Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123021 - 123021
Published: Dec. 15, 2024
Language: Английский
Expert Opinion on Drug Delivery, Journal Year: 2023, Volume and Issue: 20(12), P. 1713 - 1730
Published: Aug. 5, 2023
A major challenge in treating central nervous system (CNS) disorders is to achieve adequate drug delivery across the blood-brain barrier (BBB). Receptor-mediated nanodrug as a Trojan horse strategy has become an exciting approach. However, these nanodrugs do not accumulate significantly brain parenchyma, which greatly limits therapeutic effect of drugs. Amplifying efficiency receptor-mediated BBB becomes holy grail treatment CNS disorders.
Language: Английский
Citations
23
JACS Au, Journal Year: 2025, Volume and Issue: 5(3), P. 1157 - 1172
Published: Feb. 20, 2025
There has been much controversy about whether the well-known alkaloid and tertiary amine base cocaine (pKa = 8.5) binds to human dopamine transporter (DAT) in its protonated form. Most potent DAT inhibitors are also strong amines─yet there some noteworthy examples where neutral analogues have high affinity, while quaternary ammonium analog of cocaine, methiodide, is a comparatively poor inhibitor. In this paper, we show that fluorescent analog, with lower pKa than becomes binding site conclude similar behavior must be expected from cocaine. By determining aspartate residue believed interact able explain apparently contradictory structure–activity data analogues.
Language: Английский
Citations
1
European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2022, Volume and Issue: 181, P. 249 - 262
Published: Nov. 11, 2022
Language: Английский
Citations
32
Heliyon, Journal Year: 2022, Volume and Issue: 8(6), P. e09575 - e09575
Published: June 1, 2022
The function of the brain can be affected by various factors that include infection, tumor, and stroke. major disorders reported with altered are Alzheimer's disease (AD), Parkinson's (PD), dementia, cancer, seizures, mental disorders, other movement disorders. barrier in treating CNS is blood-brain (BBB), which protects from toxic molecules, cerebrospinal fluid (CSF) barrier, separates blood CSF. Brain endothelial cells perivascular elements provide an integrated cellular BBB, hamper invasion molecules to brain. Even though many drugs available treat neurological it fails reach desired site required concentration. In this purview, liposomes carry concentrations intracellular diverse routes such as carrier-mediated transport receptor-mediated transcytosis. Surface modification enables them deliver cells, including neurons, astrocytes, oligodendrocytes, microglia. research studies supported role delivering across BBB reducing pathogenesis AD PD. were surface-functionalized intricated or PD pathogenesis. targeted sustained delivery disturbed due antibody formation, renal clearance, accelerated complement activation-related pseudoallergy (CARPA). Hence, review will focus on characteristics, surface functionalization, drug loading, biodistribution respective addition, alternative strategies overcome immunogenicity discussed briefly.
Language: Английский
Citations
31
Nanomedicine, Journal Year: 2023, Volume and Issue: 18(2), P. 125 - 143
Published: Jan. 1, 2023
Because of the blood-brain barrier, only a limited fraction drugs can penetrate brain. As result, there is need to take larger doses drug, which may result in numerous undesirable side effects. Over past few decades, plethora research has been conducted address this issue. In recent years, field nanomedicine reported promising findings. Currently, types polylactic-co-glycolic acid-based drug-delivery systems are being studied, and great progress made modification their surfaces with variety ligands. review, authors highlight preparation nanoparticles single- dual-targeted peptide modifications for site-specific drug delivery into brain.The blood–brain barrier prevents many used treat brain diseases from having clinical To solve issue, some findings have research, will be introduced article as possible effective methods treatment diseases. This review focus on nature acid polymers involved desired targeted nanocarriers, synthesis achieving loaded system choice targeting agents.
Language: Английский
Citations
18
Molecules, Journal Year: 2024, Volume and Issue: 29(11), P. 2627 - 2627
Published: June 3, 2024
Despite several decades of research, the beneficial effect flavonoids on health is still enigmatic. Here, we focus antioxidant flavonoids, which elementary to their biological activity. A relatively new strategy for obtaining a more accurate understanding this leverage computational chemistry. This review systematically presents various chemistry indicators employed over past five years investigate activity flavonoids. We categorize these strategies into aspects: electronic structure analysis, thermodynamic kinetic interaction and bioavailability analysis. The principles, characteristics, limitations methods are discussed, along with current trends.
Language: Английский
Citations
6
Diabetes Metabolic Syndrome and Obesity, Journal Year: 2024, Volume and Issue: Volume 17, P. 343 - 362
Published: Jan. 1, 2024
Abstract: Diabetes mellitus (DM) is a chronic metabolic disease characterized by elevated blood glucose levels, resulting in multi-organ dysfunction and various complications. Fusion proteins can form multifunctional complexes combining the target with partner proteins. It has significant advantages improving performance of proteins, extending their biological half-life, enhancing patient drug compliance. protein-based drugs have emerged as promising new diabetes therapeutics. However, there not been systematic review fusion for Hence, we conducted comprehensive published literature on diabetic diabetes, primary focus immunoglobulin G (IgG) fragment crystallizable (Fc) region, albumin, transferrin (TF). This aims to provide reference subsequent development clinical application Keywords: mellitus, protein, Fc glucagon-like peptide 1 receptor agonists, transferrin, albumin
Language: Английский
Citations
4
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125299 - 125299
Published: Jan. 1, 2025
Language: Английский
Citations
0
Neurotoxicity Research, Journal Year: 2025, Volume and Issue: 43(2)
Published: March 28, 2025
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1443 - 1490
Published: Feb. 1, 2025
Abstract: Given the complexity of central nervous system (CNS) and diversity neurological conditions, increasing prevalence disorders poses a significant challenge to modern medicine. These disorders, ranging from neurodegenerative diseases psychiatric not only impact individuals but also place substantial burden on healthcare systems society. A major obstacle in treating these conditions is blood-brain barrier (BBB), which restricts passage therapeutic agents brain. Nanotechnology, particularly use nanoparticles (NPs), offers promising solution this challenge. NPs possess unique properties such as small size, large surface area, modifiable characteristics, enabling them cross BBB deliver drugs directly affected brain regions. This review focuses application gene therapy enzyme replacement (ERT) for disorders. Gene involves altering or manipulating expression can be enhanced by designed carry various genetic materials. Similarly, improve efficacy ERT lysosomal storage (LSDs) facilitating delivery brain, overcoming issues like immunogenicity instability. Taken together, explores potential revolutionizing treatment options highlighting their advantages future directions rapidly evolving field. Keywords: system, nanoparticle, therapy,
Language: Английский
Citations
0