Early Life Nutrition and Mental Health: The Role of DNA Methylation

Nutrients, Journal Year: 2021, Volume and Issue: 13(9), P. 3111 - 3111

Published: Sept. 4, 2021

Does the quality of our diet during early life impact long-term mental health? Accumulating evidence suggests that nutrition interacts with genes and there is a strong association between health throughout life. Environmental influences such as maternal pregnancy or offspring have been shown to cause epigenetic changes critical periods development, chemical modifications DNA histones by methylation for regulation gene expression. One-carbon metabolism, which consists folate methionine cycles, influenced generates S-Adenosylmethinoine (SAM), main methyl donor reactions histone methylation. This review provides current knowledge on how levels one-carbon metabolism associated micronutrients choline, betaine, folate, B vitamins play role in brain function can well-being across lifespan. Micronutrients act donors SAM formation could affect global methylation, altering expression phenotype. Strategies should then be adopted better understand these nutrients work their at different stages development provide individualized dietary recommendations outcomes.

Language: Английский

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Maternal Vitamin D Levels during Pregnancy and Offspring Psychiatric Outcomes: A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 24(1), P. 63 - 63

Published: Dec. 21, 2022

Prenatal exposure to vitamin D may play a significant role in human brain development and function. Previous epidemiological studies investigating the associations between maternal status offspring developmental psychiatric outcomes humans have been inconclusive. We aimed systematically assess results of previously published that examined levels, measured as circulating 25(OH)D levels pregnancy or at birth, neuropsychiatric outcomes. Systematic searches were conducted using MEDLINE, Embase, PsychINFO Web Science for by 10 August 2022. included observational prenatal perinatal English peer-reviewed journals. Of 3729 identified, 66 screened full texts 29 2003 2022 final review. There was small amount evidence association deficiency autism spectrum disorder. When with larger sample sizes stricter definitions considered, positive also found attention-deficit/hyperactivity disorder schizophrenia. Future sizes, longer follow-up periods assessed multiple time points are needed.

Language: Английский

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Infant Formula Supplemented With Milk Fat Globule Membrane, Long-Chain Polyunsaturated Fatty Acids, and Synbiotics Is Associated With Neurocognitive Function and Brain Structure of Healthy Children Aged 6 Years: The COGNIS Study

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: March 9, 2022

Adequate nutrient intake during the first few months of life plays a critical role on brain structure and function development.To analyze long-term effects an experimental infant formula (EF) neurocognitive in healthy children aged 6 years compared to those fed with standard or breastfed.The current study involved 108 participating COGNIS Study. At 0-2 months, infants were randomized receive up 18 (SF) EF enriched milk fat globule membrane (MFGM), long-chain polyunsaturated fatty acids (LC-PUFAs) synbiotics. Furthermore, reference group breastfed (BF) also recruited. Children assessed using tests structural Magnetic Resonance Imaging (MRI) at old.Experimental showed greater volumes left orbital cortex, higher vocabulary scores IQ, better performance attention task than BF children. presented parietal regions SF kids. Additionally, cortical thickness insular, parietal, temporal areas found from groups. Further correlation analyses suggest that different frontal are associated cognitive development terms language (verbal comprehension) executive (working memory). Finally, arachidonic acid (ARA), adrenic (AdA), docosahexaenoic (DHA) levels cheek cell glycerophospholipids, ARA/DHA ratio, protein, acid, mineral seem be changes structures old.Supplemented MFGM components, LC-PUFAs, synbiotics seems old.https://www.clinicaltrials.gov/, identifier: NCT02094547.

Language: Английский

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Existing and Future Strategies to Manipulate the Gut Microbiota With Diet as a Potential Adjuvant Treatment for Psychiatric Disorders

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 95(4), P. 348 - 360

Published: Nov. 1, 2023

Language: Английский

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Invited review: Iodine level in dairy products—A feed-to-fork overview

Journal of Dairy Science, Journal Year: 2023, Volume and Issue: 106(4), P. 2213 - 2229

Published: March 2, 2023

The theme of iodine in the dairy sector is particular interest due to involvement and interconnection several stakeholders along food chain. Iodine plays a fundamental role animal nutrition physiology, cattle it an essential micronutrient during lactation for fetal development calf's growth. Its correct use supplementation crucial guarantee animal's recommended daily requirement avoid excess intake long-term toxicity. Milk public health, being one major sources Mediterranean Western diets. Public authorities scientific community have made great efforts address how what extent different drivers may affect milk concentration. literature concurs that amount administered through feed mineral supplements most important factor affecting its concentration common species. Additionally, farming practices related milking (e.g., iodized teat sanitizers), herd management pasture vs. confinement), other environmental factors seasonality) been identified as variation Overall, aim this review provide multilevel overview on mechanisms contribute products.

