Current Opinion in Biotechnology, Journal Year: 2023, Volume and Issue: 85, P. 103045 - 103045
Published: Dec. 14, 2023
Language: Английский
Smart Medicine, Journal Year: 2024, Volume and Issue: 3(1)
Published: Jan. 30, 2024
Cancer remains a major global health threat necessitating the multipronged approaches for its prevention and management. Traditional in form of chemotherapy, surgery, radiotherapy are often encountered with poor patient outcomes evidenced by high mortality morbidity, compelling need precision medicine cancer patients to enable personalized targeted treatment. There has been an emergence smart multimodal theranostic nanoformulation triple combination therapy last few years, which dramatically enhances overall safety vivo potential clinical applications minimal toxicity. However, it is imperative gain insight into limitations this system terms translation, cost-effectiveness, accessibility, multidisciplinary collaboration. This review paper aims highlight compare impact recent nanoformulations therapeutics single nanocarrier effective management provide new dimension diagnostic treatment simultaneously.
Language: Английский
Citations
16
Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)
Published: May 9, 2024
Abstract The escalating global challenge of antimicrobial resistance demands innovative approaches. This review delves into the current status and future prospects bioengineered metallic nanoparticles derived from natural sources as potent agents. unique attributes abundance resources have sparked a burgeoning field research in combating microbial infections. A systematic literature was conducted, encompassing wide range studies investigating synthesis, characterization, mechanisms nanoparticles. Databases such PubMed, Scopus, Web Science, ScienceDirect, Springer, Taylor & Francis online OpenAthen were extensively searched to compile comprehensive overview topic. synthesis methods, including green sustainable approaches, examined, diverse biological used nanoparticle fabrication. amalgamation products has yielded promising Their multifaceted mechanisms, membrane disruption, oxidative stress induction, enzyme inhibition, render them effective against various pathogens, drug-resistant strains. Moreover, potential for targeted drug delivery systems using these opened new avenues personalized medicine. Bioengineered represent dynamic frontier battle underscores their remarkable efficacy action. Future are bright, with opportunities scalability cost-effectiveness through methods. However, addressing toxicity, regulatory hurdles, environmental considerations remains crucial. In conclusion, this highlights evolving landscape nanoparticles, offering valuable insights revolutionize therapy future. Graphical
Language: Английский
Citations
16
Aspects of Molecular Medicine, Journal Year: 2025, Volume and Issue: 5, P. 100062 - 100062
Published: Jan. 5, 2025
Citations
5
Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 24 - 24
Published: Jan. 14, 2025
Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation avoid adverse side effects. Recent advancements in biodegradable stimuli-responsive nanomaterials have opened new avenues targeted drug delivery systems capable of addressing these challenges. This review provides a comprehensive analysis state-of-the-art nanocarriers such as polymeric nanoparticles, liposomes, hydrogels engineered autoimmune therapies. These are designed degrade safely the body while releasing agents response specific stimuli, including pH, temperature, redox conditions, enzymatic activity. By achieving localized controlled release anti-inflammatory immunosuppressive agents, minimize toxicity enhance efficacy. We discuss underlying mechanisms nanomaterials, recent applications treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, design considerations essential clinical translation. Additionally, we address current challenges, biocompatibility, scalability, regulatory hurdles, well future directions integrating advanced nanotechnology with personalized medicine treatment. highlights transformative potential presenting them promising strategy advance precision improve patient outcomes disease management.
Language: Английский
Citations
2
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 17, 2025
Since their inception in the early 1960s, development and use of nanoscale materials have progressed tremendously, roles diverse fields ranging from human health to energy electronics are undeniable. The application nanotechnology inventions has revolutionized many aspects everyday life including various medical applications specifically drug delivery systems, maximizing therapeutic efficacy contained drugs by means bioavailability enhancement or minimization adverse effects. In this review, we utilize CAS Content Collection, a vast repository scientific information extracted journal patent publications, analyze trends nanoscience research relevant an effort provide comprehensive detailed picture field. We examine publication landscape area insights into current knowledge advances developments. review major classes nanosized routes, targeted diseases. outline most discussed concepts assess advantages nanocarriers. objective is broad overview evolving regarding challenges, evaluate growth opportunities. merit stems extensive, wide-ranging coverage up-to-date information, allowing unmatched breadth analysis in-depth insights.
