Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 735, P. 150804 - 150804
Published: Oct. 9, 2024
Language: Английский
Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111394 - 111394
Published: Jan. 1, 2025
Language: Английский
Citations
0
Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110324 - 110324
Published: Feb. 1, 2025
Language: Английский
Citations
0
Chemical Communications, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Redox dynamics in Wilson's disease and cuproptosis were elucidated using a reversible ratiometric fluorescent probe, WD-Redox, providing insights into oxidative stress, copper metabolism disorders, therapeutic evaluations of d -penicillamine.
Language: Английский
Citations
0
Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(3), P. 715 - 719
Published: March 13, 2024
Osteoporosis (OP)-associated fractures can result in severe morbidity and disability, reduced quality of life, death. Previous studies have suggested that small noncoding RNAs, for example, regulatory microRNAs (miRNAs), play a key role OP by inhibiting target gene expression. Cuproptosis, recently proposed copper-induced cell death pathway, is linked with OP. Here, we describe the contribution exosomal miRNAs cuproptosis to First, highlight characteristics exosomes roles exosome-related miRNAs. Next, discuss relationship between Subsequently, analyze crosstalk development This review aims investigate new clinical treatment method
Language: Английский
Citations
3
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Journal Year: 2024, Volume and Issue: 32(9), P. 1389 - 1399
Published: Jan. 1, 2024
Resveratrol (RSV), the primary polyphenol found in grapes, has been revealed to have anti-inflammatory properties by reducing capacity of peripheral blood mononuclear cells produce pro-inflammatory cytokines, including IL-1β, IL-6, IL-1ra and TNFα. Considering close association between chronic inflammation cancer development, RSV's immunomodulatory are one way which may inhibit initiation, proliferation, neovascularization, migration. influences generation microtumor environment is key factors progress. In addition immunomodulation, RSV inhibits development expressing anti-oxidant effects, causing cell cycle arrest, stimulating function certain enzymes, activating signaling pathways. The end outcome various forms death, apoptosis, pyroptosis, necroptosis, more, as it observed
Language: Английский
Citations
3
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117100 - 117100
Published: July 15, 2024
Gastric cancer (GC) is the fifth most prevalent type of in whole world. Cuproptosis discovered as a programmed cell death pathway and connected to cells' growth death, well tumorigenesis. The relationship between cuproptosis GC still elusive. Two aspects this study will elaborate immunotherapy biomarkers GC. Notably, herein review intended highlight what has been accomplished regarding for diagnosis, immunotherapy, prognosis aim offer potential directions strategies future research inside
Language: Английский
Citations
3
Metallomics, Journal Year: 2024, Volume and Issue: 16(10)
Published: Oct. 1, 2024
Copper (Cu) is a vital micronutrient necessary for proper development and function of mammalian cells tissues. Cu mediates the redox active enzymes that facilitate metabolic processes signaling pathways. levels are tightly regulated by network Cu-binding transporters, chaperones, small molecule ligands. Extensive research has focused on homeostasis (cuprostasis) pathologies, which result from mutations perturbations. There roles proteins as transcription factors (Cu-TFs) regulators mediate metal through activation or repression genes associated with handling. Emerging evidence suggests some Cu-TFs may be involved in regulation targets related to development-expanding biological proteins. implicated embryonic tissue-specific alongside mediation cellular response oxidative stress hypoxia. also neurological disorders, providing new biomarkers therapeutic diseases such Parkinson's disease, prion Friedreich's ataxia. This review provides critical analysis current understanding role cuproproteins transcriptional regulation.
Language: Английский
Citations
3
Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 273, P. 106986 - 106986
Published: June 2, 2024
Language: Английский
Citations
1
Journal of Orthopaedic Reports, Journal Year: 2024, Volume and Issue: unknown, P. 100472 - 100472
Published: Sept. 1, 2024
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11657 - 11657
Published: Oct. 30, 2024
Copper is crucial for many physiological processes across mammalian cells, including energy metabolism, neurotransmitter synthesis, and antioxidant defense mechanisms. However, excessive copper levels can lead to cellular toxicity "cuproptosis", a form of programmed cell death characterized by the accumulation within mitochondria. Tumor cells are less sensitive this than normal mechanism which remains unclear. We address important issue exploring role heat shock factor 1 (HSF1), transcription that highly expressed several types cancer has in tumor survival, protecting against copper-mediated cytotoxicity. Using pancreatic ductal adenocarcinoma we show triggers proteotoxic stress response (PSR), activating HSF1 overexpressing diminishes intracellular prevents copper-induced amyloid fibrils formation, highlighting HSF1's preserving proteasomal integrity. treatment decreases lipoylation dihydrolipoamide S-acetyltransferase (DLAT), an enzyme necessary cuproptosis, induces DLAT oligomerization, insoluble suppressed HSF1, addition enhancing interaction between DLAT. Our findings uncover how protects damage thus represents novel therapeutic target death.
Language: Английский
Citations
1