Characterization of behavior of the inclusion complex between Sulfobutylether-β-cyclodextrin loaded alginate/chitosan nanoparticles and indomethacin as a potential approach for drug delivery

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 407, P. 125222 - 125222

Published: June 7, 2024

Language: Английский

---

β-Cyclodextrin-based polyelectrolyte complexes for drug delivery

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216581 - 216581

Published: March 11, 2025

Language: Английский

---

Hesperidin: a flavanone with multifaceted applications in the food, animal feed, and environmental fields

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 21, 2024

Abstract Hesperidin, a glycosylated flavanone abundant in nature, is an antioxidant widely researched the pharmaceutical industry for its anti-inflammatory, anticancer, antiviral, anti-aging, cardioprotective and neuroprotective effects. Despite extensive literature highlighting these therapeutic activities, there remains significant gap understanding hesperidin role across other fields. This review aims at demonstrating applications beyond applications, particularly food, feed, environmental For this purpose, brief description of biosynthesis pathway citrus plants provided as well main chemical derivatives. In food industry, derivatives are commercialized dietetic supplements have been studied additives active ingredients edible packaging. Within feed meat and/or eggs from animals supplemented with show higher oxidative stability prolonged shelf life. Moreover, environment research, induces plant tolerance against abiotic factors shows biopesticide activity. Graphical abstract

Language: Английский

---

Supramolecular approach to the design of nanocarriers for antidiabetic drugs: targeted patient-friendly therapy

Russian Chemical Reviews, Journal Year: 2024, Volume and Issue: 93(11), P. RCR5150 - RCR5150

Published: Oct. 30, 2024

Diabetes and its complications derived are among serious global health concerns that critically deteriorate the quality of life patients and, in some cases, result lethal outcome. Herein, general information on pathogenesis, factors aggravating course disease drugs used for treatment two types diabetes briefly discussed. The aim review is to introduce supramolecular strategies currently being developed mellitus present a very effective alternative chemical synthesis, allowing fabrication nanocontainers with switchable characteristics meet criteria green chemistry. Particular attention paid organic (amphiphilic polymeric) formulations, including those natural origin, due their biocompatibility, low toxicity, bioavailability. advantages limitations different nanosystems discussed, emphasis adaptivity noninvasive administration routes.<br>The bibliography includes 378 references.

Language: Английский

---

Nerolidol loaded beta cyclodextrin nanoparticles: a promising strategy for inducing apoptosis in breast cancer cells (MCF-7)

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: May 6, 2025

This study investigates the synthesis, characterization and anticancer efficacy of nerolidol-loaded beta cyclodextrin polymeric nanoparticles (NER-βCD-NPs) against MCF-7 breast cancer cells. Nerolidol, a sesquiterpene with anti-inflammatory, antioxidant, antimicrobial properties, faces challenges poor solubility bioavailability, limiting its therapeutic potential. Breast cancer, leading cause cancer-related deaths in women, necessitates alternative therapies fewer side effects compared to conventional chemotherapy. NER-βCD-NPs were synthesized characterized using UV-visible spectroscopy, fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), dynamic light scattering (DLS), zeta potential analysis differential calorimetry (DSC). Drug encapsulation efficiency vitro release analyzed HPLC, while molecular docking assessed NER-βCD interactions. Characterization confirmed successful nanoparticle synthesis. spectra FTIR indicated encapsulation-specific changes, SEM revealed surface morphology, DLS, DSC analyses demonstrated increased size stability. The was 84.9%, 86% NER at pH 5.4 over 48 h. Docking studies supported strong binding between βCD (binding energy: -3.55 kcal/mol). Cytotoxicity assays showed significant cell inhibition. Mechanistic reactive oxygen species (ROS) generation, mitochondrial dysfunction, nuclear changes cycle arrest G0-G1 phase. Molecular apoptosis through upregulation Bax, Caspase 6, 9 Cytochrome c, alongside Bcl-2 downregulation. These results highlight as promising strategy for therapy, offering targeted delivery enhanced mitigating nerolidol limitations. Further are warranted validate their clinical applications.

Language: Английский

---

An Updated and Comprehensive Review of the Health Benefits and Pharmacological Activities of Hesperidin

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 772, P. 151974 - 151974

Published: May 11, 2025

Language: Английский

---

The role of macrocycles in supramolecular assembly with polymers

Soft Matter, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Supramolecular self-assembly of polymers with macrocycles has attracted the attention because it enables spontaneous creation nanostructures unique properties.

