Hyaluronic Acid-Based pH-Sensitive Nanogel: Synthesis, Characterization, and Assessment for Acyclovir Delivery In Vitro and In Vivo DOI
Tarek A. A. Moussa, Heba Ali Abd El‐Rahman,

Riham R. Mohamed

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 26(1), P. 341 - 362

Published: Dec. 25, 2024

Acyclovir (ACV) is a potentially effective antiviral medication; however, it has serious drawback, which its poor solubility, bioavailability, and short half-life. The goal of this study to improve drawbacks through the synthesis nanogels. In study, cross-linked hyaluronic acid-grafted poly(acrylamide-co-itaconic acid) nanogel synthesized successfully free radical polymerization used as safe pH-responsive carrier for ACV. nanogels showed pH response in vitro vivo. prepared C5 (1:1 ratio acrylamide: itaconic), had highest grafting efficiency, maximum swelling, drug loading, release 7.4, higher than 1.2. Also, C5, large surface area, good stability, matrices shrank acidic medium protected drug, while basic medium, expanded released ACV sustained manner improved bioavailability half-life

Language: Английский

White clover components as an effective biosorbent for the elimination of toxic malachite green from wastewater DOI

Salma Gul,

Sana Afsar,

Tawaf Ali Shah

et al.

Biomass Conversion and Biorefinery, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Language: Английский

Citations

1
In-situ constructed tactic of palladium nanoparticles supported on hierarchical porous wood-derived cellulose framework towards efficient catalytic reduction on 4-nitrophenol DOI
Qianqian Yu, Xiaohan Sun, Meiying Wu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141675 - 141675

Published: March 6, 2025

Language: Английский

Citations

0
A practical and environmentally sustainable approach to dye removal: Synthesis and characterization of a highly efficient crosslinked chitosan-Schiff base adsorbent for Eriochrome Black T removal DOI
Magda F. Mohamed,

Amira A. Hamed,

Alaa A. Kashmiry

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142048 - 142048

Published: March 1, 2025

Language: Английский

Citations

0
A Comprehensive Review of Methylene Blue Dye Adsorption on Activated Carbon from Edible Fruit Seeds: A Case Study on Kinetics and Adsorption Models DOI Creative Commons

Safaa Talib Al-Asadi,

Zainab Haider Mussa,

Fouad Fadhil Al-Qaim

et al.

Carbon Trends, Journal Year: 2025, Volume and Issue: unknown, P. 100507 - 100507

Published: April 1, 2025

Language: Английский

Citations

0
Hyaluronic Acid-Based pH-Sensitive Nanogel: Synthesis, Characterization, and Assessment for Acyclovir Delivery In Vitro and In Vivo DOI
Tarek A. A. Moussa, Heba Ali Abd El‐Rahman,

Riham R. Mohamed

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: 26(1), P. 341 - 362

Published: Dec. 25, 2024

Acyclovir (ACV) is a potentially effective antiviral medication; however, it has serious drawback, which its poor solubility, bioavailability, and short half-life. The goal of this study to improve drawbacks through the synthesis nanogels. In study, cross-linked hyaluronic acid-grafted poly(acrylamide-co-itaconic acid) nanogel synthesized successfully free radical polymerization used as safe pH-responsive carrier for ACV. nanogels showed pH response in vitro vivo. prepared C5 (1:1 ratio acrylamide: itaconic), had highest grafting efficiency, maximum swelling, drug loading, release 7.4, higher than 1.2. Also, C5, large surface area, good stability, matrices shrank acidic medium protected drug, while basic medium, expanded released ACV sustained manner improved bioavailability half-life

Language: Английский

Citations

3