Neurotherapeutics, Journal Year: 2023, Volume and Issue: 20(4), P. 911 - 913
Published: July 1, 2023
Language: Английский
Alcohol research, Journal Year: 2024, Volume and Issue: 44(1)
Published: Jan. 1, 2024
PURPOSE:By 2040, 21.6% of Americans will be over age 65, and the population those older than 85 is estimated to reach 14.4 million.Although not causative, a risk factor for dementia: every 5 years beyond doubles; approximately one-third are diagnosed with dementia.As current alcohol consumption among adults significantly higher compared previous generations, pressing question whether drinking increases Alzheimer's disease or other forms dementia.SEARCH METHODS: Databases explored included PubMed, Web Science, ScienceDirect.To accomplish this narrative review on effects dementia risk, literature covered clinical diagnoses, epidemiology, neuropsychology, postmortem pathology, neuroimaging biomarkers, translational studies.Searches conducted between January 12 August 1, 2023, following terms combinations: "aging," "alcoholism," "alcohol use disorder (AUD)," "brain," "CNS," "dementia," "Wernicke," "Korsakoff," "Alzheimer," "vascular," "frontotemporal," "Lewy body," "clinical," "diagnosis," "epidemiology," "pathology," "autopsy," "postmortem," "histology," "cognitive," "motor," "neuropsychological," "magnetic resonance," "imaging," "PET," "ligand," "degeneration," "atrophy," "translational," "rodent," "rat," "mouse," "model," "amyloid," "neurofibrillary tangles," "α-synuclein," "presenilin."When relevant, "species" (i.e., "humans" "other animals") was selected as an additional filter.Review articles were avoided when possible.SEARCH RESULTS: The two "alcoholism" "aging" retrieved about 1,350 papers; adding phrases-for example, "postmortem" resonance"-limited number fewer 100 papers.Using traditional term, "dementia" resulted in 876 citations, but using currently accepted term (AUD)" produced only 87 papers.Similarly, whereas "Alzheimer's" yielded 318 results, returned 40 citations.As pertinent pathology papers published 1950s recent animal models created early 2000s, referenced span 1957 2024.In total, more 5,000 considered; 400 herein referenced.DISCUSSION AND CONCLUSIONS: Chronic misuse accelerates brain aging contributes cognitive impairments, including mnemonic domain.The consensus studies from multiple disciplines, however, that can increase dementia, necessarily disease.Key issues consider include reversibility damage abstinence chronic degenerative progressive course disease, characteristic presence protein inclusions brains people which absent AUD.
Language: Английский
Citations
8
Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 23, 2024
Abstract US clinical practice guidelines for the diagnostic evaluation of cognitive impairment due to Alzheimer's disease (AD) or AD and related dementias (ADRD) are decades old aimed at specialists. This evidence‐based guideline was developed empower all—including primary care—clinicians implement a structured approach evaluating patient with symptoms that may represent AD/ADRD. Through modified‐Delphi guideline‐development process (7374 publications were reviewed; 133 met inclusion criteria) an expert workgroup recommendations as steps in patient‐centered process. summary focuses on recommendations, appropriate any setting, forming core elements high‐quality, evidence‐supported characterizing, diagnosing, disclosing patient's functional status, cognitive–behavioral syndrome, likely underlying brain so optimal care plans maximize patient/care partner dyad quality life can be developed; companion article summarizes specialist recommendations. If clinicians use this health‐care systems provide adequate resources, outcomes should improve most patients settings. Highlights
Language: Английский
Citations
8
One Health, Journal Year: 2025, Volume and Issue: unknown, P. 100980 - 100980
Published: Jan. 1, 2025
Rabies is a lethal zoonotic illness that claims over 59,000 lives annually. However, this fatality can be avoided by postexposure prophylaxis (PEP). This study aimed to identify and characterize different personas of individuals regarding their PEP-seeking behavior develop tailored communication strategies encourage PEP adoption among these distinct groups effectively. We categorized our subjects, residing in two districts Chonburi province, Thailand, into three groups: (i) with history dog bites who underwent PEP; (ii) bitten dogs did not receive (iii) had never been bitten. Subsequently, we employed an empathy map, visual method, customer journey map better understand the participants' experiences perceptions. A total 38 were interviewed. participants personas: positive, neutral, negative trends. Individuals classified within positive trend strongly advocate for seeking rabies vaccines event bite. Meanwhile, have neutral inclination are more likely contemplate getting vaccinated following bite, particularly if injury substantial. Those demonstrate notable lack attention or concern toward preventing rabies. potential severity issue characterizes attitude. Notably, nearly half (44.74 %; 17/38) involved indicated utilizing interpersonal communication, followed digital platforms (42.11 16/38) traditional channels (10.52 5/38). Tailoring modalities suit each specific group crucial effective outreach.
