significantly impact patients’ quality life, highlighting need for comprehensive management strategies. Gut dysbiosis, microbial imbalance, has been implicated various GI diseases. This narrative review explores intricate relationship between symptoms, Microbiota (GM), neurodegeneration. Emerging evidence underscores profound influence GM on neurological functions via microbiota gut-brain axis. Animal models have demonstrated alterations composition associated with neuroinflammation Our single-centre experience reveals high prevalence leukodystrophy population, emphasizing importance gastroenterological assessment nutritional intervention affected children. The bidirectional neurodegeneration suggests potential role gut dysbiosis progression. Prospective studies investigating leukodystrophies essential understand axis dysfunction progression identify novel therapeutic targets. In conclusion, elucidating interplay disorders, GM, holds promise precision treatments aimed at improving patient outcomes life.

Language: Английский

Current understanding of the Alzheimer’s disease-associated microbiome and therapeutic strategies DOI Creative Commons
Dong-oh Seo, David M. Holtzman

Experimental & Molecular Medicine, Journal Year: 2024, Volume and Issue: 56(1), P. 86 - 94

Published: Jan. 4, 2024

Abstract Alzheimer’s disease (AD) is a fatal progressive neurodegenerative disease. Despite tremendous research efforts to understand this complex disease, the exact pathophysiology of not completely clear. Recently, anti-Aβ antibodies have been shown remove amyloid from brain and slow clinical progression mild dementia by ~30%. However, exploring alternative strategies crucial understanding developing more effective therapeutic interventions. In recent years, microbiota-gut-brain axis has received significant attention in AD field. Numerous studies suggested that alterations gut microbiota composition are associated with AD, several underlying mechanisms proposed. area still their infancy, many aspects field just beginning be explored understood. Gaining deeper intricate interactions signaling pathways involved microbiota-AD interaction for optimizing targeting positively impact AD. review, we aim summarize current We will discuss existing evidence regarding role pathogenesis, mechanisms, biological factors influencing microbiome-gut-brain remaining questions Last, potential approaches recondition community alleviate progression. An ongoing exploration gut-brain development microbiota-based therapies hold advancing management future.

Language: Английский

Citations

87
Health equity, care access and quality in headache – part 1 DOI Creative Commons
Claudio Tana, Bianca Raffaelli, Marcio Nattan Portes Souza

et al.

The Journal of Headache and Pain, Journal Year: 2024, Volume and Issue: 25(1)

Published: Jan. 29, 2024

Abstract Current definitions of migraine that are based mainly on clinical characteristics do not account for other patient’s features such as those related to an impaired quality life, due loss social life and productivity, the differences geographical distribution disease cultural misconceptions which tend underestimate a psychosocial rather than neurobiological disorder. Global definition, care access, health equity headache disorders, especially reported in this paper from collaborative group editorial board members Journal Headache Pain. Other components affect patients with migraine, addition impact promoted by symptoms stigma determinants, also reported.

Language: Английский

Citations

33
Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis DOI Creative Commons
Najeeha Talat Iqbal,

Hana Khan,

Aqsa Khalid

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: Jan. 23, 2025

Language: Английский

Citations

3
Photobiomodulation for Neurodegenerative Diseases: A Scoping Review DOI Open Access
Qi Shen,

Haoyun Guo,

Yihua Yan

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1625 - 1625

Published: Jan. 28, 2024

Neurodegenerative diseases involve the progressive dysfunction and loss of neurons in central nervous system thus present a significant challenge due to absence effective therapies for halting or reversing their progression. Based on characteristics neurodegenerative such as Alzheimer’s disease (AD) Parkinson’s (PD), which have prolonged incubation periods protracted courses, exploring non-invasive physical therapy methods is essential alleviating ensuring that patients an improved quality life. Photobiomodulation (PBM) uses red infrared light therapeutic benefits functions by stimulating, healing, regenerating, protecting organizations at risk injury, degradation, death. Over last two decades, PBM has gained widespread recognition method, showing efficacy pain relief, anti-inflammatory responses, tissue regeneration. Its application expanded into fields neurology psychiatry, where extensive research been conducted. This paper presents review evaluation studies investigating diseases, with specific emphasis recent applications AD PD treatment both animal human subjects. Molecular mechanisms related neuron damage cognitive impairment are scrutinized, offering valuable insights PBM’s potential strategy.

Language: Английский

Citations

14
Parkinson’s Disease and Photobiomodulation: Potential for Treatment DOI Open Access
Brian Bicknell, Ann Liebert, Geoffrey Herkes

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(1), P. 112 - 112

Published: Jan. 19, 2024

Parkinson’s disease is the second most common neurodegenerative and increasing in incidence. The combination of motor non-motor symptoms makes this a devastating for people with their care givers. characterised by mitochondrial dysfunction neuronal death substantia nigra, reduction dopamine, accumulation α-synuclein aggregates neuroinflammation. microbiome–gut–brain axis also important disease, involved spread inflammation aggregated α-synuclein. mainstay treatment dopamine replacement therapy, which can reduce some signs. There need additional options to supplement available medications. Photobiomodulation (PBM) form light therapy that has been shown have multiple clinical benefits due its enhancement electron transport chain subsequent increase membrane potential ATP production. PBM modulates cellular signalling inflammation. Clinically, used decades improve wound healing, treat pain, swelling heal deep tissues. Pre-clinical experiments indicated signs provide neuroprotection. This effect seen whether directed head animal or other parts body (remotely). A small number trials given weight possibility using both may potentially slow progression.

