The role of galanin in the progression and prognosis of colorectal cancer: the unfinished story DOI Creative Commons
Zbigniew Kmieć, Jacek Kieżun, Bartłomiej E. Kraziński

et al.

European Journal of Histochemistry, Journal Year: 2024, Volume and Issue: 68(1)

Published: March 6, 2024

The paper presents a summary of immunohistochemical (IHC) and biochemical investigations on the presence galanin (Gal), one neuropeptides abundant in enteric nervous systems, three types its receptors (GalR1-3) colorectal cancer (CRC) tissue non-involved colon wall their associations with clinical-pathological data CRC patients. We were first to morphologically demonstrate endogenous Gal sections measure content homogenates tumor dissected compartments unchanged wall. prominent atrophy myenteric plexuses displaying immunoreactivity (Gal-Ir) located close invasion was found be accompanied by higher tumor-adjacent muscularis externa than tumor-distant tissue. In further studies for time, we demonstrated IHC technique GalR1-3 tumors mucosa that GalR3-Ir correlated longer overall survival Furthermore, discovered lower GalR1 expression submucosal near better prognosis patients CRC. These findings suggest could considered as novel therapeutic target conclusion, our morphological provided documenting involvement progression showed usefulness

Language: Английский

Unraveling the peripheral nervous System's role in tumor: A Double-edged Sword DOI
Yanhao Wang, Yang Xuan,

Cuicui Liu

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: 611, P. 217451 - 217451

Published: Jan. 8, 2025

Language: Английский

Citations

2
MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer DOI Creative Commons
Hao Wang,

Kexin He,

Ruixue Huo

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract Perineural invasion (PNI), characterized by tumor cells surrounding and invading nerves, is associated with poor prognosis in colorectal cancer (CRC). Understanding the mechanisms of PNI crucial for developing targeted therapies to impede progression. In this study, clinical information transcriptome data are obtained from TCGA database. Stable MAGEA6 knockdown CRC cell lines established investigate impact on malignancy. Immunohistochemical staining used assess significance MAGEA6. Rectal orthotopic sciatic nerve models employed verify role PNI. Schwann (SCs) infiltration recruitment assessed using ssGSEA co‐culture experiments. The results reveal that a key regulator PNI, its expression correlating prognosis. reduces migration, invasion, ability. Moreover, recruit SCs, CXCL1 promoting SCs migration. Mechanistically, inhibits YY1 ubiquitination, stabilizing enhancing SC via YY1‐mediated transcription. These findings suggest enhances invasiveness YY1, which upregulates secretion promotes recruitment. This interaction underscores critical highlights potential therapeutic target CRC.

Language: Английский

Citations

1
Evaluation of a new scoring system for assessing nerve invasion in resected pancreatic cancer: a single-center retrospective analysis DOI
Rong Hua, Hong-Fei Yao,

Zi-Yu Song

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 603, P. 217213 - 217213

Published: Sept. 6, 2024

Language: Английский

Citations

6
Tumor Neurobiology in the Pathogenesis and Therapy of Head and Neck Cancer DOI Creative Commons
Siyuan Liang, Jochen Heß

Cells, Journal Year: 2024, Volume and Issue: 13(3), P. 256 - 256

Published: Jan. 30, 2024

The neurobiology of tumors has attracted considerable interest from clinicians and scientists become a multidisciplinary area research. Neural components not only interact with tumor cells but also influence other elements within the TME, such as immune vascular components, forming polygonal relationship to synergistically facilitate growth progression. This review comprehensively summarizes current state knowledge on nerve-tumor crosstalk in head neck cancer discusses potential underlying mechanisms. Several mechanisms facilitating are covered, perineural invasion, axonogenesis, neurogenesis, neural reprogramming, transdifferentiation, reciprocal interactions between nervous systems TME discussed this review. Further understanding may provide new nerve-targeted treatment options help improve clinical outcomes for patients.

Language: Английский

Citations

5
Schwann cells and enteric glial cells: Emerging stars in colorectal cancer DOI

Kexin He,

Hao Wang,

Ruixue Huo

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(5), P. 189160 - 189160

Published: July 24, 2024

Language: Английский

Citations

4
Nervous system in colorectal cancer DOI
Chunjie Xu, Chunhui Jiang, Yuan Tian

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217431 - 217431

Published: Dec. 1, 2024

Language: Английский

Citations

4
Assessment of cfDNA release dynamics during colorectal cancer surgery DOI Open Access
Mayron Barbosa Lopes, Maria Elvira Ribeiro Cordeiro, Fellype Carvalho Barreto

et al.