Language: Английский
Citations
0
Exploration of Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Aim: Amnestic mild cognitive impairment (aMCI) is a transitional stage toward Alzheimer’s disease (AD). For late-onset AD (95% of cases), aging the main risk factor. Systematizing transcriptome hippocampal neurons under native conditions this essential, as information scarce and hippocampus highly vulnerable cerebral region. Methods: Public microarray data corresponding to homogenates human Healthy-Younger, Healthy-Elder, Elder-with-MCI individuals were re-analyzed herein. Through an optimized computational pipeline, those genes having splice forms that belong neuronal type identified. The differential arising from each group then characterized by contrasting ontologies (functions, cellular components, pathways). Additionally, re-arranged factorially determine first- second-order sex interactions. Results: Around 76% relevant changes actually occurred during healthy-aging process, being further balanced or not MCI. “Cognition”, “behavior”, “glutamatergic synaptic transmission”, “lipid rafts”, “catecholamines” decreased across three groups analyzed, whereas “associative/visual learning”, “gliogenesis”, “neuro-inflammation”, “corticosteroids”, “p75NTR”, “ER-stress” “autophagy” peaked in Elders. On contrary, “Learning/memory”, “GAP junctions”, “GABAergic “GNDF” showed minimum “transcriptional regulators” (MeCP2, NPAS4, DREAM), “BNDF/NGFR”, “Ca2+ transport”, “CRHR1” “CXCL12” minimal From Elder MCI, “MAPKs”, “MEF2C”, “RGS7”, “CCKBR1”, “ErbB4”, “ERK5”, “Ca2+-Na+-K+ channels” (RYR2, SCNA1/A8, KCNQ2/Q3, KCNN3, KCNIP2) appeared downregulated. “Long-term depression” (LTD) increased sharply Most findings detected contrasted against 250 reports. Conclusions: multiple alterations basic mechanisms—mainly CA3 dendrites mossy fibers could be compatible with hyper-excitability, diminished transmission, theta/gamma/SWR rhythms. Many functionalities conditioned sex-interactions. Particularly, women “pure” sex-effects interactions “cross-over” effects. Due its consequences on higher-order functions, all these predictions should confirmed experimentally.
