Prevention of Mutagenesis, Oxidative Stress and Inflammation in first Generation Male Rats whose Parents are Exposed to Gamma Radiation and Hexavalent Chromium DOI
Yerbolat Iztleuov, Marat Iztleuov,

Altynbek Dushmanov

et al.

Salud Ciencia y Tecnología, Journal Year: 2024, Volume and Issue: 5, P. 1259 - 1259

Published: Dec. 17, 2024

Introduction: Children exposed to radiation chemical agents or born parents faced elevated risks of stochastic pathologies, including genetic disorders, tumours, and leukaemia. These were attributed mutations latent genomic damage caused by such exposures. Methods: This six-month experimental study at NAO ZKMU in Kazakhstan evaluated Burdock Root Oil's protective effects against gamma hexavalent chromium-induced 100 Wistar rats, analyzed using Statistica 10.Results: The findings revealed that the offspring combined chromium irradiation (Cr⁶⁺ + γ) exhibited a 33% increase micronuclei (6.3 ±1.16‰, P ≤ 0.01) compared controls (4.56 ± 1.18‰), indicating significant genotoxicity. Oil reduced levels 5.34 0.792‰ (P≥ 0.05), comparable control levels. Chromosomal aberrations Cr⁶⁺+ γgroup increased 54% (2.77 0.537%, 0.001), while total 19.5% (P 0.005). Markers oxidative stress showed improvement; superoxide dismutase (SOD) activity 16.7%, catalase 22.6%, sulfhydryl groups 23% (P≤ malondialdehyde decreased 16% 0.05). SH/MDA ratio 45% 0.05).Conclusions: effectively mitigated genotoxic, oxidative, inflammatory chromium. It restored immune balance, stress, preserved stability

Language: Английский

Protective effects of herbal compounds against cyclophosphamide-induced organ toxicity: a pathway-centered approach DOI

Prathap Srirangan,

Evan Prince Sabina

Drug and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 43

Published: Jan. 23, 2025

Cyclophosphamide is a key component of numerous chemotherapeutic protocols, demonstrating broad-spectrum efficacy against various malignancies and non-cancerous conditions. This review examines CPM's metabolic pathways, therapeutic applications, its resulting organ-specific toxicities. Despite clinical benefits in treating nephrotic syndrome, encephalomyelitis, breast cancer, ovarian other diseases, CPM associated with significant adverse effects on the kidneys, liver, heart, lungs, intestines. The discussion delves into molecular mechanisms underlying these toxicities, highlighting dysregulation signaling including Nrf2, NF-κB, MAPK/ERK, AKT. In addressing challenges, recent studies have identified herbal drugs phytochemicals capable mitigating CPM-induced toxicity. Notable compounds such as cinnamaldehyde, baicalin, quercetin, curcumin demonstrated protective effects. Integrating formulations therapy proposed to enhance patient safety treatment efficacy. underscores influence apoptosis inflammation which lead alterations biomarkers. Phytochemicals may exert by restoring disrupted pathways normalizing altered compilation presented this serves valuable resource for researchers exploring products potential A gap current literature lack trials evaluating that mitigate toxicity vivo. Rigorous are necessary establish cancer treatment. Such research will clarify role natural remedies complementing conventional therapies, ultimately improving outcomes.

Language: Английский

Citations

1
Exploring the Therapeutic Potential of Esculetin in Mitigating Cyclophosphamide-Induced Hepato-Toxicity DOI

Prathap Srirangan,

Evan Prince Sabina

Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Language: Английский

Citations

1
Whole genome sequencing data of greater burdock (Arctium lappa) naturalized in the United States of America DOI Creative Commons

Danae Kala Rodriguez Bardaji,

Girish Kumar, Stella Tran

et al.

Data in Brief, Journal Year: 2025, Volume and Issue: unknown, P. 111508 - 111508

Published: March 1, 2025

Language: Английский

Citations

0
Fabrication and biological properties of electrospun chitosan/polyethylene oxide nanofibrous scaffolds loaded with the Arctium lappa L. extract DOI

Dehghan Navaei Ardeh,

Mohammad Sadegh Nourbakhsh,

Arash Montazeri

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142544 - 142544

Published: March 1, 2025

Language: Английский

Citations

0
Targeted miRNA Delivery in Epilepsy: Mechanisms, Advances, and Therapeutic Potential DOI

Mukul Shyam,

Oveyaa Bm,

Prathap Srirangan

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 7, 2025

Language: Английский

Citations

0
Diabetic retinopathy: a comprehensive review of pathophysiology and emerging treatments DOI

Mukul Shyam,

Sidharth Sen,

Aleen Veronica

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 9, 2025

Language: Английский

Citations

0
The Role of Dietary Ingredients and Herbs in the Prevention of Non-Communicable Chronic Liver Disease DOI Open Access
Monika Maćków, Tomasz Dziubyna, Tatiana Jamer

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(20), P. 3505 - 3505

Published: Oct. 16, 2024

Background: Liver diseases are among the most commonly diagnosed conditions, with main risk factors being inappropriate lifestyles, including poor diet, excessive alcohol consumption, low physical activity and smoking, electronic cigarettes. Non-communicable chronic liver also often develop as a result of accompanying overweight obesity, well type 2 diabetes. Methods: The literature on for non-communicable diseases, which show high strong influence their occurrence, was analysed. Results: Measures to prevent disease include selection suitable food ingredients that have proven protective effects liver. Such dietary fibre, probiotics, herbs, various types polyphenols fatty acids (omega-3). Conclusions: Because liver-protective effects, nutritionists recommend consuming vegetables, fruits, herbs spices provide valuable anti-inflammatory anti-cancer effects. These components should be provided and, in case supplementation appears important. As preventive measure, diet rich these nutrients is therefore recommended, one prevents other can disease.

Language: Английский

Citations

1
Prevention of Mutagenesis, Oxidative Stress and Inflammation in first Generation Male Rats whose Parents are Exposed to Gamma Radiation and Hexavalent Chromium DOI
Yerbolat Iztleuov, Marat Iztleuov,

Altynbek Dushmanov

et al.

Salud Ciencia y Tecnología, Journal Year: 2024, Volume and Issue: 5, P. 1259 - 1259

Published: Dec. 17, 2024

Introduction: Children exposed to radiation chemical agents or born parents faced elevated risks of stochastic pathologies, including genetic disorders, tumours, and leukaemia. These were attributed mutations latent genomic damage caused by such exposures. Methods: This six-month experimental study at NAO ZKMU in Kazakhstan evaluated Burdock Root Oil's protective effects against gamma hexavalent chromium-induced 100 Wistar rats, analyzed using Statistica 10.Results: The findings revealed that the offspring combined chromium irradiation (Cr⁶⁺ + γ) exhibited a 33% increase micronuclei (6.3 ±1.16‰, P ≤ 0.01) compared controls (4.56 ± 1.18‰), indicating significant genotoxicity. Oil reduced levels 5.34 0.792‰ (P≥ 0.05), comparable control levels. Chromosomal aberrations Cr⁶⁺+ γgroup increased 54% (2.77 0.537%, 0.001), while total 19.5% (P 0.005). Markers oxidative stress showed improvement; superoxide dismutase (SOD) activity 16.7%, catalase 22.6%, sulfhydryl groups 23% (P≤ malondialdehyde decreased 16% 0.05). SH/MDA ratio 45% 0.05).Conclusions: effectively mitigated genotoxic, oxidative, inflammatory chromium. It restored immune balance, stress, preserved stability

Language: Английский

Citations

0