Combating Breast Cancer-associated Metastasis using Paclitaxel and Tranilast-loaded Human Serum Albumin Nanoparticles DOI
Naitik Jain,

Syed Shahrukh,

Paras Famta

et al.

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: May 22, 2025

The objective of the current study is to combat breast cancer-associated metastasis using paclitaxel (PTX) and tranilast (TRA)-loaded human serum albumin (HAS) Nanoparticles. This combinatorial therapy microtubule stabilizing agent PTX, along with TGFβ inhibitor TRA.TRA may offer an improved therapeutic effect in cancer by inhibiting cell proliferation metastasis. Inspired remarkable anticancer properties both drugs, they were encapsulated into HSA nanoparticles enhance tumor site-specific drug accumulation ensure sustained release over a prolonged period. fabricated desolvation method optimized Box-Behnken design (BBD) three-level, two-factor approach. Further, these characterized TEM, FTIR, XRD, particle size. In vitro experiments conducted MDA-MB-231 line, employing viability, cellular uptake, nuclear staining, scratch assay, cycle analysis. kinetics reveal PTX TRA from nanoparticles. Wound healing assay depicted anti-migratory activity PTX-TRA-NPs (30nM-75μM). Furthermore, novel combination treatment caused G2/M phase arrest, as indicated delivery hydrophobic drugs (PTX TRA) cells, offering outcomes. strategy permits further preclinical investigation for synergistic management.

Language: Английский

QbD Manoeuvred Niclosamide Laden Polylactic-co-Glycolic Acid Nanoparticles-Impregnated Gelatin Nanofibers for the Management of Oral Carcinoma DOI
Saurabh Shah,

Paras Famta,

Rahul Kumar

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 5, 2025

Language: Английский

Citations

8
Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities DOI Open Access
Md. Ataur Rahman, Maroua Jalouli,

Mahesh Kumar Yadab

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 701 - 701

Published: Feb. 19, 2025

Glioblastoma multiforme (GBM) is a highly malignant brain tumor that has bleak outlook despite existing treatments such as surgery, radiation, and chemotherapy. The utilization of nanoparticles for drug delivery presents promising method by which to improve the effectiveness treatment while reducing harmful effects on entire body. This review examines application in GBM, focusing different types nanoparticles, including lipid-based, polymeric, metallic, those under development. Every variety analyzed its distinct characteristics therapeutic capacity. Lipid-based liposomes solid lipid enhance transport medicines are not soluble water have shown considerable potential preclinical investigations. Polymeric benefits terms controlled release targeted distribution, whereas metallic both therapy imaging. In current we would like emphasize ways medicine delivery, specifically enhancing penetration blood-brain barrier (BBB), targeting tumors, enabling release. Additionally, also discuss clinical discoveries, highlighting achievements obstacles process converting these technologies into effective GBM. study offers thorough examination present status prospects

Language: Английский

Citations

5
Navigating the Brain: Harnessing Endogenous Cellular Hitchhiking for Targeting Neoplastic and Neuroinflammatory Diseases DOI Creative Commons

Suraj Wagh,

Paras Famta,

Saurabh Shah

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 20(2), P. 101040 - 101040

Published: Feb. 27, 2025

Cellular hitchhiking is an emerging therapeutic strategy that uses endogenous cell migration mechanism to deliver therapeutics specific sites in the body. Owing low permeability and presence of blood-brain barrier (BBB), targeted delivery limited, leading inadequate localization brain. NCs fail extravasate significantly into tumor microenvironment (TME), demonstrating poor accumulation penetration. The novel cellular concept has been utilized promote systemic half-life targeting. Neoplastic neuroinflammatory diseases brain, including glioblastoma neuroinflammation, face critical hurdles for efficiently delivering entities owing BBB. can surmount these by utilizing various populations, such as stem cells, monocytes/macrophages, neutrophils, platelets, potential functional carriers cargo through These carrier cells have innate capability traverse BBB, transit brain parenchyma, specifically reach disease inflammatory neoplastic lesions chemotactic navigation, i.e., movement attributed chemical stimuli. Chemotherapeutic drugs delivered achieve tumor-specific targeting discussed. This article explores types TME with in-depth mechanisms characterization techniques decipher backpack dissociation dynamics (nanoparticle payload detachment characteristics from hitchhiked cells) challenges toward prospective clinical translation.

Language: Английский

Citations

4
Nanoparticle-enhanced delivery of resveratrol for targeted therapy of glioblastoma: Modulating the Akt/GSK-3β/NF-kB pathway in C6 glioma cells DOI
Gurpreet Singh,

Paras Famta,

Saurabh Shah

et al.

