International Journal of Polymeric Materials,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 24
Published: Dec. 20, 2024
Nasal
delivery
of
therapeutics
has
garnered
noteworthy
attention
for
the
treatment
neurological
diseases
due
to
its
noninvasive
nature
and
ability
administer
large
molecules
like
peptides
proteins
small
molecules.
Numerous
benefits
are
associated
with
nasal
mucosa,
such
as
facilitate
quick
absorption,
avoidance
first-pass
metabolism,
simplicity
administration.
However,
efficient
transportation
over
mucosa
remains
challenging
many
physiological
constraints.
This
review
article
explores
techniques
enhance
peptides,
proteins,
across
a
particular
emphasis
on
careful
selection
utilization
materials
mechanisms.
Peptides,
can
be
carried
more
efficiently
using
variety
means,
including
modifying
drug
properties,
co-delivery
systems,
employing
physical
chemical
techniques,
implementing
targeted
strategies.
The
highlights
existing
obstacles
constraints,
possible
uses,
future
pathways
in
domain
delivery.
A
thorough
analysis
methods
used
transporting
through
is
discussed.
Frontiers in Aging Neuroscience,
Journal Year:
2023,
Volume and Issue:
15
Published: June 15, 2023
The
glymphatic
system
is
a
brain-wide
perivascular
pathway
driven
by
aquaporin-4
on
the
endfeet
of
astrocytes,
which
can
deliver
nutrients
and
active
substances
to
brain
parenchyma
through
periarterial
cerebrospinal
fluid
(CSF)
influx
remove
metabolic
wastes
perivenous
clearance
routes.
This
paper
summarizes
composition,
overall
flow,
solute
transport,
related
diseases,
affecting
factors,
preclinical
research
methods
system.
In
doing
so,
we
aim
provide
direction
reference
for
more
relevant
researchers
in
future.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(15)
Published: Feb. 11, 2024
Abstract
Current
management
of
anesthesia‐associated
complications
falls
short
in
terms
both
efficacy
and
safety.
Nanomaterials
with
versatile
properties
unique
nano‐bio
interactions
hold
substantial
promise
as
therapeutics
for
addressing
these
complications.
This
review
conducts
a
thorough
examination
the
existing
nanotherapeutics
highlights
strategies
developing
prospective
nanomedicines
to
mitigate
anesthetics‐related
toxicity.
Initially,
general,
regional,
local
anesthesia
along
commonly
used
anesthetics
related
prevalent
side
effects
are
introduced.
Furthermore,
employing
nanotechnology
prevent
alleviate
is
systematically
demonstrated
from
three
aspects,
that
is,
1)
safe
nano‐formulization
anesthetics;
2)
nano‐antidotes
sequester
overdosed
alter
their
pharmacokinetics;
3)
pharmacodynamic
activities
treat
Finally,
prospects
challenges
facing
clinical
translation
anesthesia‐related
discussed.
work
provides
comprehensive
roadmap
effective
toxicity,
which
can
potentially
revolutionize
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(23), P. 3004 - 3004
Published: Nov. 23, 2023
The
lack
of
effective
treatments
for
neurodegenerative
diseases
(NDs)
is
an
important
current
concern.
Lipid
nanoparticles
can
deliver
innovative
combinations
active
molecules
to
target
the
various
mechanisms
neurodegeneration.
A
significant
challenge
in
delivering
drugs
brain
ND
treatment
associated
with
blood–brain
barrier,
which
limits
effectiveness
conventional
drug
administration.
Current
strategies
utilizing
lipid
and
cell-penetrating
peptides,
characterized
by
uptake
mechanisms,
have
potential
extend
residence
time
bioavailability
encapsulated
drugs.
Additionally,
bioactive
neurotropic
or
neuroprotective
properties
be
delivered
potentially
mediate
targeting
pathways,
e.g.,
neurotrophin
deficiency,
impaired
metabolism,
mitochondrial
dysfunction,
endoplasmic
reticulum
stress,
accumulation
misfolded
proteins
peptide
fragments,
toxic
protein
aggregates,
oxidative
stress
damage,
neuroinflammation.
