Preparation and Characterization of Tiamulin-Loaded Niosomes for Oral Bioavailability Enhancement in Mycoplasma-Infected Broilers DOI Creative Commons

Shimaa G. Abonashey,

Amr Gamal, Hatem A. F. M. Hassan

et al.

Micro, Journal Year: 2024, Volume and Issue: 4(4), P. 734 - 750

Published: Nov. 27, 2024

Mycoplasma infections pose significant challenges in the poultry industry, necessitating effective therapeutic interventions. Tiamulin, a veterinary antibiotic, has demonstrated efficacy against species. However, emergence of resistant species could dramatically reduce potential, contributing to economic losses. Optimizing tiamulin’s pharmacokinetic profile via nanocarrier incorporation enhance its potential and administration frequency, ultimately reducing strain emergence. Niosomes, type self-assembled non-ionic surfactant-based nanocarrier, have emerged as promising drug delivery system, offering improved stability, sustained release, enhanced bioavailability. In this study, niosomal nanocarriers encapsulating tiamulin were prepared, characterized assessed Mycoplasma-inoculated broilers following oral administration. Differential scanning colorimetry (DSC) confirmed alterations crystalline state components integration into structures formed during formulation procedure. Transmission electron microscopy (TEM) showed spherical nanostructure niosomes. The formulated exhibited zeta average hydrodynamic diameter −10.65 ± 1.37 mV 339.67 30.88 nm, respectively. Assessment parameters gallisepticum-infected revealed ability increase bioavailability systemic exposure, marked by significantly higher area under curve (AUC) (p < 0.01) prolonged elimination half-life (T1/2) 0.05). Enhanced residence time are crucial factors maintaining concentrations at reduced doses frequencies. This approach provides viable strategy decrease risk subtherapeutic levels, thereby mitigating development antibiotic resistance. findings presented herein offer sustainable for efficient use antibiotics medicine.

Language: Английский

Formulation, preparation of niosome loaded zinc oxide nanoparticles and biological activities DOI Creative Commons

Hossein Rezaei,

Alireza Iranbakhsh, Abbas Akhavan Sepahi

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 19, 2024

Abstract In this study, zinc oxide nanoparticles (Zn-NPs) were prepared by the green synthesis method and loaded inside niosomes as a drug release system their physicochemical biological properties determined. Zn-NPs eco-friendly strategy, structure, morphological studied into niosomes. Subsequently, different formulations of containing optimal formulation was used for studies. Scanning electron microscope (SEM) dynamic light scattering (DLS) to investigate morphology size nanoparticles. Fourier transform infrared spectroscopy (FTIR) UV–Vis confirm Zn-NPs. Energy dispersive X-ray spectrometer (EDS) determined elemental analysis solution crystalline structure analysed XRD (X-Ray diffraction). Furthermore, niosomes, structural characteristics, entrapment efficiency (EE%), profile Zn-NPs, stability also assessed. Moreover, its antimicrobial against some microbial pathogens, effect on expression biofilm genes, anticancer activity breast cancer cell lines To study cytocompatibility, exposure normal HEK-293 cells carried out. addition, impact genes involved in apoptosis ( Bcl2 , Casp3 Casp9 Bax ) at mRNA level measured. Our findings revealed that have round shape an average 27.60 nm. Meanwhile, UV–Vis, FTIR, results confirmed Also, EE% optimized niosomal 31.26% 256.6 ± 12 nm, respectively. The showed within 24 h, 26% released from while same period, 99% free released, which indicates slow Antimicrobial effects exhibited had more significant anti-biofilm than alone, increased 2 4 times. Cytotoxic indicated when are increases compared alone has low cytotoxicity cells. Niosomes ZnNPs apoptosis-related gene reduced genes. general, show can increase therefore be suitable carrier targeted delivery

Language: Английский

Citations

13
Facile sonochemically-assisted bioengineering of titanium dioxide nanoparticles and deciphering their potential in treating breast and lung cancers: biological, molecular, and computational-based investigations DOI Creative Commons
Nada K. Sedky, Noha Khalil Mahdy, Nour M. Abdel-Kader

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(12), P. 8583 - 8601

Published: Jan. 1, 2024

Combining sonochemistry with phytochemistry is a modern trend in the biosynthesis of metallic nanoparticles (NPs), which contributes to sustainability chemical processes and minimizes hazardous effects.

Language: Английский

Citations

11
From antigen uptake to immune modulation: the multifaceted potential of peptide nanofibers as vaccine nanocarriers DOI Creative Commons
Hatem A. F. M. Hassan, Mohamed Haider, Sherif Ashraf Fahmy

et al.

Materials Advances, Journal Year: 2024, Volume and Issue: 5(10), P. 4112 - 4130

Published: Jan. 1, 2024

Peptide nanofibers have exhibited a remarkable ability to enhance immune response induction. Herein, we explore the peptide nanofibers' transformative potential, providing comprehensive examination of their application in vaccine development.