Brain Research, Journal Year: 2024, Volume and Issue: unknown, P. 149411 - 149411

Published: Dec. 1, 2024

Language: Английский

Citations

6
Metal-Organic Frameworks as Therapeutic Chameleons: Revolutionizing the Cancer Therapy Employing Novel Nanoarchitectonics DOI Creative Commons

Sajja Bhanu Prasad,

Akshay Shinde,

Dadi A. Srinivasrao

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101054 - 101054

Published: April 1, 2025

Language: Английский

Citations

0
Next-Generation Transformable Nanomedicines: Revolutionizing Cancer Drug Delivery and Theranostics DOI

Swapnil Shinde,

Saurabh Shah,

Paras Famta

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

Nanomedicine has significantly advanced the treatment of various cancer phenotypes, addressing numerous challenges associated with conventional therapies. Researchers have extensively investigated physicochemical properties nanocarriers, such as charge, morphology, and surface chemistry, to optimize drug delivery systems. In context transformable nanomedicine, these are particularly critical for overcoming existing limitations, including suboptimal blood circulation times, sequestration by reticuloendothelial system mononuclear phagocyte system, inefficient targeting tumor microenvironment (TME). Alterations in nanocarrier geometry, hydrophilicity shown potential mitigating barriers, offering improved therapeutic outcomes enhanced biomedical applications. This review explores controlled modulation anticancer therapy, an in-depth exploration strategies activated both internal external stimuli. We analyze implications tunable characteristics on pharmacokinetics, biodistribution, targeted TME. Additionally, we address current clinical translation nanocarriers propose overcome obstacles enhance feasibility nanomedicine-based

Language: Английский

Citations

0
Establishment and Evaluation of Paclitaxel and Simvastatin-Laden Nanofibers for Post-surgical Tumor Recurrence in Breast Cancer DOI

Paras Famta,

Saurabh Shah,

Ganesh Vambhurkar

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(3)

Published: May 21, 2025

Language: Английский

Citations

0
Immunotoxicity Study of Cucurbit[n]urils (n = 6, 7, 8) and Modeling of Interaction with Some Monocyte Receptors by a Molecular Docking Method DOI Creative Commons
Saule B. Zhautikova,

Nursipat N. Abdykhanova,

Dmitriy A. Fedorishin

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(10), P. 2249 - 2249

Published: May 21, 2025

In this study, cucurbit[n]urils (n = 6, 7, 8) were carefully evaluated for their cytotoxicity and immunotoxicity to human peripheral blood monocytes. The was studied by evaluating the survival of monocytes, while level assessed analyzing inflammatory mediators secreted them using an enzyme-linked immunosorbent assay. It found that in used concentration (10−5 M) do not cause a negative effect on cell viability, which is maintained at above 50%. At same time, pro-inflammatory activation monocytic macrophages. absence stimulation cytokine expression demonstrates promising biocompatibility compounds, crucial successful clinical use. obtained results molecular modeling show possibility formation CB[6], CB[7], CB[8] associates with various Toll-like receptors, also confirms good prospects development new ways medical application cucurbit[n]urils.

Language: Английский

Citations

0
Combating Breast Cancer-associated Metastasis using Paclitaxel and Tranilast-loaded Human Serum Albumin Nanoparticles DOI
Naitik Jain,

Syed Shahrukh,

Paras Famta

et al.

Drug Development and Industrial Pharmacy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: May 22, 2025

The objective of the current study is to combat breast cancer-associated metastasis using paclitaxel (PTX) and tranilast (TRA)-loaded human serum albumin (HAS) Nanoparticles. This combinatorial therapy microtubule stabilizing agent PTX, along with TGFβ inhibitor TRA.TRA may offer an improved therapeutic effect in cancer by inhibiting cell proliferation metastasis. Inspired remarkable anticancer properties both drugs, they were encapsulated into HSA nanoparticles enhance tumor site-specific drug accumulation ensure sustained release over a prolonged period. fabricated desolvation method optimized Box-Behnken design (BBD) three-level, two-factor approach. Further, these characterized TEM, FTIR, XRD, particle size. In vitro experiments conducted MDA-MB-231 line, employing viability, cellular uptake, nuclear staining, scratch assay, cycle analysis. kinetics reveal PTX TRA from nanoparticles. Wound healing assay depicted anti-migratory activity PTX-TRA-NPs (30nM-75μM). Furthermore, novel combination treatment caused G2/M phase arrest, as indicated delivery hydrophobic drugs (PTX TRA) cells, offering outcomes. strategy permits further preclinical investigation for synergistic management.

Language: Английский

Citations

0