Language: Английский

Citations

13
Migraine Comorbidities DOI Creative Commons
Dan Iulian Cuciureanu, Cătălina Elena Bistriceanu,

Georgiana-Anca Vulpoi

et al.

Life, Journal Year: 2024, Volume and Issue: 14(1), P. 74 - 74

Published: Jan. 2, 2024

Novel knowledge about the interrelationships and reciprocal effects of migraine epilepsy, mood disorders, or irritable bowel syndrome has emerged in recent decades. Over time, comorbid pathologies associated with that share common physiopathological mechanisms were studied. Among these studied is a disorder ion channel dysfunctions as well glutamatergic transmission. A high degree neuronal excitement abnormalities are epilepsy antiepileptic drugs useful treating both disorders. The coexistence may occur independently same individual two be causally connected. relationship between cortical spreading depression (CSD) epileptic foci been suggested by basic clinical neuroscience research. most relevant psychiatric comorbidities anxiety which influence its course, treatment response, outcome. association major depressive can explained robust molecular genetic background. In addition to role potent vasodilator, CGRP also involved transmission nociception, phenomenon inevitably linked stress caused frequent attacks. Another aspect gut microbiome migraine’s pathology gut–brain axis involvement. Irritable patients more likely suffer migraines, according other studies. There no precise explanation for how microbiota contributes neurological disorders general migraines particular. This study aims show conditions, such microbiota, connected from bench bedside. It conditions pathophysiological will have significant impact on best choices provide clues future options.

Language: Английский

Citations

12
Probiotics and the microbiota-gut-brain axis in neurodegeneration: Beneficial effects and mechanistic insights DOI
Fatemeh Taghizadeh Ghassab,

Fatemeh Shamlou Mahmoudi,

Reyhaneh Taheri Tinjani

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 350, P. 122748 - 122748

Published: June 5, 2024

Language: Английский

Citations

10
Dynamic changes in the gut microbiota play a critical role in age-associated cognitive dysfunction via SCFAs and LPS synthesis metabolic pathways during brain aging DOI

Xiaoying Ma,

Jiaying Liu, Lei Jiang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140945 - 140945

Published: Feb. 11, 2025

Language: Английский

Citations

2
Could a Mediterranean Diet Modulate Alzheimer’s Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1559 - 1559

Published: April 29, 2025

Neurodegenerative disorders such as Alzheimer's disease (AD), the most common form of dementia, represent a growing global health crisis, yet current treatment strategies remain primarily palliative. Recent studies have shown that neurodegeneration through complex interactions within gut-brain axis largely depends on gut microbiota and its metabolites. This review explores intricate molecular mechanisms linking dysbiosis to cognitive decline, emphasizing impact microbial metabolites, including short-chain fatty acids (SCFAs), bile acids, tryptophan neuroinflammation, blood-brain barrier (BBB) integrity, amyloid-β tau pathology. The paper highlights major microbiome signatures associated with disease, detailing their metabolic pathways inflammatory crosstalk. Dietary interventions promise in modulating composition, potentially mitigating neurodegenerative processes. critically examines influence dietary patterns, Mediterranean Western diets, microbiota-mediated neuroprotection. Bioactive compounds like prebiotics, omega-3 polyphenols exhibit neuroprotective effects by reducing neuroinflammation. Furthermore, it discusses emerging microbiome-based therapeutic strategies, probiotics, postbiotics, fecal transplantation (FMT), potential for slowing progression. Despite these advances, several knowledge gaps remain, interindividual variability responses need large-scale, longitudinal studies. study proposes an integrative, precision medicine approach, incorporating science into paradigms. Ultimately, cognizance at mechanistic level could unlock novel avenues, offering non-invasive, diet-based strategy managing improving health.

Language: Английский

Citations

2
Migraine as a Disease Associated with Dysbiosis and Possible Therapy with Fecal Microbiota Transplantation DOI Creative Commons

Ágnes Kappéter,

Dávid Sipos,

Adorján Varga

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(8), P. 2083 - 2083

Published: Aug. 14, 2023

Migraine is a painful neurological condition characterized by severe pain on one or both sides of the head. It may be linked to changes in gut microbiota, which are influenced antibiotic use and other factors. Dysbiosis, develops persists as result earlier therapy, composition intestinal flora, can lead development various diseases such metabolic disorders, obesity, hematological malignancies, behavioral migraine. Metabolites produced microbiome have been shown influence gut–brain axis. The probiotics dietary supplement reduce number severity migraine episodes. Dietary strategies affect course migraines valuable tool for improving management. With fecal microbiota transplantation, microbial restoration more effective durable. Changes after transplantation were studied detail, many data help us interpret successful interventions. microbiological alteration microflora normalization inflammatory mediators, serotonin pathway, frequency intensity pain.

Language: Английский

Citations

19