Language: Английский
Citations
0
Aging Brain, Journal Year: 2025, Volume and Issue: 7, P. 100137 - 100137
Published: Jan. 1, 2025
Language: Английский
Citations
0
Physiologia, Journal Year: 2024, Volume and Issue: 4(1), P. 115 - 138
Published: March 7, 2024
The aging of the global population is a significant and complex phenomenon with far-reaching implications for healthcare systems society. By 2030, it projected that number individuals over age 65 will increase by nearly 1 billion, largely due to advancements in improvements quality life. Aging multifaceted process encompasses wide array changes, spanning from cellular level intricate physiological human body. At central nervous system level, represents major risk factor conditions such as depression cognitive impairment, which are likely linked neuroinflammatory processes can potentially lead more severe dementias, including Alzheimer’s disease (AD). higher prevalence AD women compared men has led speculation onset menopause associated phenomena, particularly decline estrogen levels, may play role development disease. Furthermore, research shown physical exercise confers both mental health benefits older adults, experiencing greatest advantages. Understanding nature its ensure adults receive support care essential maintaining their
Language: Английский
Citations
3
Frontiers in Bioscience-Landmark, Journal Year: 2023, Volume and Issue: 28(12), P. 355 - 355
Published: Dec. 28, 2023
Alzheimer's disease is widely regarded as poorly treated due to poor conceptualization. For 40 years, pathophysiology has focused on two culprits, amyloid-β induced plaques and hyperphosphorylated tau associated tangles, with no significant treatment advance. This confounded by data showing be an endogenous antimicrobial that increased in a wide array of diverse medical conditions heightened inflammation. article reviews the wider bodies pertaining pathophysiology, highlighting role suppressed astrocyte mitochondrial function melatonergic pathway core hub driving neuronal loss dementia. It proposed over aging becomes dysregulated, at least partly mediated systemic processes involving 10-fold decrease pineal melatonin leading attenuated capacity night-time dampen residual daytime Suppressed also attenuates melatonin's inhibition glucocorticoid receptor nuclear translocation, thereby changing not only stress/hypothalamus-pituitary-adrenal (HPA) axis consequences but cortisol awakening response, which 'primes body for coming day'. Gut microbiome-derived butyrate inhibits well inducing pathway. prevents autocrine paracrine effects limiting levels effects. production induction lactate, decreasing metabolism The lactate melatonin, coupled suppression decreases mitophagy, major histocompatibility complex (MHC)-1. MHC-1 initiates chemoattraction CD8+ t cells, destruction being driven 'autoimmune'/'immune-mediated' processes. may therefore conceptualized initiated act astrocytes hub, leaving neurons deplete appropriate metabolic substrates co-ordinated antioxidants. culminates 'immune-mediated' cell death. Future research treatment/prevention implications are indicated.
Language: Английский
Citations
8
Journal of Health Service Psychology, Journal Year: 2024, Volume and Issue: 50(1), P. 37 - 46
Published: Feb. 1, 2024
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11720 - 11720
Published: Oct. 31, 2024
Alzheimer's disease (AD) presents a public health challenge due to its progressive neurodegeneration, cognitive decline, and memory loss. The amyloid cascade hypothesis, which postulates that the accumulation of amyloid-beta (Aβ) peptides initiates leading AD, has dominated research therapeutic strategies. failure recent Aβ-targeted therapies yield conclusive benefits necessitates further exploration AD pathology. This review proposes Mitochondrial-Neurovascular-Metabolic (MNM) integrates mitochondrial dysfunction, impaired neurovascular regulation, systemic metabolic disturbances as interrelated contributors pathogenesis. Mitochondrial hallmark leads oxidative stress bioenergetic failure. Concurrently, breakdown blood-brain barrier (BBB) cerebral blood flow, characterize dysregulation, accelerate neurodegeneration. Metabolic such glucose hypometabolism insulin resistance impair neuronal function survival. hypothesis highlights interconnectedness these pathways suggests strategies targeting health, integrity, regulation may offer more effective interventions. MNM addresses multifaceted aspects providing comprehensive framework for understanding progression developing novel approaches. approach paves way innovative could significantly improve outcomes millions affected worldwide.
Language: Английский
Citations
2
Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)
Published: Dec. 3, 2024
Abstract Promising therapeutic strategies are being explored to replace or regenerate the neuronal populations that lost in patients with neurodegenerative disorders. Several research groups have attempted direct reprogramming of astrocytes into neurons by manipulating expression polypyrimidine tract-binding protein 1 (PTBP1) and claimed putative converted be functional, which led improved disease outcomes animal models several However, a few other studies reported data contradict these claims, raising doubt about whether PTBP1 suppression truly reprograms potential this approach. This review discusses recent advances regenerative therapeutics including stem cell transplantations for central nervous system disorders, particular focus on Parkinson’s Alzheimer’s diseases. We also provide perspective controversy considering astrocyte heterogeneity may key understanding discrepancy published studies, certain subpopulations glial cells more readily neurons.
Language: Английский
Citations
1