Language: Английский

---

Network Pharmacology Analysis, Molecular Docking Integrated Experimental Verification Reveal the Mechanism of Gynostemma pentaphyllum in the Treatment of Type II Diabetes by Regulating the IRS1/PI3K/Akt Signaling Pathway

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(6), P. 5561 - 5581

Published: June 1, 2024

Gynostemma pentaphyllum (Thunb.) Makino (GP), a plant with homology of medicine and food, as traditional Chinese medicine, possesses promising biological activities in the prevention treatment type 2 diabetes mellitus (T2DM). However, material basis mechanism action GP T2DM have not been fully elucidated. This study aimed to clarify active components, potential targets signaling pathways treating T2DM. The chemical ingredients were collected by combining UPLC-HRMS analysis literature research. Network pharmacology revealed that had 32 components 326 results showed affected mediating insulin resistance pathway, PI3K/Akt pathway FoxO1 which close relationship Molecular docking STAT3, PIK3CA, AKT1, EGFR, VEGFA INSR high affinity compounds GP. In vitro, extracts obviously increased glucose uptake consumption IR-HepG2 cells. levels PI3K, p-AKT, p-GSK3β p-FoxO1 decreased expression p-IRS1, p-GS, PEPCK G6Pase, indicated could promote glycogen synthesis inhibit gluconeogenesis regulating IRS1/PI3K/Akt pathway. demonstrated improve promoting inhibiting through might be alternative therapy for

Language: Английский

---

Hesperetin‐loaded chitosan nanoparticles ameliorate hyperglycemia by regulating key enzymes of carbohydrate metabolism in a diabetic rat model

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(8)

Published: Aug. 1, 2024

The study aimed to investigate the potential of hesperetin-loaded chitosan nanoparticles (HSPCNPs) in alleviating hyperglycemia by modulating key enzymes diabetic rats. Chitosan loaded with hesperetin were prepared using ionic gelation method and characterized Electron microscope (SEM), zeta potential, particle size analysis, Fourier-transform infrared (FT-IR), Energy dispersive spectroscopy (EDS) Encapsulation efficiency Loading efficiency. To induce diabetes, rats fed a high-fat beef tallow diet for 28 days, then given single dose streptozotocin (STZ) at 35 mg/kg b.w 0.1 M citrate buffer (pH 4.0). Rats treated HSPCNPs doses 10, 20, 40 b.w. analyzed parameters included body weight, food water intake, plasma glucose insulin, liver skeletal muscle glycogen levels, carbohydrate metabolism. SEM imaging revealed dimensions between 124.2 251.6 nm mean 145.0 nm. FT-IR analysis confirmed presence functional groups nanoparticles, was 35.5 mV. HSPCNP significantly (p < 0.05) reduced blood levels glycosylated hemoglobin, improving reducing intake. In rats, metabolism like fructose 1,6-bisphosphatase, phosphoenolpyruvate carboxykinase, 6-phosphatase are evaluated liver, while 6 phosphate dehydrogenase hexokinase activity lower. Additionally, insulin increased, indicating enhanced sensitivity. results show that ameliorate provide robust protection against complications improve metabolic health.

Language: Английский

---

Chitosan/hesperidin nanoparticles formulation: a promising approach against ethanol-induced gastric ulcers via Sirt1/FOXO1/PGC-1α/HO-1 pathway

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 9, 2024

Hesperidin (Hes) protects different organs from damage by acting as a potent antioxidant and anti-inflammatory. This study aims to evaluate the gastroprotective effects of free hesperidin its chitosan nanoparticles (HNPs) against ethanol-induced gastric ulcers in rats, hypothesizing that HNPs will enhance bioavailability therapeutic efficacy due improved solubility targeted delivery. were synthesized via ion gelation characterized using TEM, SEM, zeta potential analyses. Key assessments included acidity, histological analysis, markers inflammation, oxidative stress, apoptosis. significantly decreased reduced inflammatory apoptotic markers, enhanced enzyme activities compared esomeprazole. Furthermore, Sirt-1, PGC-1α, HO-1, FOXO1 gene expression also evaluated. raised downregulated FOXO1, they suppressed NF-κB p65, COX-2, IL-1β, CD86, P53, caspase-3 increased Sirt-1 activity. treatment notably restored activity, stress outcomes more effectively than These results indicate ulcers, potentially offering effective strategy. Further research should explore clinical applications human subjects.

Language: Английский

---