Chitosan: An overview of biological activities, derivatives, properties, and current advancements in biomedical applications

Carbohydrate Research, Journal Year: 2024, Volume and Issue: 542, P. 109199 - 109199

Published: June 27, 2024

Language: Английский

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Synthesis of a novel green biopolymer-based composites beads for removal of methylene blue from aquatic medium: isotherm, thermodynamic and kinetic investigation

Polymer Bulletin, Journal Year: 2024, Volume and Issue: 81(7), P. 6603 - 6640

Published: Feb. 15, 2024

Abstract The increase in the world population and decrease clean water resources people's interest purification technologies. Many industries, such as textile industry, leather cosmetics food color their products with substances dyes pigments. In this study, a cheap, useful, innovative, environmentally friendly, sustainable adsorbent was developed for removal of Methylene Blue (MB), one that is harmful to environment. fruit tree cultivation, addition product, very high amounts by-products/waste (branches, bark, leaves, seeds, shells, etc.) are produced. direction, walnut olive wastes were immobilized chitosan, made magnetic (m-WCH m-OCH), adsorption MB on adsorbents examined batch system. Characterization synthesized biocomposite performed by FT-IR, SEM, EDX XRD analyzes. It has been thoroughly described how pH solution dye compares PZC surface. values m-WCH m-OCH 5.2 5.5 respectively. biocomposites depends environment (3–8), amount (2–10 gL −1 ), contact time (5–360 min), temperature (25–55 °C) initial concentration (10–250 ppm) function. obtained data evaluated kinetic isotherm models. Using equilibrium from studies using adsorbents, suitability Langmuir, Freundlich, Stachard, Dubinin–Radushkevich Temkin models examined. empirical showed agreement Langmuir model. maximum capacity estimated be 85.47 mg g 53.48 , result higher selectivity m-OCH. Among applied, pseudo-second-order model identified highest regression coefficients. light these results, it determined there new promising natural origin, capacity, lower cost, alternatives commercially used aqueous media. Graphical abstract

Language: Английский

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CdIn2Se4@chitosan heterojunction nanocomposite with ultrahigh photocatalytic activity under sunlight driven photodegradation of organic pollutants

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131465 - 131465

Published: April 9, 2024

Language: Английский

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Reimagining Chitosan‐Based Antimicrobial Biomaterials to Mitigate Antibiotic Resistance and Alleviate Antibiotic Overuse: A Review

Macromolecular Materials and Engineering, Journal Year: 2024, Volume and Issue: 309(9)

Published: Feb. 24, 2024

Abstract This paper reports recent advancements in chitosan‐based antimicrobial biomaterials that aim to address the issue of resistance (AMR). Today, AMR is one most significant public health challenges world facing. To combat overuse antibiotics, a range materials, including advanced nanosized polymers, have been explored as potential agents. In this direction, chitosan scores highly because its unique combination properties such biodegradability, biocompatibility, bioactivity, non‐toxic, and, importantly, intrinsic antibacterial and antifungal activity. Herein, an overview derivatives alternatives conventional therapeutics reported. review starts with understanding mechanism, which critical for developing suitable materials treating infectious diseases. Then, inherent characteristics, modes action, factors impact effectiveness are discussed. The authors further summarize various clinical trial results Finally, applications summary, offers new insights into design sustainable applications.

Language: Английский

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Update on Chitin and Chitosan from Insects: Sources, Production, Characterization, and Biomedical Applications

Biomimetics, Journal Year: 2024, Volume and Issue: 9(5), P. 297 - 297

Published: May 15, 2024

Insects, renowned for their abundant and renewable biomass, stand at the forefront of biomimicry-inspired research offer promising alternatives chitin chitosan production considering mounting environmental concerns inherent limitations conventional sources. This comprehensive review provides a meticulous exploration current state insect-derived chitosan, focusing on sources, methods, characterization, physical chemical properties, emerging biomedical applications. Abundant insect sources from Lepidoptera, Coleoptera, Orthoptera, Hymenoptera, Diptera, Hemiptera, Dictyoptera, Odonata, Ephemeroptera orders, were comprehensively summarized. A variety characterization techniques, including spectroscopy, chromatography, microscopy, used to reveal properties like molecular weight, degree deacetylation, crystallinity, laying solid foundation wide application, especially biomimetic design process. The examination extends into realm applications, highlighting unique advantages in wound healing, tissue engineering, drug delivery, antimicrobial therapies. Their intrinsic biocompatibility position them as candidates innovative solutions diverse medical interventions.