Language: Английский

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The effect of soy isoflavones in brain development: the emerging role of multiple signaling pathways and future perspectives

Endocrine Journal, Journal Year: 2024, Volume and Issue: 71(4), P. 317 - 333

Published: Jan. 1, 2024

Soybean is a source of protein, fibers, and phytochemical isoflavones which are considered to have numerous health benefits for children adulthood. On the other hand, widely known as phytoestrogens that exert their action via estrogen signaling pathway. With this regard, also endocrine-disrupting chemicals. Endogenous plays crucial role in brain development through binding receptors (ERs) or G protein-coupled 1 (GPER1) regulates morphogenesis, migration, functional maturation, intracellular metabolism neurons glial cells. Soy can bind ERs, GPER1, and, furthermore, modulate action. Therefore, soy isoflavone consumption may affect during pre-and post-natal periods. This review summarizes current knowledge on mechanisms action, particularly early stages by introducing representative human, animal models, vitro studies, discusses beneficial adverse impact neurobehavior. As conclusion, product periods under proper range dose showed effects neurobehavior development, including improvement anxiety, aggression, hyperactive behavior, cognition, whereas effect taking higher doses cannot be excluded. We present novel research lines further assess administration development.

Language: Английский

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The Prevalence of Anemia among Pregnant Women in China: A Systematic Review and Meta-Analysis

Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1854 - 1854

Published: June 13, 2024

The systematic review and meta-analysis were conducted to ascertain the prevalence of anemia, iron deficiency (ID), anemia (IDA) among Chinese pregnant women. A total 722 articles on maternal during pregnancy published between January 2010 December 2020 compiled, a 57 eligible studies including 1,376,204 women in different subgroups. results showed that ID, IDA China 30.7% (95% CI: 26.6%, 34.7%), 45.6% 37.0%, 54.2%), 17.3% 13.9%, 20.7%), respectively. All increased with progression pregnancy. There sizable regional variations IDA. Generally, lower was observed economically more advanced eastern region country, while ID higher than western region. rural areas urban areas, but areas. In conclusion, differences urban–rural disparities indicate need for context-specific interventions prevent treat anemia. It found dietary factors one major causes iron-containing supplements nutrition counseling could be effective reduce

Language: Английский

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Nutrition and growth in children

Minerva Pediatrica, Journal Year: 2021, Volume and Issue: 72(6)

Published: Jan. 1, 2021

The well-balanced nourishment during "the first 1000 days," the period between conception (day 18) and age of two years, is quite important for main reasons. Firstly, nutritive requirement high due to rapid physiological growth functional development. Then, this characterized by extreme susceptibility external stimuli such as inadequate maternal infant nutritional status which they can interfere with different stages development process leading short long-term consequences health. Linear brain are particularly impaired from not sufficient nutrition. In consideration irreversible damage malnutrition, especially on developing brain, an adequate nutrition days life paramount. aim review was overview latest scientific evidences relationship growth, focusing requirements days, impact linear growth.

Language: Английский

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Risk Assessment of Micronutrients Deficiency in Vegetarian or Vegan Children: Not So Obvious

Nutrients, Journal Year: 2023, Volume and Issue: 15(9), P. 2129 - 2129

Published: April 28, 2023

Vegetarian diets have gained in popularity worldwide and therefore an increasing number of children may be exposed to the resulting nutritional consequences. Among them, risk micronutrient shortfall is particularly concern. This narrative review aims assess discuss relevance deficiency based on available data. It mainly draws attention iron, zinc, iodine, vitamins B12 D intake. Diets that are more restrictive animal source foods, such as vegan diets, a greater likelihood deficiencies. However, actual vegetarian relatively difficult assert limitations evidence due lack well-designed studies. The vitamin must considered newborns from or macrobiotic mothers with most diet, well iodine deficiency, possibly by performing appropriate tests. A lacto-ovo-vegetarian diet exposes low if it uses very varied sufficient intake dairy products. Vegan should avoided during pregnancy childhood. There need for education nutrition guidance supplementation assessed individually.

Language: Английский

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Nutrient-heavy metal interaction and mixed heavy metal exposure in relation to cognition across lifespan: review evidence, potential mechanisms, and implications

Nutritional Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12

Published: Jan. 13, 2025

Objectives Increasing research has shown that heavy metal as a neurotoxicant affects cognitive function across the lifespan. Nutritional status may modify susceptibility to exposures, which further impacts cognition.

Language: Английский

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