European Journal of Histochemistry,
Journal Year:
2024,
Volume and Issue:
68(1)
Published: March 6, 2024
The
paper
presents
a
summary
of
immunohistochemical
(IHC)
and
biochemical
investigations
on
the
presence
galanin
(Gal),
one
neuropeptides
abundant
in
enteric
nervous
systems,
three
types
its
receptors
(GalR1-3)
colorectal
cancer
(CRC)
tissue
non-involved
colon
wall
their
associations
with
clinical-pathological
data
CRC
patients.
We
were
first
to
morphologically
demonstrate
endogenous
Gal
sections
measure
content
homogenates
tumor
dissected
compartments
unchanged
wall.
prominent
atrophy
myenteric
plexuses
displaying
immunoreactivity
(Gal-Ir)
located
close
invasion
was
found
be
accompanied
by
higher
tumor-adjacent
muscularis
externa
than
tumor-distant
tissue.
In
further
studies
for
time,
we
demonstrated
IHC
technique
GalR1-3
tumors
mucosa
that
GalR3-Ir
correlated
longer
overall
survival
Furthermore,
discovered
lower
GalR1
expression
submucosal
near
better
prognosis
patients
CRC.
These
findings
suggest
could
considered
as
novel
therapeutic
target
conclusion,
our
morphological
provided
documenting
involvement
progression
showed
usefulness
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: July 25, 2024
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
an
aggressive
malignant
tumor
with
a
high
metastatic
potential.
Perineural
invasion
(PNI)
occurs
in
the
early
stages
of
PDAC
incidence
rate
and
directly
associated
poor
prognosis.
It
involves
close
interaction
among
cells,
nerves
microenvironment.
In
this
review,
we
detailed
discuss
PNI-related
pain,
six
specific
steps
PNI,
treatment
PNI
emphasize
importance
novel
technologies
for
further
investigation.
Cancer Letters,
Journal Year:
2024,
Volume and Issue:
611, P. 217433 - 217433
Published: Dec. 28, 2024
The
nervous
system
governs
both
ontogeny
and
oncology.
Foundational
discoveries
have
clarified
the
direct
communication
of
neurotransmitters
with
tumors
indirect
interactions
through
neural
effects
on
immune
tumor
microenvironment.
Meantime,
is
susceptible
to
cancer
its
treatment.
Chemotherapy-induced
peripheral
neuropathy
(CIPN)
most
common
side
that
significantly
reduce
efficacy
anti-cancer
treatment
patients'
quality
life
by
leading
dose
reduction
or
early
cessation
chemotherapy.
However,
there
are
no
effective
strategies
reverse
treat
CIPN.
A
better
understanding
mechanisms
expected
enable
development
next
generation
therapies.
Here,
we
summarize
recent
important
studies
clinical
manifestations,
risk
factors,
prediction,
pathogenesis,
prevention,
We
also
provide
perspectives
insights
regarding
rationales
bidirectional
between
system.
European Journal of Histochemistry,
Journal Year:
2024,
Volume and Issue:
68(1)
Published: March 6, 2024
The
paper
presents
a
summary
of
immunohistochemical
(IHC)
and
biochemical
investigations
on
the
presence
galanin
(Gal),
one
neuropeptides
abundant
in
enteric
nervous
systems,
three
types
its
receptors
(GalR1-3)
colorectal
cancer
(CRC)
tissue
non-involved
colon
wall
their
associations
with
clinical-pathological
data
CRC
patients.
We
were
first
to
morphologically
demonstrate
endogenous
Gal
sections
measure
content
homogenates
tumor
dissected
compartments
unchanged
wall.
prominent
atrophy
myenteric
plexuses
displaying
immunoreactivity
(Gal-Ir)
located
close
invasion
was
found
be
accompanied
by
higher
tumor-adjacent
muscularis
externa
than
tumor-distant
tissue.
In
further
studies
for
time,
we
demonstrated
IHC
technique
GalR1-3
tumors
mucosa
that
GalR3-Ir
correlated
longer
overall
survival
Furthermore,
discovered
lower
GalR1
expression
submucosal
near
better
prognosis
patients
CRC.
These
findings
suggest
could
considered
as
novel
therapeutic
target
conclusion,
our
morphological
provided
documenting
involvement
progression
showed
usefulness