Language: Английский

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Folate-engineered chitosan nanoparticles: next-generation anticancer nanocarriers

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 31, 2024

Chitosan nanoparticles (NPs) are well-recognized as promising vehicles for delivering anticancer drugs due to their distinctive characteristics. They have the potential enclose hydrophobic molecules, thereby enhancing solubilities, permeabilities, and bioavailabilities; without use of surfactant, i.e., through surfactant-free solubilization. This allows higher drug concentrations at tumor sites, prevents excessive toxicity imparted by surfactants, could circumvent resistance. Moreover, biomedical engineers formulation scientists can also fabricate chitosan NPs slowly release agents. keeps site longer, makes therapy more effective, lowers frequency dosing. Notably, some types cancer cells (fallopian tube, epithelial tumors ovary, primary peritoneum; lung, kidney, ependymal brain, uterus, breast, colon, malignant pleural mesothelioma) overexpression folate receptors (FRs) on outer surface, which lets folate-drug conjugate–incorporated target kill them effectively. Strikingly, there is evidence suggesting that excessively produced FR&αgr (isoforms FR) stays consistent throughout treatment in ovarian endometrial cancer, indicating resistance conventional treatment; this regard, folate-anchored overcome it improve therapeutic outcomes. Interestingly, overly expressed FRs present only certain types, a biomarker predicting effectiveness FR-targeted therapy. On other hand, folate-modified enhance oral absorption medicines, especially drugs, pave way effective long-term low-dose metronomic scheduling poorly soluble permeable drugs. In review, we talked briefly about techniques used create, characterize, tailor chitosan-based NPs; delved deeper into applications folate-engineered treating various types. Schematic illustration ligand-drug incorporated its advantage cancer. Figure created with BioRender.Com.

Language: Английский

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Chitosan-based dental barrier membrane for periodontal guided tissue regeneration and guided bone regeneration: A review

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139504 - 139504

Published: Jan. 5, 2025

Language: Английский

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Use of Insect-Derived Chitosan for the Removal of Methylene Blue Dye from Wastewater: Process Optimization Using a Central Composite Design

Materials, Journal Year: 2023, Volume and Issue: 16(14), P. 5049 - 5049

Published: July 17, 2023

Insects are a readily available source of chitosan due to their high reproductive rates, ease breeding, and resistance changes in ecosystem. This study aimed extract from several widespread insects: Blaps lethifera (CS-BL), Pimelia fernandezlopezi (CS-PF), Musca domestica (CS-MD). The was also extended using the obtained chitosans removing methylene blue dye (MB) wastewater. chitosan, initial concentration MB dye, reaction time were chosen as working parameters. experiments designed central composite design (CCD) based on removal efficiency response variable. experimental work statistical calculation CCD showed that ranged 35.9% 88.7% for CS-BL, 18.8% 47.1% CS-PF, 10.3% 29.0% CS-MD at an 12.79 mg/L. highest CS-BL 120 min. indicates extraction insects (Blaps lethifera) its application is promising, environmentally friendly, economical, biodegradable, cost-effective process. Furthermore, technique can be used optimize process variables other organic pollutants chitosan.

Language: Английский

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Recent Advances in the Preparation, Antibacterial Mechanisms, and Applications of Chitosan

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(11), P. 318 - 318

Published: Oct. 27, 2024

Chitosan, a cationic polysaccharide derived from the deacetylation of chitin, is widely distributed in nature. Its antibacterial activity, biocompatibility, biodegradability, and non-toxicity have given it extensive uses medicine, food, cosmetics. However, significant impact variations physicochemical properties chitosan extracted different sources on its application efficacy, as well considerable differences antimicrobial mechanisms under varying conditions, limit full realization biological functions. Therefore, this paper provides comprehensive review structural characteristics chitosan, preparation methods sources, mechanisms, factors influencing efficacy. Furthermore, we highlight latest applications derivatives across various fields. We found that use microbial extraction shows promise new method for producing high-quality chitosan. By analyzing chitosan-based materials (such nanoparticles, films, sponges, hydrogels) prepared using biomedicine, agriculture, cosmetics, expect these findings to provide theoretical support broader utilization

Language: Английский

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Chitosan coated biomass waste-based magnetic hydrogel beads for the removal of methylene blue

International Journal of Phytoremediation, Journal Year: 2024, Volume and Issue: 26(9), P. 1500 - 1517

Published: March 15, 2024

Due to developing technology and increasing population, human needs have increased, textile activities gained momentum. Many synthetic dyestuffs are used meet the in this field. In study, a cheap, useful, innovative, environmentally friendly sustainable adsorbent was developed for removal of Methylene Blue(MB), which is one dyes that harmful environment. cultivation fruit trees, addition product, very high amounts by-products/waste (garbage, branches, bark, leaves, etc.) produced. direction, fig tree wastes were immobilized with chitosan, made magnetic, MB adsorption on examined batch system. Glutaraldehyde as crosslinker. Characterization synthesized glutaraldehyde cross-linked chitosan-coated magnetic vegetable waste composite beads (g-CMBW) carried out by SEM, EDX, FTIR XRD. effects temperature (25–55 °C), pH (3.0–8.0), initial concentration (10–250mg/L), contact time (5–360min) amount (2–10 g/L) g-CMBW examined. The optimum conditions obtained determined 6.0, 25 °C, 6 g/L, 120 min. maximum capacity using calculated 103.1 mg/g according Langmuir isotherm model. studies showed decreased temperature, showing system exothermic. light these results, it there new promising adsorbents natural origin, higher capacity, lower cost, alternatives commercially from aqueous media.

Language: Английский

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