Language: Английский

Citations

4
Synergistic Enhancement of Carboplatin Efficacy through pH-Sensitive Nanoparticles Formulated Using Naturally Derived Boswellia Extract for Colorectal Cancer Therapy DOI Creative Commons
Sherif Ashraf Fahmy, Nada K. Sedky, Hatem A. F. M. Hassan

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1282 - 1282

Published: Sept. 30, 2024

Carboplatin (Cp) is a potent chemotherapeutic agent, but its effectiveness constrained by associated side effects. Frankincense, an oleo-gum resin from the

Language: Английский

Citations

4
Manipulated Slow Release of Florfenicol Hydrogels for Effective Treatment of Anti-Intestinal Bacterial Infections DOI Creative Commons
Wanhe Luo, Mengdi Zhang, Yongtao Jiang

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 541 - 555

Published: Jan. 1, 2025

The difficulty of establishing slow release at intestinal infection sites, weak antibacterial effects, as well the limited broad use florfenicol oral formulations are main targets current study. Novel hydrogels derived from sodium alginate were developed using a complexation form for delivery to achieve site and enhance its activity against Escherichia coli. optimal formulation, physicochemical properties, stability, pH-responsive performance, activity, in vitro biosafety have been studied systematically. created had consistent spherical morphology, with an average diameter 531.9±12.6 nm. Energy dispersive spectroscopy Fourier transform infrared indicated that successfully prepared through force. Furthermore, it is shown hold outstanding excellent sustained release, faster swelling pH due pH-responsiveness. no obvious structural destruction simulated gastric juice (pH=1.2) 12 hrs highly stable. However, began be destroyed after 5 minutes fluid (SIF), this decomposition was continuous. With structure hydrogels, encapsulated also slowly released, thus, achieves slow-release effect. Additionally, showed low hemolytic ratio greater compared florfenicol. blended formulation creates promising matrix intended along gastrointestinal tract.

Language: Английский

Citations

0
Self-assembled and intestine-targeting florfenicol nano-micelles effectively inhibit drug-resistant Salmonella typhimurium, eradicate biofilm, and maintain intestinal homeostasis DOI Creative Commons
Runan Zuo,

Linran Fu,

Wei Pang

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101226 - 101226

Published: Feb. 1, 2025

Language: Английский

Citations

0
Solidified reverse micellar solution-based chitosan-coated solid lipid nanoparticles as a new approach to enhance oral delivery of artemether in malaria treatment DOI Creative Commons
Franklin Chimaobi Kenechukwu,

Kingsley Chinazam Ugwu,

Chibuzor Stanley Offorbuike

et al.

BMC Chemistry, Journal Year: 2025, Volume and Issue: 19(1)

Published: March 8, 2025

Solidified reverse micellar technology and surface-modification are promising techniques for improving the biopharmaceutical properties of poorly water-soluble drugs such as artemether, a first-line antimalarial drug. Thus, aim this study was to develop evaluate artemether-loaded chitosan-coated solid lipid nanoparticles (SLNs) based on solidified solution (SRMS) improved oral malaria therapy. Artemether-loaded unloaded SLNs were prepared from optimized SRMS (consisting Phospholipon® 90G Compritol® ATO 888 at 3:7 ratio) with or without chitosan by high-shear melt-homogenization, thereafter characterized physicochemical performance, stability, safety activity using Plasmodium berghei-infected mice. Results showed both smooth irregular particles layer polymer coating in chitosan-modified SLNs, increased drug amorphization well compatibility excipients employed formulations. The formulation stable nanomeric (size 292.90 ± 5.01 nm, polydispersity index 0.191 0.09, zeta-potential + 32.50 1.58 mV) good encapsulation efficiency (82.03%), demonstrated minimal toxicity Caco-2 cells, exhibited controlled release compared fast artemether suspension gave significantly (p < 0.05) greater than suspension. SRMS-based can be pursued novel alternative treatment.

Language: Английский

Citations

0
Combination of Antimicrobial Drugs with Nanocarrier Drug Delivery System for Veterinary Therapeutics DOI
Kanchanlata Tungare,

Prashant Gurav,

Ameyota De

et al.

Livestock diseases and management, Journal Year: 2025, Volume and Issue: unknown, P. 201 - 220

Published: Jan. 1, 2025

Language: Английский

Citations

0
PREPARATION AND ASSESSMENT OF NAIL LACQUER INCORPORATING CICLOPIROX OLAMINE-LOADED NIOSOMES DOI Open Access
Ayushi Chauhan, Mansi Butola, Vikash Jakhmola

et al.

Asian Journal of Pharmaceutical and Clinical Research, Journal Year: 2025, Volume and Issue: unknown, P. 169 - 174

Published: April 7, 2025

Objective: The emergence of transungual drug delivery systems represents a significant advancement in treating nail-related conditions, particularly fungal infections like onychomycosis. current study aims to formulate ciclopirox olamine (CPO)-loaded niosomal nail lacquer for the treatment Methods: CPO niosomes were synthesized using thin-film hydration method, incorporating different proportions cholesterol, Span 60, and Tween 40. Niosomes assessed their content, encapsulation efficiency, particle size, zeta potential. Results: Among various formulations niosomes, formulation F5 showed adequate loading 94.51%, polydispersity index 0.171, potential −5.10 mV. Following that, optimized (F5) suspension was used develop formulation. maximum vitro release, achieving rate 92.22%. ex vivo conducted Franz diffusion cell apparatus, resulting release approximately 90.67%. zone inhibition obtained found more than pure solution. Conclusion: oral administration antifungal agents, such as allylamines azoles, is associated with numerous adverse effects from requirement high dosages. These issues can be addressed by formulating medications lacquer, significantly lower dosages treatment, which consequently leads reduced side

Language: Английский

Citations

0
Florfenicol core–shell composite nanogels as oral administration for efficient treatment of bacterial enteritis DOI
Wanhe Luo, Jinhuan Wang, Mengdi Zhang

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124499 - 124499

Published: July 20, 2024

Language: Английский

Citations

1