Oncotarget, Journal Year: 2025, Volume and Issue: 16(1), P. 29 - 38

Published: Jan. 21, 2025

Approximately two-thirds of patients with colorectal cancer (CRC) undergo resection curative intent; however, 30% to 50% these experience recurrence. The concentration cell-free DNA (cfDNA) before and after surgery may be related the prognosis CRC, but there is limited information regarding cfDNA levels at time surgery. Here, we analyzed surgical release using plasma samples from 30 three key points during surgery: preoperative (immediately surgery), intraoperative (during postoperative (at end surgery). Automated electrophoresis was used analyze concentrations fragment sizes, which were then correlated clinical variables. Our findings indicate a significant increase in (2.8- 2.2-fold higher respectively, p < 0.01). Characteristic fragments (<400 bp) predominated all stages; genomic material (>400 also observed. We found that increases over 60 years old (2.9-fold intraoperatively than preoperatively 2.3 folds postoperatively preoperatively, 0.01); comorbidities (3.0-fold 2.3-fold postoperatively, CEA >5 ng/mL (3.1-fold 1.3-fold Interestingly, significantly adverse characteristics. Patients bearing locally advanced tumors or metastasis had 3.1-fold 2.4-fold 0.01. high score tumor buds (2.6 higher, 0.02), perineural invasion (3.4-fold 0.02) lymphovascular 0.05). Furthermore, observed rise correlation duration surgery, highlighting its potential as marker quality. Taken together, our results suggest addition physiological age, unfavorable traits, intense manipulation tumor's extent, result greater tissue damage elevated release.

Language: Английский

Citations

0
Radiomics for prediction of perineural invasion in colorectal cancer: a systematic review and meta-analysis DOI
Ning Tang,

S Pan,

Q Zhang

et al.

Abdominal Radiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

Citations

0
Stage‐specific characterization of “early‐onset colorectal cancer”: Localized and synchronous metastatic disease DOI Creative Commons
Erman Akkuş, Beliz Bahar Karaoğlan, Mehmet Kayaalp

et al.

International Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Abstract Early‐onset colorectal cancer (EOCRC) is an alarming entity worldwide. Yet, stage‐specific characteristics and prognosis in localized synchronous metastatic EOCRC are not well‐defined. Two cohorts of CRC patients (localized metastatic) were evaluated, defining as the diagnosis <50 years old. Five hundred sixty‐eight included ( n = 432 localized, 14.4% [ 62] 136 metastatic, 20.6% 28] EOCRC). 93.5% 96.5% symptomatic at diagnosis. Among patients, female gender (58.1% vs. 40%, p .008), perineural invasion (41.9% 24.9%, .005), folinic acid, 5‐fluorouracil, oxaliplatin chemotherapy (45.2% 25.2%, .003), perioperative cycles (9.21 [± 3.10] 7.98 2.92], .006) higher compared with ≥50‐year. Median recurrence‐free survival (RFS) overall reached either group .234 .831). Only RAS mutant status was associated RFS (Hazard ratio: 7.09 [95% confidence interval (CI): 1.87–26.76], < .001) EOCRC. urgent surgery (32.1% 11.1%, .014) local treatments (39.3% 20.4%, .037) more frequent progression‐free ≥50 8.07 months (95% CI: 5.03–12.97) 10.03 CI, 8.40–13.10) .450) 18.57 13.33–43.03) 19.83 16.07–27.30) .833), respectively. Synchronous frequently underwent 8%, .008) had mutation (43.5% 16.7%, .032) than This study suggests that may have different average onset, without differences. Implementation into daily practice necessary for decision‐making processes these young patients.

Language: Английский

Citations

0
Central nervous system and immune cells interactions in cancer: unveiling new therapeutic avenues DOI Creative Commons
Ji Wen, Yue Li,

Wanli Deng

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Cancer remains a leading cause of mortality worldwide. Despite significant advancements in cancer research, our understanding its complex developmental pathways inadequate. Recent research has clarified the intricate relationship between central nervous system (CNS) and cancer, particularly how CNS influences tumor growth metastasis via regulating immune cell activity. The interactions cells regulate microenvironment various signaling pathways, cytokines, neuropeptides, neurotransmitters, while also incorporating processes that alter immunological landscape. Furthermore, therapeutic strategies targeting neuro-immune interactions, such as checkpoint inhibitors, alongside advanced technologies like brain-computer interfaces nanodelivery systems, exhibit promise improving treatment efficacy. This bidirectional regulatory network significantly affects development, metastasis, patient status, therapy responses. Therefore, mechanisms CNS-immune is crucial for developing innovative strategies. work consolidates evaluates their potential strategies, provides insights future approaches.

Language: Английский

Citations

0