Language: Английский
Citations
2
Nanomaterials, Journal Year: 2022, Volume and Issue: 12(15), P. 2672 - 2672
Published: Aug. 4, 2022
Cancer therapies have advanced tremendously throughout the last decade, yet multiple factors still hinder success of different cancer therapeutics. The traditional therapeutic approach has been proven insufficient and lacking in suppression tumor growth. simultaneous delivery small-molecule chemotherapeutic drugs genes improves effectiveness each treatment, thus optimizing efficacy improving synergistic effects. Nanomedicines integrating inorganic, lipid, polymeric-based nanoparticles designed to regulate spatiotemporal release encapsulated drugs. Multidrug-loaded nanocarriers are a potential strategy fight incorporation co-delivery systems as feasible treatment method projected benefits limited undesirable Moreover, development for maximum impact necessitates better knowledge appropriate agent ratio well inherent heterogeneity cells. Co-delivery can simplify clinical processes increase patient quality life, even though such more difficult prepare than single drug systems. This review highlights progress attained design nano carrier-based discusses limitations, challenges, future perspectives fabrication
Language: Английский
Citations
54
Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(2), P. 247 - 247
Published: Jan. 21, 2022
Nanomedicine plays an essential role in developing new therapies through novel drug delivery systems, diagnostic and imaging vaccine development, antibacterial tools, high-throughput screening. One of the most promising systems are nanoparticles, which can be designed with various compositions, sizes, shapes, surface modifications. These nanosystems have improved therapeutic profiles, increased bioavailability, reduced toxicity product they carry. However, clinical translation nanomedicines requires a thorough understanding their properties to avoid problems questioned aspect nanosystems: safety. The particular physicochemical nano-drugs lead need for additional safety, quality, efficacy testing. Consequently, challenges arise during characterization, production process, vitro vivo stages development these biopharmaceuticals. lack specific regulatory framework nanoformulations has caused significant gaps requirements needed successful approval, especially tests that demonstrate safety efficacy. Researchers face many difficulties establishing evidence extrapolate results from one level another, example, demonstration phase phase. Additional guidance is required cover particularities this type product, as some do not allow accurate assessment NPs sufficient success. This work aims identify current issues implementation nanoparticle assays describe major researchers faced when exposing formulation. We further reflect on standards approval biopharmaceuticals demanded by agencies. Our will provide helpful information improve success compiling described literature support encapsulation system. propose step-by-step approach different nanoformulations, design stage, exemplifying measures taken agencies respond challenges.
Language: Английский
Citations
40
Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 74, P. 103526 - 103526
Published: June 18, 2022
Language: Английский
Citations
39
Heliyon, Journal Year: 2023, Volume and Issue: 9(11), P. e21621 - e21621
Published: Oct. 27, 2023
Among many types of wearable sensors, MOFs-based sensors have recently been explored in both commercialization and research. There has much effort various aspects the development MOF-based including but not limited to miniaturization, size control, safety, improvements conformal flexible features, analytical performance long-term storage these devices. Recent progress design deployment are covered this paper, as remaining obstacles prospects. This work also highlights enormous potential for synergistic effects MOFs used combination with other nanomaterials healthcare applications raise attention toward economic aspect market diffusion sensors.
Language: Английский
Citations
32
ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(4), P. 1339 - 1367
Published: April 3, 2023
Graphitic carbon nitride (g-CN) based nanostructures are distinctive materials with unique compositional, structural, optical, and electronic properties exceptional band structure, moderate surface area, thermal chemical stability. Because of these properties, g-CN nanomaterials have shown promising applications higher performance in the biological avenue. This review covers state-of-the-art synthetic strategies used for preparation materials, basic a panorama different optimization leading to improved physicochemical responsible application. The following sections include recent progress use nanobiomaterials biosensors, bioimaging, photodynamic therapy, drug delivery, chemotherapy, antimicrobial segment. Furthermore, we summarized role evaluation biosafety biocompatibility material. Finally, unresolved issues, plausible challenges, current status, future perspectives development design been expected promote clinical path medical sector human well-being.
Language: Английский
Citations
28