This
review
discusses
recent
advancements
CPPs
view
integration
these
two
approaches
into
nanomedicine
development
dual-targeted
nanoparticulate
systems
delivery
disorders.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(2), P. 678 - 678
Published: Feb. 17, 2023
Orally
administered
antipsychotic
drugs
are
the
first-line
treatment
for
psychotic
disorders,
such
as
schizophrenia
and
bipolar
disorder.
Nevertheless,
adverse
drug
reactions
jeopardize
clinical
outcomes,
resulting
in
patient
non-compliance.
The
design
formulation
strategies
enhancing
brain
delivery
has
been
a
major
challenge,
mainly
due
to
restrictive
properties
of
blood-brain
barrier.
However,
recent
pharmacokinetic
pharmacodynamic
vivo
assays
confirmed
advantage
intranasal
route
when
compared
oral
intravenous
administration,
it
allows
direct
nose-to-brain
transport
via
neuronal
pathways,
reducing
systemic
side
effects
maximizing
therapeutic
outcomes.
In
addition,
incorporation
into
nanosystems
polymeric
nanoparticles,
mixed
micelles,
solid
lipid
nanostructured
carriers,
nanoemulsions,
nanoemulgels,
nanosuspensions,
niosomes
spanlastics,
proven
be
quite
promising.
developed
nanosystems,
having
small
homogeneous
particle
size
(ideal
delivery),
high
encapsulation
efficiency
good
stability,
resulted
improved
bioavailability
therapeutic-like
animal
models.
Hence,
although
is
essential
continue
research
this
field,
schizophrenia,
disorder
other
related
disorders
promising,
opening
path
future
therapies
with
higher
efficacy.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
173, P. 116339 - 116339
Published: Feb. 29, 2024
Microneedles
(MNs)
prepared
from
polymeric
materials
are
painless
and
minimally
invasive,
safe
efficient,
but
they
hindered
by
low
mechanical
strength
single
diverse
drug
release
pattern.
Due
to
the
distinctive
dimensions
of
poly(lactic-co-glycolic
acid)
(PLGA)
nanoparticles
(NPs),
integration
nano-technology
with
microneedles
can
effectively
improve
penetration
delivery
efficiency
through
stratum
corneum.
We
herein
designed
a
simple
paroxetine
(PAX)-loaded
PLGA
nanoparticles-integrated
dissolving
system
(PAX-NPs-DMNs),
aiming
bioavailability
PAX
synergistic
permeation-enhancing
effect
(DMNs)
NPs.
PAX-NPs-DMNs
had
complete
tips
molding
rate
(Neff)
(94.06
±
2.16)
%,
15×15
quadrangular-conical
microneedle
array
an
overall
fracture
force
301.10
N,
which
were
improved
nearly
0.50
times
compared
blank
(HA-DMNs)
(PAX-DMNs).
could
extend
duration
1
h
24
cumulative
permeability
per
unit
area
(Qn)
was
47.66
7.37
higher
than
PAX-DMNs
groups.
be
rapidly
dissolved
within
10
min
without
hindering
skin
healing
or
causing
adverse
reactions.
This
study
confirmed
that
DMNs,
easily
penetrate
provide
sustained
effects,
thus
offering
more
convenient
effective
method
for
central
nervous
diseases.
Molecular Neurobiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 1, 2024
Abstract
Blood–brain
barrier
(BBB)
is
a
distinguishing
checkpoint
that
segregates
peripheral
organs
from
neural
compartment.
It
protects
the
central
nervous
system
harmful
ambush
of
antigens
and
pathogens.
Owing
to
such
explicit
selectivity,
BBB
hinders
passage
various
neuroprotective
drug
molecules
escalates
into
poor
attainability
agents
towards
brain.
However,
few
can
surpass
gain
access
in
brain
parenchyma
by
exploiting
surface
transporters
receptors.
For
successful
development
brain-targeted
therapy,
understanding
receptors
crucial.
This
review
focuses
on
transporter
receptor–based
mechanistic
pathway
be
manoeuvred
for
better
comprehension
reciprocity
nanotechnological
vehicle
delivery.
Nanotechnology
has
emerged
as
one
expedient
noninvasive
approaches
targeting
via
manipulating
hurdle
BBB.
Various
nanovehicles
are
being
reported
delivery
nanoparticles,
nanocrystals,
nanoemulsion,
nanolipid
carriers,
liposomes
other
nanovesicles.
Nanotechnology-aided
strategic
approach
circumvent
without
altering
inherent
nature
